Terminalia catappa (Zanmand-péyi) : medicinal properties in alcoholic extraction

Terminalia catappa (Zanmand-péyi, Local almond tree, Amandier du pays) — family Combrétacées.

Scientific synonyms : Buceras catappa –(L)-Hitch.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 26 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 112 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of colorectal, ascites, breast, lung and uterine carcinomas and melanoma; chemoprevention of metastatic oral, liver, lung and uterine carcinomas; sickle cell crisis; pain; hyperalgesia

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Yeh CB (2012)

     Excerpt Previous studies have identified that T catappa leaf extracts (TCE) exert hepatoprotective, antioxidative, antiinflammatory, anticancer, & antimetastatic activities. In conclusion, TCE inhibits MMP-9 expression & HCC cell metastasis & thus, has potential use as a chemopreventive agent.

   • According to Zuhrotun A (2010)

     Excerpt The survival rate of malignant tumors, & especially hepatocellular carcinoma (HCC), has not improved primarily because of uncontrolled metastasis. In our previous studies, we have reported that Terminalia catappa leaf extract (TCE) exerts antimetastasis effects on HCC cells.

   • According to Singh M (2023)

     Excerpt It is able to show antimicrobial, anti-inflammatory, antidiabetic, antioxidant, hepatoprotective, & anticancer activities. Terminalia catappa is a big spreading tree in strong winds.

   • According to Yeh CB (2014)

     Excerpt In our previous studies, we have reported that Terminalia catappa leaf extract (TCE) exerts antimetastasis effects on HCC cells.

   • According to Batubo P (2018)

     Excerpt Based on the results, it can be concluded that there were no hepatotoxicity effects of hydroalcoholic T catappa kernel extract on Wister rats in 42 days experimental period & therefore it can be said to have a wide margin of safety for use & consumption. Terminalia catappa is medicinal plant that is used in ancient tradition in the treatment several diseases.

2. 2

   Diabetic retinopathy

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Behi T (2021)

     Excerpt Conclusion: TC reverses diabetes-induced retinopathy by anti-hyperglycemic, anti-oxidant, anti-angiogenic & anti-inflammatory actions, & thus has a potential to be used in diabetes-induced retinopathy. Terminalia catappa is renowned for its anti-inflammatory, antioxidant, anti-hyperglycemic and anti-angiogenic activity.

   • According to Behi T (2017)

     Excerpt Terminalia catappa has shown potent antidiabetic activity in the past; however, the exact molecular mechanisms by which it acts have not been elucidated. TC effectively attenuates the progression of diabetic retinopathy & shows significant hypoglycaemic actions.

   • According to Singh M (2023)

     Excerpt Terminalia catappa is a big spreading tree in strong winds. It is able to show antimicrobial, anti-inflammatory, antidiabetic, antioxidant, hepatoprotective, & anticancer activities.

   • According to Nagappan AN (2003)

     Excerpt Nagappan AN et al, Antidiabetic activity of Terminalia catappa Linn fruits.

   • According to Divya N (2019)

     Excerpt The aim of the present study was to determine the anti-diabetic effects of Terminalia catappa L. The ethanol extract (500 mg/kg) had significant anti-diabetic activity by altering blood glucose, glycosylated hemoglobin, liver glycogen, glucose 6-phosphatase, fructose 1,6-bisphosphatase, glucokinase, aspartate transaminase, alanine transaminase, alkaline phosphatase, urea, uric acid & creatinine levels while increasing insulin levels.

3. 3

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Behi T (2021)

     Excerpt Terminalia catappa is renowned for its anti-inflammatory, antioxidant, anti-hyperglycemic and anti-angiogenic activity. Conclusion: TC reverses diabetes-induced retinopathy by anti-hyperglycemic, anti-oxidant, anti-angiogenic & anti-inflammatory actions, & thus has a potential to be used in diabetes-induced retinopathy.

   • According to Singh M (2023)

     Excerpt Terminalia catappa is a big spreading tree in strong winds. It is able to show antimicrobial, anti-inflammatory, antidiabetic, antioxidant, hepatoprotective, & anticancer activities.

   • According to Nagappan AN (2003)

     Excerpt Nagappan AN et al, Antidiabetic activity of Terminalia catappa Linn fruits.

   • According to Divya N (2019)

     Excerpt The aim of the present study was to determine the anti-diabetic effects of Terminalia catappa L. The ethanol extract (500 mg/kg) had significant anti-diabetic activity by altering blood glucose, glycosylated hemoglobin, liver glycogen, glucose 6-phosphatase, fructose 1,6-bisphosphatase, glucokinase, aspartate transaminase, alanine transaminase, alkaline phosphatase, urea, uric acid & creatinine levels while increasing insulin levels.

   • According to Behi T (2017)

     Excerpt Terminalia catappa has shown potent antidiabetic activity in the past; however, the exact molecular mechanisms by which it acts have not been elucidated. Key findings: Apart from metabolic dysfunctions, several hyperglycaemia-induced pathological conditions come into scene as the after-effects of diabetes.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.