Tanacetum parthenium (Tanézi) : medicinal properties in alcoholic extraction

Tanacetum parthenium (Tanézi, Gran-Kamomiy, Tanaisie, Great chamomile, Grande camomille) — family Asteracées.

Scientific synonyms : Aphanostephus pinulensis-J.M.Coult, Matricaria parthenim-L, Chamaelum parthenium-(L)-E.H.L.K., Chrysanthemum parthenium-(L)-Benth, Leucanthemum parthenium-(L)-G. & G., Pontia matricaria-Buibani, Pyrethrum sericeum var. divaricatum-(Sosn)-Sosn, Tanacetum grossheimii-(Sosn)-Muradyan..

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 72 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for cervical carcinoma, colorectal cancer, melanoma, leukaemia and medulloblastoma

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Parada-Turska J (2007)

     Excerpt In this study, we determined the effect of parthenolide on proliferation of three human cancer cell lines: human lung Carcinoma (A549), human medulloblastoma (TE671), human colon adenocarcinoma (HT-29) & human umbilical vein endothelial cells (HUVEC) in vitro. Parthenolide is a major sesquiterpene lactone derived from feverfew (Tanacetum parthenium) with known anti-inflammatory activity.

   • According to Won YK (2005)

     Excerpt We have previously reported that PN possesses strong anticancer activity in ultraviolet B (UVB)-induced skin cancer in SKH-1 hair less mice. Parthenolide (PN) is the principal sesquiterpene lactone in feverfew (Tanacetum parthenium) with proven anti-inflammatory properties.

   • According to Mathema VB (2012)

     Excerpt Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum parthenium), exhibits exceptional anticancer & anti-inflammatory properties, making it a prominent candidate for further studies & drug development. The unique ability of this compound to not harm normal cells but at the same time induce sensitization to extrinsic as well as intrinsic apoptosis signaling in cancer cells provides an important, novel therapeutic strategy for treatment of cancer & inflammation-related disorders.

   • According to Kashkooe A (2024)

     Excerpt the use of Tanacetum parthenium (L.) Sch.Bip., commonly known as feverfew, extends across various medical conditions, notably those associated with pain & inflammation. Significantly, the anti-inflammatory properties of TP have been primarily attributed to its capacity to inhibit nuclear factor-kappa B (NF-κB), resulting in a reduction in pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-α).

   • According to Zunino SJ (2007)

     Excerpt We investigated whether parthenolide, the principal bioactive component of the herb feverfew (Tanacetum parthenium) induced apoptosis in pre-B acute lymphoblastic leukemia (ALL) lines, including cells carrying the t(4;11)(q21;q23) chromosomal translocation.

2. 2

   Hyperalgesia: allodynia, neuropathic pain, sciatica

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Safakhah HA (2017)

     Excerpt The aim of this study was to evaluate the effect of Tanacetum parthenium extract on chronic constriction injury (CCI)-induced neuropathic pain. Mechanical allodynia & thermal hyperalgesia were assessed using Von Frey hairs & plantar test device, respectively.

   • According to Parvi N (2012)

     Excerpt Tanacetum parthenium has been introduced as an analgesic agent in traditional medicine and is widely used to relieve neuropathic pain and headache. Objective: The aim of this study was to investigate the analgesic effect of Tanacetum Parthenium ethanolic extract on acute pain.

   • According to Kashkooe A (2024)

     Excerpt the use of Tanacetum parthenium (L.) Sch.Bip., commonly known as feverfew, extends across various medical conditions, notably those associated with pain & inflammation. This study further delves into the neuroprotective potential of TP, specifically in the management of conditions such as migraine headaches, epilepsy, & neuropathic pain through various mechanisms.

   • According to Asgari A (2013)

     Excerpt Because of the few studies conducted on the mechanism of Tanacetum Parthenium (TP), this study has been conducted to determine the effects of TP on pain relief and its action mechanism. In order to study the pain relief effect of this herb, two groups were also received naloxon (0.5 mg/kg) and naloxon together with the 40 mg/kg of the extract.

   • According to Studzinska E (2013)

     Excerpt In folk medicine, infusions from the leaves of Tanacetum parthenium were used in rheumatism, fever, & in migraine, menstrual pain, toothaches also digestive troubles, cough, or parasitic diseases.

3. 3

   Pain, hyperalgesia

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Safakhah HA (2017)

     Excerpt The aim of this study was to evaluate the effect of Tanacetum parthenium extract on chronic constriction injury (CCI)-induced neuropathic pain. Mechanical allodynia & thermal hyperalgesia were assessed using Von Frey hairs & plantar test device, respectively.

   • According to Parvi N (2012)

     Excerpt Objective: The aim of this study was to investigate the analgesic effect of Tanacetum Parthenium ethanolic extract on acute pain. Tanacetum parthenium has been introduced as an analgesic agent in traditional medicine and is widely used to relieve neuropathic pain and headache.

   • According to Asgari A (2013)

     Excerpt Because of the few studies conducted on the mechanism of Tanacetum Parthenium (TP), this study has been conducted to determine the effects of TP on pain relief and its action mechanism. In order to study the pain relief effect of this herb, two groups were also received naloxon (0.5 mg/kg) and naloxon together with the 40 mg/kg of the extract.

   • According to Studzinska E (2013)

     Excerpt In folk medicine, infusions from the leaves of Tanacetum parthenium were used in rheumatism, fever, & in migraine, menstrual pain, toothaches also digestive troubles, cough, or parasitic diseases.

   • According to Kashkooe A (2024)

     Excerpt the use of Tanacetum parthenium (L.) Sch.Bip., commonly known as feverfew, extends across various medical conditions, notably those associated with pain & inflammation. This study further delves into the neuroprotective potential of TP, specifically in the management of conditions such as migraine headaches, epilepsy, & neuropathic pain through various mechanisms.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.