Polyalthia longifolia (Ashoka) : medicinal properties in alcoholic extraction

Polyalthia longifolia (Ashoka, Mature tree, Arbre-à-mature) — family Annonacées.

Scientific synonyms : Uvaria longiflora-Sonnerat, Unona longiflora-(S.)-Dun.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 21 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 79 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type 1 diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Katkar KV (2010)

     Excerpt Polyalthia longifolia cv. Pharmacologic studies on the bark & leaves of this plant show effective antimicrobial activity, cytotoxic function, antiulcer activity, hypoglycemic activity, & hypotensive effect.

   • According to Nair R (2007)

     Excerpt Assessment of Polyalthia longifolia var. pendula for Hypoglycemic & Antihyperglycemic activity.

   • According to Bisht D (2024)

     Excerpt Polyalthia longifolia (Sonn.) Thwaites is a tropical ethnomedicinal plant used to treat various diseases like diabetes, hypertension a urinary disorders & possess antioxidant & anti-inflammatory properties. Aim of the study: This study aimed to investigate the phytochemical composition of 70% ethanolic leaf extract of Polyalthia longifolia (Sonn.) Thwaites (PL) & evaluates its nephroprotective effects against cisplatin-induced nephrotoxicity in Wistar rats.

   • According to Doshi GM (2016)

     Excerpt India has considered Polyalthia longifolia (PL) has one of the locally important plants. The plant has its utility in skin diseases, diabetes, hypertension & helminthiasis as well as vitiated conditions of vata & pitta.

   • According to Siva-Shanmugam AT (2013)

     Excerpt leaves and in vivo antidiabetic activity against streptozotocin-induced type 1 diabetes mellitus in rats. The effect was further highlighted by the protection of the extracts against streptozotocin-induced type 1 diabetes mellitus in rats.

2. 2

   Hepatitis, cirrhosis, fatty liver

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Christina AJM (2014)

     Excerpt This study was designed to evaluate the anticancer potential of methanolic extract of fruits of Polyalthia longifolia(MEFPL)in N-Nitrosodiethylamine (DEN) induced & phenobarbital (PB) promoted hepatocellular carcinoma (HCC) in male albino Wistar rats. To conclude, results of present study strongly support the anticancer potential of MEFPL against DEN/PB induced hepatocarcinogenesis.

   • According to Jothy SL (2012)

     Excerpt In the present study, in vitro antioxidant, free radical scavenging capacity, & hepatoprotective activity of methanol extracts from Polyalthia longifolia & Cassia spectabilis were evaluated using established in vitro models such as ferric-reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl, hydroxyl radical, nitric oxide radical scavenging, metal chelating, & antilipid peroxidation activities. longifolia leaf extract could protect the liver against paracetamol-induced oxidative damage by possibly increasing the antioxidant protection mechanism in mice.

   • According to Balamuruganvelu S (2014)

     Excerpt Med Sci, 2(3A) :908-13, 2014.A-bstract: The present study was conducted to assess the hepatoprotective activity of ethanolic leaf extract of Polyalthia longifolia against paracetamol induced liver damage in rats. Balamuruganvelu S et al, Hepatoprotective Activity of Polyalthia longifolia Leaves against Paracetamol Induced Hepatotoxicity in Rats, Scholars J of Appli.

   • According to Siva-Shanmugam AT (2013)

     Excerpt The results of this present study suggest that the ethanol & chloroform extracts of leaves of Polyalthia longifolia showed α-amylase & α-glucosidase enzymes inhibitory activity. To study the α-amylase & α-glucosidase enzymes inhibitory activity in vitro of ethanol (PLEE) & chloroform (PLCE) extracts of Polyalthia longifolia (Sonner.) Thaw.

   • According to Tanna A (2009)

     Excerpt Tanna A et al, Assessment of anti-inflammatory & hepatoprotective potency of Polyalthia longifolia var.

3. 3

   Bacterial infection: Escherichia coli, Bacillus subtilis, Salmonella typhi, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella sp

   Plant part used: Bark (stem).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Jain T (2011)

     Excerpt Escherichia coli (Gram-ve), Bacillus subtilis (Gram+ve), Salmonella typhi (Gram-ve), Proteus mirabilis (Gram-ve), Pseudomonas aeruginosa (Gram-ve) and Klebsiella sp. The stem bark of Polyalthia longifolia were dried, powdered and extracted with a series of non-polar to polar solvent i.e.

   • According to Ghosh A (2008)

     Excerpt Staphylococcus aureus MTCC 2940, Bacillus subtilis MTCC 441, Escherichia coli MTCC 739, Klebsiella pneumoniae MTCC 530, Proteus vulgaris MTCC 426 & Enterobacter aerogenes MTCC 111. The present study evaluated the antibacterial potentiality of hot aqueous & methanol solvent extract of mature leaves of Polyalthia longifolia against six reference bacteria viz.

   • According to Uzama D (2011)

     Excerpt The extract of P Longifolia leaves was very active against Bacillus subtilis & Staphylococcus aureus at 25mg/ml but has no activity with Klebsiella pneumonia & Escherichia coli at the same concentration. The study indicated that the extract of the leaves of Lemon grass was very active against Klebsiella pneumonia & Staphylococcus aureus at 25mg/ml but has no activity with Bacillus subtilis & Escherichia coli at the same concentration.

   • According to Manasa M (2014)

     Excerpt Antibacterial activity of leaf & pericarp extracts was determined against Staphylococcus aureus, Salmonella typhi & Klebsiella pneumoniae by Agar well diffusion assay. The present study was conducted with an aim of determining antimicrobial activity of leaf & pericarp (ripe and unripe) extracts of Polyalthia longifolia (Annonaceae).

   • According to Gbedema SY (2015)

     Excerpt In this study the ethanolic extract of Polyalthia longifolia (Sonn) Thw. longifolia compounds therein strongly suggests its usefulness as an antimalarial agent & supports its inclusion or exploitation in formulations of herbal remedies for malaria in Ghana.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.