Tithonia diversifolia (Mexican sunflower) : medicinal properties in alcoholic extraction

Tithonia diversifolia (Mexican sunflower, Tournesol du Mexique) — family Asteracées.

Scientific synonyms : Helianthus quinquelobus-S. & M., Mirasolis diversifolia-H, Tithonia diversifolia var. glabriuscula-S.F. B., T triloba-S.B. ex K, Urbanisol tagetiflora var flavua-Kuntze.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 88 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: above-ground parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pradiningsih A (2018)

     Excerpt Plants used for the treatment of diabetes, one of which is Daun Kembang Bulan (Tithonia diversifolia A. Diabetes mellitus becomes a major health problem because its complications are short & long term.

   • According to Istikharah R (2022)

     Excerpt In this study, we examined the anti-diabetic activity of standardised extracts of Tithonia diversifolia (Hemsley) A Gray leaf for their effects on insulin resistance & mitochondrial DNA (mtDNA) copy number. Conclusion: TD extract has the potential to be used as an anti-diabetic agent that improves insulin resistance, possibly by increasing mtDNA content.

   • According to Kulsum U (n.d.)

     Excerpt Tithonia diversifolia leaves is one of plants traditionally used to control blood glucose level. The purpose of this study was to determine Antihyperglycemic activity of ethanol extract of kembang bulan leaves in Alloxan-induced white male rats Sprague Dawley strain.

   • According to Chagas-Paula D.A (2012)

     Excerpt Biological studies are described to evaluate the anti-inflammatory, analgesic, antimalarial, antiviral, antidiabetic, antidiarrhoeal, antimicrobial, antispasmodic, vasorelaxant, cancer-chemopreventive, cytotoxic, toxicological, bioinsecticide, & repellent activities. A few of these studies have been carried out with isolated compounds from Tithonia species, but the majority has been conducted with different extracts.

   • According to Lin HR (2012)

     Excerpt Tithonia diversifolia is a well-known traditional Chinese medicine treating diabetes, hepatitis, & hepatocarcinoma but its molecular mechanism is not fully understood. These results highly indicated that tirotundin & tagitinin A are the active components of TD to exert anti-diabetic effect through PPARγ pathway.

2. 2

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pradiningsih A (2018)

     Excerpt Plants used for the treatment of diabetes, one of which is Daun Kembang Bulan (Tithonia diversifolia A. Diabetes mellitus becomes a major health problem because its complications are short & long term.

   • According to Istikharah R (2022)

     Excerpt In this study, we examined the anti-diabetic activity of standardised extracts of Tithonia diversifolia (Hemsley) A Gray leaf for their effects on insulin resistance & mitochondrial DNA (mtDNA) copy number. Conclusion: TD extract has the potential to be used as an anti-diabetic agent that improves insulin resistance, possibly by increasing mtDNA content.

   • According to Kulsum U (n.d.)

     Excerpt Tithonia diversifolia leaves is one of plants traditionally used to control blood glucose level. The purpose of this study was to determine Antihyperglycemic activity of ethanol extract of kembang bulan leaves in Alloxan-induced white male rats Sprague Dawley strain.

   • According to Chagas-Paula D.A (2012)

     Excerpt Biological studies are described to evaluate the anti-inflammatory, analgesic, antimalarial, antiviral, antidiabetic, antidiarrhoeal, antimicrobial, antispasmodic, vasorelaxant, cancer-chemopreventive, cytotoxic, toxicological, bioinsecticide, & repellent activities. A few of these studies have been carried out with isolated compounds from Tithonia species, but the majority has been conducted with different extracts.

   • According to Lin HR (2012)

     Excerpt Tithonia diversifolia is a well-known traditional Chinese medicine treating diabetes, hepatitis, & hepatocarcinoma but its molecular mechanism is not fully understood. These results highly indicated that tirotundin & tagitinin A are the active components of TD to exert anti-diabetic effect through PPARγ pathway.

3. 3

   Bacterial infection: Staphylococcus epidermidis, aerogenic Enterobacter, Shigella spp., α-haemolytic Streptococcus, Bacillus cereus, Salmonella spp., Pseudomonas aeruginosa, Escherichia coli and Enterococcus spp.

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Swamy AT (2016)

     Excerpt From the study the plant Tithonia diversifolia was found to inhibit the growth of Staphylococcus epidermidis (36.80mm), Enterobacter aérogènes (31.20mm), Streptococcus α-Hemolytic (29.60mm), Bacillus Cereus (26.2mm), Escherichia coli (10.40mm) & Streptococcus γ-Hemolytic (0.000mm) The data collected and documented in this paper is a Scientifically justification that the plant can be used to treat against various diseases caused by Staphylococcus epidermidis & Enterobacter aérogènes. The study was conducted to analyze the antibacterial activity of Tithonia diversifolia leaves.

   • According to Fereira-Fargas AL (2019)

     Excerpt In the evaluation of the antimicrobial activity, bacterial strains of Staphylococcus aureus, Escherichia coli & Pseudomonas aeruginosa were used. The present study aimed to evaluate the chemical composition, antioxidant potential, & the cytotoxic & antimicrobial activity of the essential oil of the plant species Tithonia diversifolia (Hemsl) A.

   • According to Ferreira-Farias AL (2019)

     Excerpt In the evaluation of the antimicrobial activity, bacterial strains of Staphylococcus aureus, Escherichia coli & Pseudomonas aeruginosa were used. The present study aimed to evaluate the chemical composition, antioxidant potential, & the cytotoxic & antimicrobial activity of the essential oil of the plant species Tithonia diversifolia (Hemsl) A.

   • According to Agboola O.O (2016)

     Excerpt coli> Proteus mirabi> Bacillus megaterium> Klebsiella pneumonia> Bacillus cereus> Streptococcus pyrogens. At 5 mg/ml, only Bacillus megaterium & Bacillus cereus were inhibited of all gram-positive bacteria while Streptococcus pyrogens was unaffected.

   • According to Taiwo (2007)

     Excerpt These isolates included 27 Staphylococcus sp., 15 Escherichia coli, 3 Klebsiella sp., 4 Proteus sp. The aim of this study is to investigate the antibacterial effects of two plant extracts, Citrus aurantifolia linn (lime) & Tithonia diversifolia poaceae (sunflower) commonly used as traditional medicines in Nigeria.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.