Sapindus saponaria (Savonnèt) : medicinal properties in alcoholic extraction

Sapindus saponaria (Savonnèt, Savonnette) — family Sapindacées.

Scientific synonyms : Sapindus forsythii DC., S inaequalis-DC, S microcarpus-J.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 26 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for prostate cancer

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to CARDOSO SC (2009)

     Excerpt Ethanolic extract from Sapindus saponaria showed Cytotoxicity around 80% on initial experiments, & therefore were Selected for a dose-response analysis, further demonstrating a significant and reproductible dose-dependent effect with IC50 61.63 ug/mL after 48h. DISCUSSION: One ethanolic extract showed a significant dose-dependent Antiproliferative activity.

   • According to Meyer AAL (2001)

     Excerpt The obtained fractions, hydroiised or not, were active against U1vüro Ehrlich Ascitic Tumour (EAT).

   • According to Araujo dos Santos BT (2013)

     Excerpt Results: The species Allamanda blanchetti, Erythroxylum subrotundum, Genipa Americana & Sapindus saponaria demonstrated a proliferation inhibitory activity ≥ 50% on cytotoxicity assays & showed an adequate reproducibility on dose response assays & had their IC50 calculated.

   • According to Da Silva ML (2012)

     Excerpt Sapindus saponaria bark, root, & fruits are used as sedatives & to treat gastric ulcer & also demonstrate diuretic & expectorant effects. Conclusion: SS extracts & fractions presented anti-ophidian activity & could be used as an adjuvant to serum therapy or for its supplementation, & in addition, as a rich source of potential inhibitors of enzymes involved in several pathophysiological human & animal diseases.

2. 2

   Pheochromocytoma

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to CARDOSO SC (2009)

     Excerpt Ethanolic extract from Sapindus saponaria showed Cytotoxicity around 80% on initial experiments, & therefore were Selected for a dose-response analysis, further demonstrating a significant and reproductible dose-dependent effect with IC50 61.63 ug/mL after 48h. DISCUSSION: One ethanolic extract showed a significant dose-dependent Antiproliferative activity.

   • According to Araujo dos Santos BT (2013)

     Excerpt Results: The species Allamanda blanchetti, Erythroxylum subrotundum, Genipa Americana & Sapindus saponaria demonstrated a proliferation inhibitory activity ≥ 50% on cytotoxicity assays & showed an adequate reproducibility on dose response assays & had their IC50 calculated. Conclusion: On this biological trial of Cerrado Biome, 5 of 18 plant extracts demonstrated the ability to control pheochromocytoma cell line proliferation.

   • According to Meyer AAL (2001)

     Excerpt The obtained fractions, hydroiised or not, were active against U1vüro Ehrlich Ascitic Tumour (EAT).

3. 3

   Dental infection: Staphylococcus aureus, Streptococcus mutans, Streptococcus salivarius, Streptococcus sanguinis & Lactobacillus acidophilus

   Plant part used: seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Niloufer S (2021)

     Excerpt The results of anti-bacterial activity were found that ethanolic extract of SS was most effective against all tested bacterial pathogens (Staphylococcus aureus, Streptococcus mutans, Streptococcus salivarius, Streptococcus sanguinis & Lactobacillus acidophilus). In the present study, seed kernel ethanolic extract of Sapindus saponaria was analysed for its phytochemical, anti-oxidant capacity & anti-bacterial activity on Common Dental Pathogens.

   • According to Damke E (2013)

     Excerpt The spermicidal & anti-Trichomonas activity of SS & its effect on Lactobacillus acidophilus were evaluated. Sapindus saponaria is used traditionally for curing ulcers, external wounds & inflammations.

   • According to Thotat P (n.d.)

     Excerpt The petroleum ether, ethanol & chloroform extracts of Sapindus saponaria leaf having extractive value 10 gm, 7.9 gm & 6.4 gm (Table 1) on phytochemical screening showed the presence of alkaloids, saponins, steroids, flavonoids, glycosides & phenols as chemical constituents. In vitro antibacterial studies of these leaf extracts were carried out on four medically important bacterial strains, including Streptococcus faecalis, Streptococcus aureus, Bacillus subtilis and Bacillus peritolis which were procured from the Microbial Type Culture and Collection, Chandigarh, India, using agar disc diffusion method.

   • According to Damke E (2011)

     Excerpt Study of in vivo antifungal activity of the hydroalcoholic extract (HE) & n-BuOH extract (BUTE) of Sapindus saponaria against azole-susceptible & -resistant human vaginal Candida spp. The rats were treated intravaginally with 0.1 mL of HE or BUTE at concentrations of 1%, 2.5% & 5%; 100 μg/mL of FLU (treatment positive control); or distilled water (negative control) at 1, 24, & 48 h after induction of the infection, & the progress of VVC was monitored by culturing & scanning electron microscopy (SEM).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.