Plantago ovata (Yellow plantain) : medicinal properties in alcoholic extraction

Plantago ovata (Yellow plantain, Planten-jôn, Plantain jaune) — family Plantaginacées.

Scientific synonyms : PlaPlantago brunnea Morris, P fastigiata Morris, P gooddingii A.Nels. & Kennedy, P insularis Eastw, P minima A.Cunningham.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 66 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to USATIUC LO (2025)

     Excerpt Polycystic ovary syndrome (PCOS), a common & multifactorial endocrine disorder in reproductive-aged women, is strongly associated with insulin resistance (IR) & type 2 diabetes mellitus (T2DM), & also affects up to one in four women with type 1 diabetes mellitus (T1DM). ovata) seed ethanol extract (POEE) to modulate oxidative stress (OS), inflammatory responses, metabolic profiles, & hormonal levels in rat Streptozotocin (STZ)-induced DM & Letrozole (LET)-induced PCOS.

   • According to Sutradhar K (2022)

     Excerpt the plantation, evolvement, phytochemical, pharmaceutical and pharmacological properties of Plantago ovata have been reviewed to reconnoiter the plant’s diverse properties. It has a variety of medicinal and pharmacological effects as it is frequently employed in a variety of medications for its medicinal features such as mucilage, super-disintegrant, gelling agent & suspending agent as well as pharmacological effects such as anti-diarrheal, anti-constipation, wound curer, hypocholesterolemic and hypoglycemia.

   • According to KUMAR A (2026)

     Excerpt This review aims to provide insights into the various characteristics of psyllium husk (Plantago ovata). Psyllium husk can be used as an adjunct therapy in managing body weight, hypercholesterolemia, type 2 diabetes, & gut health.

   • According to Hannan J.M (2006)

     Excerpt Plantago ovata has been reported to reduce postprandial glucose concentrations in diabetic patients. In 28 d chronic feeding studies in type 2 diabetic rat models, the extract reduced serum atherogenic lipids & NEFA but had no effect on plasma insulin & total antioxidant status.

   • According to MORENO LA (2003)

     Excerpt Psyllium or ispaghula husk (the husk of the seeds of Plantago ovata) is a mixture of neutral & acid polysaccharides containing galacturonic acid with a ratio of soluble/insoluble fibre of 70/30. In children & adolescents from developed countries, obesity prevalence has strongly increased in the last decades & insulin resistance & impaired glucose tolerance is frequently observed.

2. 2

   Cancer; adjuvant treatment for colorectal carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Przybyszewska J (2024)

     Excerpt This article presents the evidence available in the literature on the therapeutic potential & possible mechanisms of action of psyllium in the treatment of irritable bowel syndrome & ulcerative colitis, & prevention of colorectal cancer. It has also been documented that psyllium ingestion exhibits antioxidant, immunomodulatory, antiproliferative, anticancer, & antiviral effects.

   • According to Gálvez M (2003)

     Excerpt Methanolic extracts from seven Plantago species used in traditional medicine for the treatment of cancer, were evaluated for cytotoxic activity against three human cancer cell lines recommended by the National Cancer Institute (NCI, USA). Since the flavonoids are able to strongly inhibit the proliferation of human cancer cell lines, we have identified luteolin-7-O-β-glucoside as major flavonoid present in most of the Plantago species.

   • According to Real M (2015)

     Excerpt This study was designed to determine the presence of hormone-like activities dependent on the activation of human estrogen receptor alpha (hERa) and/or androgen receptor (hAR) in methanol extracts prepared from three medicinal plants historically & currently used for therapeutic purposes: Ginkgo biloba leaves (GBL), Elettaria cardamomum seeds (ECS) & Plantago ovata seeds (POS). After a solid-liquid extraction (SLE) step, their effects on HerA function were assessed in MCF-7 breast cancer cells using the E-Screen bioassay, & their ability to induce hAR-mediated reporter gene expression was evaluated using the androgen-sensitive stable prostatic PALM cell line.

   • According to NORDGAARD L (1996)

     Excerpt NORDGAARD L et al, Colonic production of butyrate in patients with previous colonic cancer during long-term treatment with dietary fibre (Plantago ovata Seeds).

   • According to Juarranz M (2002)

     Excerpt Juarranz M et al, Physical exercise, use of Plantago ovata & aspirin, & reduced risk of colon cancer.

3. 3

   Gastric ulcer

   Plant part used: Seed. Mentioned synergistic association: Plantago major- semences.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to KHEDHER A (2022)

     Excerpt wt) significantly protected against ethanol-induced gastric ulcer in rats by decreasing the ulcer index value & preserving the integrity of the gastric mucosa. This study aimed to determine the antiulcerogenic & antioxidant activities of Psyllium (Plantago ovata Forssk) seed ethanolic extract in rats.

   • According to BAGHERI SM (2018)

     Excerpt BAGHERI SM et al, Antiulcer & hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin ulcerated rats.

   • According to KUMAR A (2026)

     Excerpt This review aims to provide insights into the various characteristics of psyllium husk (Plantago ovata). RECENT FINDINGS: The studies have highlighted the multifaceted functional properties of psyllium husk, including its high water-holding capacity, gel-forming ability, & viscosity, which contribute to its efficacy in promoting gastrointestinal health.

   • According to FERNANDEZ-Banares F (2014)

     Excerpt Plantago ovata husk therapy could be used in patients with Parkinson disease to reduce the symptoms of gastrointestinal disorders, but it is important to know whether this compound modifies levodopa pharmacokinetics.

   • According to Real M (2015)

     Excerpt This study was designed to determine the presence of hormone-like activities dependent on the activation of human estrogen receptor alpha (hERa) and/or androgen receptor (hAR) in methanol extracts prepared from three medicinal plants historically & currently used for therapeutic purposes: Ginkgo biloba leaves (GBL), Elettaria cardamomum seeds (ECS) & Plantago ovata seeds (POS). Unlike POS extracts, GBL & ECS extracts showed estrogenic (0.07 & 0.20 nM E2Eq mg (-1), respectively) & anti-estrogenic (0.01 & 0.02 μM ICI182780Eq mg (-1), respectively) activities.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.