Plantago major (Planten) : medicinal properties in alcoholic extraction

Plantago major (Planten, Plantain) — family Plantaginacées.

Scientific synonyms : Plantago borysthenica-W., P dregeana-D, P latifolia-S, P officinarum-C, P sinuata-Lam.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 18 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 68 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Infected wound: wound (skin and oral), injury, diabetic foot

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ghanadian M (2022)

     Excerpt The wound healing effect of Plantago major leaves has been shown in a few animal studies. For patients in the drug group, Plantago extract 10% topical gel was applied on the wound once daily concurrent with dressing and routine wound care for two weeks, while for the control group, an appropriate novel dressing was used along with routine wound care for the same duration.

   • According to Kartini K (2021)

     Excerpt major leaf extracts (PMLE), UA, & OA in hyperglycemic rats, to evaluate their in vitro diabetic wound healing activity, & to observe possible dermal irritation after topical application. Plantago major has been used empirically to improve wound healing.

   • According to Abdulghani M.A (2014)

     Excerpt Results: showed that the continuous post-treatment for 14 days with the 1000 mg/kg of PM showed potential hypoglycaemic activity in OGTT & antidiabetic activity in streptozotocin induced rat models. Methodology: adult male Sprague dually (SD) rats were used in the experiment for hypoglycaemic activity in oral glucose tolerance test (OGTT) & antidiabetic activity in streptozotocin induced rats.

   • According to Jin CB (2006)

     Excerpt The decoction of the whole Plantago major plant is normally used in the traditional treatment for diabetes. The objective of this study was to verify the hypoglycaemic property of PM aqueous leaf extract by using diabetic animal model.

   • According to Noor H (n.d.)

     Excerpt Noor H et al, Medicinal properties of Plantago major: hypoglycaemic & male fertility studies, Pertanika J of Trop Agric Sci,.

2. 2

   Normalisation of serum parameters (AST, ALT)

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to HUSSAN F (2015)

     Excerpt major leaf extracts on inflammatory reaction following acetaminophen (APAP) hepatotoxicity. At day 7, the blood and liver tissue were collected to determine plasma cytokines & tissue 11 β -HSD type 1 enzyme.

   • According to Ruffa MJ (2002)

     Excerpt Methanolic extracts from Achyrocline satureioides, Aristolochia macroura Gómez, Lithraea molleoide, Schinus molle, unlike those from Celtis spinosa Spreng, Chenopodium ambrosioides, Petiveria alliacea & Plantago major. showed cytotoxic activity against a human hepatocellular carcinoma cell line, Hep G2.

   • According to Moradi-Ozarlou M (2020)

     Excerpt major was administered through intraperitoneal route at the dose of 50 & 100 mg/kg for 14 days The liver & kidney samples were used for histopathological investigation. major is beneficial in terms of reducing the adverse effects of testicular I/R on the kidney & liver tissues & this procedure can be applied in the clinical trials,.

   • According to Turel I (2009)

     Excerpt Turel I et al, Hepatoprotective & anti-inflammatory activities of Plantago major L, Indian J of Pharmacol, 41:3, 2009.

   • According to Keshavarz A (2022)

     Excerpt : Great plantain (Plantago major is a medicinal plant that is available all around the world.

3. 3

   Cirrhosis, hepatitis, fatty liver disease

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to HUSSAN F (2015)

     Excerpt major leaf extracts on inflammatory reaction following acetaminophen (APAP) hepatotoxicity. At day 7, the blood and liver tissue were collected to determine plasma cytokines & tissue 11 β -HSD type 1 enzyme.

   • According to Ruffa MJ (2002)

     Excerpt Methanolic extracts from Achyrocline satureioides, Aristolochia macroura Gómez, Lithraea molleoide, Schinus molle, unlike those from Celtis spinosa Spreng, Chenopodium ambrosioides, Petiveria alliacea & Plantago major. showed cytotoxic activity against a human hepatocellular carcinoma cell line, Hep G2.

   • According to Moradi-Ozarlou M (2020)

     Excerpt major was administered through intraperitoneal route at the dose of 50 & 100 mg/kg for 14 days The liver & kidney samples were used for histopathological investigation. major is beneficial in terms of reducing the adverse effects of testicular I/R on the kidney & liver tissues & this procedure can be applied in the clinical trials,.

   • According to Turel I (2009)

     Excerpt Turel I et al, Hepatoprotective & anti-inflammatory activities of Plantago major L, Indian J of Pharmacol, 41:3, 2009.

   • According to Keshavarz A (2022)

     Excerpt : Great plantain (Plantago major is a medicinal plant that is available all around the world.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.