Tithonia diversifolia (Mexican sunflower) : medicinal properties in alcoholic extraction

Tithonia diversifolia (Mexican sunflower, Tournesol du Mexique) — family Asteracées.

Scientific synonyms : Helianthus quinquelobus-S. & M., Mirasolis diversifolia-H, Tithonia diversifolia var. glabriuscula-S.F. B., T triloba-S.B. ex K, Urbanisol tagetiflora var flavua-Kuntze.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 44 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kulsum U (n.d.)

     Excerpt Tithonia diversifolia leaves is one of plants traditionally used to control blood glucose level. The purpose of this study was to determine Antihyperglycemic activity of ethanol extract of kembang bulan leaves in Alloxan-induced white male rats Sprague Dawley strain.

   • According to Lin HR (2012)

     Excerpt Tithonia diversifolia is a well-known traditional Chinese medicine treating diabetes, hepatitis, & hepatocarcinoma but its molecular mechanism is not fully understood. These results highly indicated that tirotundin & tagitinin A are the active components of TD to exert anti-diabetic effect through PPARγ pathway.

2. 2

   Bacterial infection: Staphylococcus epidermidis, airborne Enterobacter, α-haemolytic Streptococcus, Bacillus cereus, Escherichia coli and γ-haemolytic Streptococcus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Swamy AT (2016)

     Excerpt From the study the plant Tithonia diversifolia was found to inhibit the growth of Staphylococcus epidermidis (36.80mm), Enterobacter aérogènes (31.20mm), Streptococcus α-Hemolytic (29.60mm), Bacillus Cereus (26.2mm), Escherichia coli (10.40mm) & Streptococcus γ-Hemolytic (0.000mm) The data collected and documented in this paper is a Scientifically justification that the plant can be used to treat against various diseases caused by Staphylococcus epidermidis & Enterobacter aérogènes. The study was conducted to analyze the antibacterial activity of Tithonia diversifolia leaves.

   • According to Fereira-Fargas AL (2019)

     Excerpt In the evaluation of the antimicrobial activity, bacterial strains of Staphylococcus aureus, Escherichia coli & Pseudomonas aeruginosa were used. The present study aimed to evaluate the chemical composition, antioxidant potential, & the cytotoxic & antimicrobial activity of the essential oil of the plant species Tithonia diversifolia (Hemsl) A.

   • According to REMOVE Taiwo (2007)

     Excerpt These isolates included 27 Staphylococcus sp., 15 Escherichia coli, 3 Klebsiella sp., 4 Proteus sp. The aim of this study is to investigate the antibacterial effects of two plant extracts, Citrus aurantifolia linn (lime) & Tithonia diversifolia poaceae (sunflower) commonly used as traditional medicines in Nigeria.

3. 3

   Cancer: adjuvant treatment for leukaemia

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Liao MH (2013)

     Excerpt Tagitinin C, a major sesquiterpenoid, was isolated from the leaves of Tithonia diversifolia. Treatment with tagitinin C isolated from TDM resulted in activation of both caspase 3 and caspase 8 which suggested that the antiproliferative effect of this compound was caspase-dependent apoptosis.

   • According to Kuroda M (2007)

     Excerpt Cytotoxicity-guided fractionation of the 80% EtOH extract of Tithonia diversifolia has resulted in the isolation of twelve sesquiterpenoids (1-12), including three new ones (4, 10, 12), & three known flavonoids (13-15). The cancer growth inhibitory property of 9, the main cytotoxic compound in TD was examined using a disease-oriented panel composed of 39 human cancer cell lines in the Japanese Foundation for Cancer Research,.

   • According to Gué JQ (2002)

     Excerpt Activity-guided fractionation of an ethyl acetate extract of the aerial parts of Tithonia diversifolia, using an antiproliferation bioassay performed with human colon cancer (Col2) cells, led to the isolation of three new sesquiterpenoids, 2alpha-hydroxytirotundin (1), tithofolinolide (2), and 3alpha-acetoxydiversifolol (3), along with eight known sesquiterpene lactones, 3beta-acetoxy-8beta-isobutyryloxyreynosin (4), tagitinin C (5), 1beta,2alpha-epoxytagitinin C (6), 4alpha,10alpha-dihydroxy-3-oxo-8beta-isobutyryloxyguaia-11(13)-en-12,6alpha-olide (7), 3alpha-acetoxy-4alpha-hydroxy-11(13)-eudesmen-12-oic acid methyl ester, 17,20-dihydroxygeranylnerol, tagitinin A,& tirotundin. These isolates were evaluated for their potential as cancer chemopreventive agents, by measuring antiproliferative activity in Col2 cells & induction of cellular differentiation in human promyelocytic leukemia (HL-60) cells.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.