Polyscias fructicosa : medicinal properties in alcoholic extraction

Polyscias fructicosa (Gwo Womaren, Gros romarin) — family Araliacées.

Scientific synonyms : Panax fruticosus L., Nothopanax fruticosus (L.) Miq., Tieghemopanax fruticosus (L.) R.Vig., Aralia fruticosa (L.) L.H.Bailey.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 9 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 66 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Osteoarthritis, rheumatism, oedema, arthritis

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rarison R.H.G (2023)

     Excerpt Overall, these findings provide valuable insights into the antioxidant & anti-inflammatory properties of lipophilic extracts from PFL, which can be used as a fundamental basis for developing nutraceuticals & functional foods,. This study, integrating network pharmacology analysis with in silico & in vitro approaches, aimed to elucidate the antioxidant & anti-inflammatory capacities of lipophilic extracts from PFL.

   • According to Bernard BM (1998)

     Excerpt The n-butanol extract of the leaves Polyscias fruticosa (L) Harms (Araliaceae) was tested for its anti-inflammatory activity plethysmometrically in egg white induced paw oedema in rats, antipyretic activity & analgesic activity by writhing method phenylbutazone, paracetamol & aspirin were used as positive controls for anti-inflammatory, antipyretic & analgesic activity screening studies receptivity.

   • According to Tran PT (2019)

     Excerpt Polyscias fruticosa has been used as traditional medicine for the treatment of ischemia & inflammation & also eaten as a salad. Purpose: This study aimed to investigate the effect of ethanol extract of PF on RANKL-induced osteoclastogenesis in vitro & LPS-induced bone loss in mouse, & evaluate anti-osteo-clastogenic activities of its major constituents.

   • According to Nguyen NQ (2020)

     Excerpt Polyscias fruticosa is an herbal plant having a myriad of medicinal purposes, especially in antioxidant activities, anti-inflammatory & antipyretic.

   • According to Koffuor GA (2014)

     Excerpt Aim: This study evaluated the anti-inflammatory property of an ethanolic leaf extract of PF & safety for use in ovalbumin-induced asthma. PFE showed no significant toxic effect at lower doses (NOAEL: < 1000 mg/kg) Conclusion: The ETOH leaf extract of PF reduces white blood cell count & its differentials in blood, hence its anti-inflammatory effect; a useful property in the treatment of asthma.

2. 2

   Bronchial asthma: paroxysmal dyspnoea

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bernard BM (1998)

     Excerpt The n-butanol extract of the leaves Polyscias fruticosa (L) Harms (Araliaceae) was tested for its anti-inflammatory activity plethysmometrically in egg white induced paw oedema in rats, antipyretic activity & analgesic activity by writhing method phenylbutazone, paracetamol & aspirin were used as positive controls for anti-inflammatory, antipyretic & analgesic activity screening studies receptivity.

   • According to Rarison R.H.G (2023)

     Excerpt Overall, these findings provide valuable insights into the antioxidant & anti-inflammatory properties of lipophilic extracts from PFL, which can be used as a fundamental basis for developing nutraceuticals & functional foods,. This study, integrating network pharmacology analysis with in silico & in vitro approaches, aimed to elucidate the antioxidant & anti-inflammatory capacities of lipophilic extracts from PFL.

   • According to Koffuor AG. (2016)

     Excerpt Conclusion: PFE has anti-asthmatic, antihistaminic, & mast cell stabilization effect making it useful in traditional asthma management.

   • According to Koffuor GA (2014)

     Excerpt Aim: This study evaluated the anti-inflammatory property of an ethanolic leaf extract of PF & safety for use in ovalbumin-induced asthma. PFE showed no significant toxic effect at lower doses (NOAEL: < 1000 mg/kg) Conclusion: The ETOH leaf extract of PF reduces white blood cell count & its differentials in blood, hence its anti-inflammatory effect; a useful property in the treatment of asthma.

   • According to Titova, M.V (2023)

     Excerpt Polyscias fruticosa (L.) Harms, or Ming aralia, is a medicinal plant of the Araliaceae family, which is highly valued for its antitoxic, anti-inflammatory, analgesic, antibacterial, anti-asthmatic, adaptogenic, & other properties.

3. 3

   Bacterial infection: Bacillus subtilis, Escherichia coli, Staphylococcus aureus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ashmawy (2020)

     Excerpt Phytochemical investigations of Polyscias species revealed the isolation of about 97 chemical compounds from various chemical classes, including saponins as major constituents; Biological studies demonstrated that Polyscias extracts & their bioactive compounds possess antibacterial, antifungal, cytotoxic, immuno-stimulant, wound-healing & anti-asthmatic activities;. Studies on species of this genus have provided essential data regarding the chemical composition & pharmacological activities of Polyscias extracts & isolated secondary metabolites.

   • According to Bensita MB (1999)

     Excerpt Bensita MB et al, Studies on the adaptogenic & antibacterial properties of Polyscias fructicosa (L.) Harms.

   • According to Mawea F (2062)

     Excerpt Mawea F et al, Review: Antibacterial Activity of Polyscias fruticosa & Molecular Mechanism of Active Compounds.

   • According to Titova, M.V (2023)

     Excerpt In antibacterial tests, the minimum inhibitory concentrations (MICs) of cell biomass extracts against the most common pathogens Staphylococcus aureus, Methicillin-Resistant strain MRSA, Pseudomonas aeruginosa, & Escherichia coli varied within 250-2000 µg mL-1 which was higher compared to extracts of greenhouse plant leaves (MIC = 4000 µg mL-1). Polyscias fruticosa (L.) Harms, or Ming aralia, is a medicinal plant of the Araliaceae family, which is highly valued for its antitoxic, anti-inflammatory, analgesic, antibacterial, anti-asthmatic, adaptogenic, & other properties.

   • According to Slivinska AA (2025)

     Excerpt These constituents exhibit antioxidant, anti-inflammatory, antimicrobial, antidiabetic, anticancer, & neuro-protective activities, with selected saponins (e.g., chikusetsusaponin IVa, PF saponin [PFS], zingibroside R1) showing confirmed molecular mechanisms of action. Polyscias fruticosa (L.) Harms, a Southeast Asian medicinal plant of the Araliaceae family, has gained increasing attention due to its rich phytochemical profile & potential pharmacological applications.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.