Pometia pinnata (Kava) : medicinal properties in alcoholic extraction

Pometia pinnata (Kava, Pacific lychee, Litchi du pacifique) — family Sapindacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 53 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hypertension: kidney damage in people with type 2 diabetes

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Tandi J (2022)

     Excerpt Diabetes Mellitus is a metabolic disease characterized by high blood glucose levels which is commonly called hyperglycemia due to lack of insulin secretion. One of the matoa plants (Pometia pinnata) that has been used as a traditional medicine is PP leaves which are efficacious as diabetes mellitus.

   • According to Prihanti GS (2020)

     Excerpt Diabetes mellitus is characterized by a hyperglycemia, characterized by increased blood sugar level & glycosylated hemoglobin (HbA1c). PP stem bark extract has been shown to have antidiabetic effects that affect blood sugar levels, HbA1c, MDA, and the mean of Langerhans Island allistan-induced male Wistar rats (Rattus norvegicus).

   • According to Utoro PAE (2022)

     Excerpt Pometia pinnata merupakan tumbuhan tropis yang berasal dari famili Sapindaceae tersebar luas di daerah Indonesia yang dimanfaatkan masyarakat sebagai obat tradisional yang dikenal sebagai daun matoa. Beberapa penelitian melaporkan bahwa daun matoa memiliki banyak manfaat, antara lain sebagai penurun tekanan darah, membantu mengobati diabetes, penyakit perut (diare dan disentri), penyakit ginekologi, & saat ini daun PP dikembangkan sebagai suplemen atau fortifikasi pada susu.

   • According to Elisa N (2020)

     Excerpt The leaves of matoa, which have another name, Pometia pinnata, are one of the plants used as traditional medicine for the treatment of hypertension. Hypertension is a problem of cardiovascular disease that occurs in many people.

   • According to Adrian Syahputra (2021)

     Excerpt Pometia pinnata (PE) or commonly referred to as matoa is a typical plant, especially Papua, Indonesia. But using cisplatin can cause very serious nephrotoxicity & acute kidney injury (AKI).

2. 2

   Cancer: adjuvant treatment for colorectal and liver carcinoma

   Plant part used: Fruit peel.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Suzuki T (2021)

     Excerpt This study investigated the anti-obesity effects of matoa (Pometia pinnata) & salak (Salacca zalacca) fruit peel. The anti-obesity effect of PP was partly explained by the inhibitory effect of the PP peel extract on fatty acid-induced secretion of ApoB-48 protein, a marker of intestinal chylomicrons, in differentiated Caco-2 cell monolayers.

   • According to Adrian A (2021)

     Excerpt AIM: The aim of this study is to determine the hepatoprotective activity of extract ethanol Pometia pinnata on rats induced Cisplatin. CONCLUSION: In summary, extract ethanol of PP has hepatoprotective effect by reducing the level of AST, ALT, total protein, & LDH levels.

   • According to Sihotang y (2017)

     Excerpt Neutralizing reactive oxygen species enhancing the activity of original natural hepatic-antioxidant enzymes may be the main mechanisms of EEML against paracetamol-induced injury. These results indicate that the hepatoprotective action of EEML is likely related to its potent antioxidative activity.

   • According to Ginola-Barus HD (2018)

     Excerpt The results of the average levels of total serum bilirubin of normal control group, positive, negative, extract dose, 125,250, & 500 mg/kgBW respectively was0 ,67 +-0,14 mg/dl, 0,68 +- 0,11 mg/dL, 1,66 +-0,26 mg/dL, 1,34 +- 0,06mg/1L, 1,15 +- 0,06 mg/dL, & 0, 78 +- 0, 06 mg/dL. Group 1 as normal group given only 1% CMC-Na suspension, Group II as negative control given Paracetamol 2 kg/BW, group 8III as a positive control given N-Acetylcysteine, & group IV, V, VI, as a group test with a f)-difference a dose at 125,250, & 55 kgBW.

   • According to Parlin D.A (2022)

     Excerpt The cytotoxicity test using the BSLT method gave an LC50 value of 356.7795 μg/ml so that the ethanol extract of PP leaves can be concluded to be cytotoxic & has potential as an anticancer drug. This study aimed to determine the potency of ethanolic extract of PP leaves as an anticancer by determining the LC50 & secondary metabolites in PP leaves.

3. 3

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Tandi J (2022)

     Excerpt Diabetes Mellitus is a metabolic disease characterized by high blood glucose levels which is commonly called hyperglycemia due to lack of insulin secretion. One of the matoa plants (Pometia pinnata) that has been used as a traditional medicine is PP leaves which are efficacious as diabetes mellitus.

   • According to Prihanti GS (2020)

     Excerpt Diabetes mellitus is characterized by a hyperglycemia, characterized by increased blood sugar level & glycosylated hemoglobin (HbA1c). To determine the antidiabetic effect of PP stem bark extract on alloxan-induced Wistar rats.

   • According to Utoro PAE (2022)

     Excerpt Pometia pinnata merupakan tumbuhan tropis yang berasal dari famili Sapindaceae tersebar luas di daerah Indonesia yang dimanfaatkan masyarakat sebagai obat tradisional yang dikenal sebagai daun matoa. Beberapa penelitian melaporkan bahwa daun matoa memiliki banyak manfaat, antara lain sebagai penurun tekanan darah, membantu mengobati diabetes, penyakit perut (diare dan disentri), penyakit ginekologi, & saat ini daun PP dikembangkan sebagai suplemen atau fortifikasi pada susu.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.