Spermacoce verticillata (Makônnèt) : medicinal properties in alcoholic extraction

Spermacoce verticillata (Makônnèt, Zèb-a-Kônèt, Balié blan, Cornette, herbe-à-cornette, Balai blan.) — family Rubiacées.

Scientific synonyms : Borreria verticillata-(L)-MEY, B podocephala-DC.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 40 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: Staphylococcus aureus, Neisseria gonorrhoeae, Streptococcus pneumoniae, Mycobacterium fortuitum, Gardnerella vaginalis

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Baldé AM (2015)

     Excerpt Extracts of the plant species were found to exhibit in vitro moderate to weak antimicrobial activity against Staphylococcus aureus, Streptococcus viridians, Streptococcus pneumoniae, Neisseria gonorrhoeae, Mycobacterium fortuitum, Gardnerella vaginalis, human immunodeficiency virus (HIV), Candida albicans & Candida tropicalis. In the Guinean traditional medicine, Borreria verticillata is widely used in the treatment of skin diseases.

   • According to Onwuliri EA (2016)

     Excerpt The wounds were first infected with the Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa & Staphylococcus aureus respectively & dressed daily with the ointment. This study investigated the anti-microbial & wound healing properties of acetone leaf extract & ointment formulation of Spermacoce verticillata Linn (Family Rubiaceae).

   • According to Maynart G (1980)

     Excerpt The minimal inhibitory concentration is lower than 50 micrograms/ml for Gram positive cocci, (specially Staphylococcus aureus) & then 6 micrograms/ml for Vibrio cholerae & upper than 200 micrograms/ml for several Gram-negative rod-bacteria (Enterobacteria & Pseudomonas). These preliminary results underline the interest in the research about the antimicrobial agents from plant origin, in particular concerning naturally or chemically modified alkaloids.

   • According to AKINJOGUNIA OJ (2018)

     Excerpt AKINJOGUNIA OJ et al, ANTIBACTERIAL EFFICACY OF AQUEOUS LEAF EXTRACTS OF Cymbopogon citratus (POACEAE) & Borreria verticillata (RUBIACEAE) ON BIOFILM PRODUCING UROPATHOGENIC BACTERIAL ISOLATES, Research-Gate, 2018-.

   • According to Aremu SO (2025)

     Excerpt This study revealed that the root extract of BV plant has an antimicrobial effect against multidrug-resistant bacteria & also antifungal potential. This study aimed to identify the active ingredients in Borreria verticillata root extract for the synthesis of new antimicrobial drugs.

2. 2

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chaurasia S (2022)

     Excerpt Studies have showed that extracts from Borreria & Spermacoce species in addition to their remoted compounds own numerous organic sports, such as anti- inflammatory, antitumor, antimicrobial, larvicidal, antioxidant, gastrointestinal, anti-ulcer, & hepatoprotective, with alkaloids & iridoids because the important energetic principles. Based on its end result morphology they may be taken into consideration via way of means of many authors to be awesome genera & maximum others, however, choose to integrate the 2 taxa below the everyday call Spermacoce.

   • According to Abdullahi-Gero HS (n.d.)

     Excerpt Carrageenan & formalin induced rat paw oedema were used to investigate anti-inflammatory effects. The ethanol leaf extract of BV (EEBV) was investigated for possible analgesic & anti-inflammatory effects in mice & rats.

   • According to LIMA LC (2018)

     Excerpt The chemotaxis inhibitory activity of both extracts & the anti-edematogenic & antinociceptive activities of SVL are characteristic effects of anti-inflammatory drugs, & these results highlight the therapeutic potential of SS against inflammatory diseases. To the best of our knowledge, this is the first report for the anti-inflammatory & antinociceptive activities for S.

   • According to Silva RHM (2017)

     Excerpt known Vassourinha has antibacterial, antimalarial, hepatoprotective, antioxidative, analgesic, & anti-inflammatory, however, its antinociceptive action requires further studies. The antinociceptive effect of BV might be predominantly attributed to peripheral actions, including the participation of anti-inflammatory components.

   • According to Conserva LM (2012)

     Excerpt Studies have confirmed that extracts from Borreria & Spermacoce species as well as their isolated compounds possess diverse biological activities, including anti-inflammatory, antitumor, antimicrobial, larvicidal, antioxidant, gastrointestinal, anti-ulcer, & hepatoprotective, with alkaloids & iridoids as the major active principles. Some of these uses include the treatment of malaria, diarrheal and other digestive problems, skin diseases, fever, hemorrhage, urinary & respiratory infections, headache, inflammation of eye, & gums.

3. 3

   Fungal infection: Candida albicans, C. tropicalis

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Aremu SO (2025)

     Excerpt This study revealed that the root extract of BV plant has an antimicrobial effect against multidrug-resistant bacteria & also antifungal potential. This study aimed to identify the active ingredients in Borreria verticillata root extract for the synthesis of new antimicrobial drugs.

   • According to Ogunwande IA (2010)

     Excerpt In addition, the volatile oils displayed promising in-vitro antimicrobial activity against the tested micro-organisms, (MIC 12.5-22.3 μg/mL), while only the oil of PB displayed in-vitro cytotoxicity to MCF-7 (human breast tumor) & MDA-MB-468 (human breast tumor) cells. verticillata had an abundance of phytol (56.3%) & 1, 8-cineole (20.4%), with sizeable proportions of α-pinene (7.1%) & p-cymene (4.0%).

   • According to Onwuliri EA (2016)

     Excerpt This study investigated the anti-microbial & wound healing properties of acetone leaf extract & ointment formulation of Spermacoce verticillata Linn (Family Rubiaceae). Fraction B had a better antimicrobial property than fraction A & this was then formulated into ointments of 0.1, 0.2, 1, 2 & 5% w/w concentrations & used for assessing wound healing on wounds inflicted on albino rats.

   • According to Maynart G (1980)

     Excerpt These preliminary results underline the interest in the research about the antimicrobial agents from plant origin, in particular concerning naturally or chemically modified alkaloids. Borreria verticillata, a very common tropical plant, is used in traditional pharmacopeia to recover cutaneous infections.

   • According to Chaurasia S (2022)

     Excerpt Studies have showed that extracts from Borreria & Spermacoce species in addition to their remoted compounds own numerous organic sports, such as anti- inflammatory, antitumor, antimicrobial, larvicidal, antioxidant, gastrointestinal, anti-ulcer, & hepatoprotective, with alkaloids & iridoids because the important energetic principles. Based on its end result morphology they may be taken into consideration via way of means of many authors to be awesome genera & maximum others, however, choose to integrate the 2 taxa below the everyday call Spermacoce.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.