Solanum torvum (Magwôt) : medicinal properties in alcoholic extraction

Solanum torvum (Magwôt, grenn-Magwôt, Milonjenn-djab, Grenn-dendon, Margote, Seed-of-margote, Devil’s seed, Turkey seed, Graine-à-margote, Graine-à-diable, graine-à-dindon) — family Solanacées.

Scientific synonyms : Solanum ficifolium-Ortega, S. daturifolium-Dunal, S. maccai-Rich, S. Stramonifolium, -Roxb non-Jacq, S. pseudosaponacerum-Blume, S. Roquesanum-Desc, S. inclusum-Stahl, S. mannii-CH. Wright.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 19 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 101 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Diabetes-related obesity

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to VASUKI. R (2011)

     Excerpt The present study dealt with the investigation of Antiobesity & Anti-diabetic effects of ethanolic extract of leaves of Solanum torvum (STE) using obese, diabetic-induced albino rats.

   • According to Sorna Kumar RSA (2016)

     Excerpt In-vitro test tube based α–Amylase inhibition activity to determined anti-diabetic activity of samples showed a maximum of 17.4% at pH 3 for water extract of fruit of S torvum. Water extract of samples were found to be safe for hemocytes wherein methanolic extracts showed good anti-oxidant, anti-diabetic & anti-microbial activity.

   • According to CHOUIDHURY AA (2073)

     Excerpt This study focused on Solanum torvum (STV), a medicinal plant, to identify potential anti-diabetic compounds using molecular docking & molecular dynamics simulations. In conclusion, our study suggests that chlorogenin & rutin derived from STV may be effective natural therapeutic agents for diabetes management because of their strong binding affinities for the α-amylase & α-glucosidase enzymes,.

   • According to Mohan M (2020)

     Excerpt torvum on diabetic neuropathy in alloxan-induced diabetic rats. Diabetes was induced in Wistar rats by using a single intraperitoneal injection of alloxan monohydrate (150 mg/kg; i.p.).

   • According to Mohan M (2009)

     Excerpt Aim of the study: The present study was aimed to determine the effect of ethanolic extract of Solanum torvum (100 and 300 mg/kg; p.o. Solanum torvum (Solanaceae) is a plant used in Cameroon ethnomedicine for the treatment of hypertension.

2. 2

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sorna Kumar RSA (2016)

     Excerpt In-vitro test tube based α–Amylase inhibition activity to determined anti-diabetic activity of samples showed a maximum of 17.4% at pH 3 for water extract of fruit of S torvum. For hydroxyl free radical scavenging activity, Solanum torvum inhibited hydroxyl free radical by 33.72% in its water extract of fruit.

   • According to Satyarayana N (2022)

     Excerpt Solanum torvum Swartz, a medicinal plant belonging to the family Solanaceae, is an important medicinal plant widely distributed throughout the world & used as medicine to treat diabetes, hypertension, tooth decay, & reproductive problems in traditional systems of medicine around the world including Malaysia. torvum fruit in streptozotocin-induced diabetic Sprague–Dawley rats.

   • According to Gandhi GR (2011)

     Excerpt The effects of oral administration of methyl caffeate (10, 20 & 40mg/kg) for 28days on body weight, fasting blood glucose, plasma insulin, hemoglobin, glycated hemoglobin, total protein, hepatic glycogen & carbohydrate metabolism enzymes in streptozotocin induced diabetic rats were investigated. In streptozotocin induced diabetic rats, methyl caffeate produced significant reduction in blood glucose & increased body weight.

   • According to Gopalsamy R G (2011)

     Excerpt Gopalsamy R G et al, Antihyperglycemic activity & antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz fruit in streptozotocin induced diabetic rats.

   • According to Mohan M (2020)

     Excerpt torvum on diabetic neuropathy in alloxan-induced diabetic rats. Diabetes was induced in Wistar rats by using a single intraperitoneal injection of alloxan monohydrate (150 mg/kg; i.p.).

3. 3

   Abnormal serum levels: LDL, AST, ALP, low HDL

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to KUETE V (2005)

     Excerpt The results of the subacute toxicity study showed significant variation in the body weight, but no modification (P >0.05) of blood & liver parameters compared to the control group. Acute & subacute toxicity of the hydroethanolic extract of the ripe fruit of Solanum torvum Sw.

   • According to Manikhandaselvi. S (2012)

     Excerpt S et al, Modulation of lysosomal enzymes activity by Carica papaya Linn & Solanum torvum Linn in carbon tetrachloride vapour induced liver damage in rats, J of Chem & Pharmaceut Res, 2012, 4(2):1235-8.

   • According to Kusirisin, W (2009)

     Excerpt Kusirisin, W et al, Effect of Polyphenolic Compounds from Solanum torvum on Plasma Lipid Peroxidation, Superoxide anion & Cytochrome P450 2E1 in Human Liver Microsomes, Med Chem, 5:583-588(6): 2009,.

   • According to Muthezhilan SW (2012)

     Excerpt Muthezhilan SW et al, Fatty Acid Composition and Antimicrobial Activity of Solanum torvum Jl OF MODERN BIOTECHNOL, 1(2):75–78, 2012,.

   • According to Satyarayana N (2022)

     Excerpt torvum fruit on body weight, blood glucose, lipid profile, liver enzymes, histopathology of pancreas, & gene expression of glucose transporter 2 (slc2a2), & phosphoenolpyruvate carboxykinase (PCK1) was determined by RT-PCR. Conclusion: Ethanolic extract of ST fruits showed hypoglycemic, hypolipidemic, & hepatoprotective activity in streptozocin-induced diabetic rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.