Tribulus terrestris (Pagôt) : medicinal properties in alcoholic extraction

Tribulus terrestris (Pagôt, Maltese Cross, Croix-de-Malte) — family Zygophyllacées.

Scientific synonyms : Tribulus lanuginosus-L, T saharae-A. Chew, T terrestris var sericeus-Anders. ex-Svenson.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 20 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 136 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lamba HS (2011)

     Excerpt Objective: Reported study was done for a comparative evaluation of α-glucosidase & aldose reductase inhibitory activity of Tribulus terrestris & Curculigo orchioides which are well-known Ayurvedic Rasayana herbs. Design: A total of 48 Wistar strain rats were rendered hyperglycemic by treating them with streptozotocin (75 mg/Kg body weight).

   • According to Kamenov Z (2017)

     Excerpt The primary objectives were to compare the efficacy of extracts of the plant Tribulus terrestris (TT; marketed as Tribestan), in comparison with placebo, for the treatment of men with erectile dysfunction (ED) & with or without hypoactive sexual desire disorder (HSDD), as well as to monitor the safety profile of the drug. Each Tribestan film-coated tablet contains the active substance Tribulus terrestris, herba extractum siccum (35–45:1) 250 mg which is standardized to furostanol saponins (not less than 112.5 mg).

   • According to Li M (2002)

     Excerpt RESULTS: The level of serum glucose could be significantly reduced by saponin from Tribulus terrestris, which was the rate of 26.25% & 40.67% in normal mice and diabetic mice in respectively. To study the hypoglycemic effect of saponin from Tribulus terrestris L.

   • According to Rahman A (2023)

     Excerpt The present research aimed at the biosynthesizing of silver nanoparticles (AgNPs) using Tribulus terrestris seed extract as the reducing & stabilizing agent & investigating their anti-diabetic properties. Furthermore, the in vivo antidiabetic study was performed on TT-AgNPs in streptozotocin-induced diabetic mice.

   • According to Louveaux A, (1998)

     Excerpt To study the hypoglycemic effect of saponin from Tribulus terrestris METHOD: Alloxan was used to establish the diabetic model in mice. RESULTS: The level of serum glucose could be significantly reduced by saponin from Tribulus terrestris, which was the rate of 26.25% & 40.67% in normal mice & diabetic mice in respectively.

2. 2

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lamba HS (2011)

     Excerpt Objective: Reported study was done for a comparative evaluation of α-glucosidase & aldose reductase inhibitory activity of Tribulus terrestris & Curculigo orchioides which are well-known Ayurvedic Rasayana herbs. Design: A total of 48 Wistar strain rats were rendered hyperglycemic by treating them with streptozotocin (75 mg/Kg body weight).

   • According to Kamenov Z (2017)

     Excerpt The primary objectives were to compare the efficacy of extracts of the plant Tribulus terrestris (TT; marketed as Tribestan), in comparison with placebo, for the treatment of men with erectile dysfunction (ED) & with or without hypoactive sexual desire disorder (HSDD), as well as to monitor the safety profile of the drug. Each Tribestan film-coated tablet contains the active substance Tribulus terrestris, herba extractum siccum (35–45:1) 250 mg which is standardized to furostanol saponins (not less than 112.5 mg).

   • According to Li M (2002)

     Excerpt RESULTS: The level of serum glucose could be significantly reduced by saponin from Tribulus terrestris, which was the rate of 26.25% & 40.67% in normal mice and diabetic mice in respectively. To study the hypoglycemic effect of saponin from Tribulus terrestris L.

   • According to Rahman A (2023)

     Excerpt The present research aimed at the biosynthesizing of silver nanoparticles (AgNPs) using Tribulus terrestris seed extract as the reducing & stabilizing agent & investigating their anti-diabetic properties. Furthermore, the in vivo antidiabetic study was performed on TT-AgNPs in streptozotocin-induced diabetic mice.

   • According to Louveaux A, (1998)

     Excerpt To study the hypoglycemic effect of saponin from Tribulus terrestris METHOD: Alloxan was used to establish the diabetic model in mice. RESULTS: The level of serum glucose could be significantly reduced by saponin from Tribulus terrestris, which was the rate of 26.25% & 40.67% in normal mice & diabetic mice in respectively.

3. 3

   Bacterial infection: Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Salmonella typhi, Klebsiella pneumoniae and Bacillus subtilis

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mohammed MJ (2008)

     Excerpt In this study, the saponin compounds were isolated from Tribulus terrestris (Fruit), & to determine the inhibitory effect of these compounds were investigated on the growth of some bacteria, which include: Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Salmonella typhi, Klebsiella pneumonia & Bacillus subtilis, & used the antibiotics (Ciprofloxacin, Chloramphenicol) as control samples.

   • According to Al-Bayati FA (2008)

     Excerpt Antimicrobial activity of organic and aqueous extracts from fruits, leaves & roots of Tribulus terrestris L., an Iraqi medicinal plant used as urinary anti-infective in folk medicine, was examined against 11 species of pathogenic & non-pathogenic microorganisms: Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Corynebacterium diphtheriae, Escherichia coli, Proteus vulgaris, Serratia marcescens, Salmonella typhimurium, Klebsiella pneumoniae, Pseudomonas aeruginosa & Candida albicans using microdilution method in 96 multiwell microtiter plates.

   • According to Zhang J-D (2005)

     Excerpt We have isolated eight steroid saponins from Tribulus terrestris L., namely TTS-8, TTS-9, TTS-10, TTS-11, TTS-12, TTS-13, TTS-14 & TTS-15. So in vivo activity of TTS-12 in a vaginal infection model with fluconazole-resistant C.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.