Vigna unguiculata (Black-eyed Pea) : medicinal properties in alcoholic extraction

Vigna unguiculata (Black-eyed Pea, Chickpea, String Bean, Pigeon Pea, Rigwaz Pea, Chic pea, String pea, Rigoise pea, Pwa Zié-nwè, Pwa-chik, Pwa-fisèl, Pwa-pijon, Pwa-rigwaz, Pois-à-yeux-noirs, Pois-chique, Pois-ficelle, Pois-à-pigeon, Pois-rigoise) — family Fabacées.

Scientific synonyms : Dolichos biflorus-L, Vigna catang-(Burm f.)-Walp, V sesquipetalis-Fraw, V sinensis-(L)-S & Hassk.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 95 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for breast cancer

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Gutierrez-Uribe J (2011)

     Excerpt The phenolic profile & anticancer properties of extracts from whole cowpeas, seed coats and cotyledons were determined. (GAE)/l inhibited 65% the proliferation of hormone-dependent mammary (MCF-7) cancer cells.

   • According to Panzeri D (2020)

     Excerpt In this study, for the first time Vigna unguiculata L. (cowpea) water boiled seed extracts were found to reduce the viability of different colorectal cancer (CRC) cell lines, such as E705, DiFi and SW480 & the proliferation of Caco-2 line too, without affecting CCD841 healthy cell line.

   • According to Lee SM (2011)

     Excerpt Anti-inflammatory effects of methanol extract & solvent fractions of cowpea (Vigna sinensis K.; VS) seeds & the isolated compounds were evaluated. LA suppressed the production of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, & tumor necrosis factor (TNF)-α in LPS-induced macrophage cells.

   • According to Awika JM (2017)

     Excerpt Evidence suggests significant anti-inflammatory effect, & benefits against cancer, diabetes, & cardiovascular disease of cowpea polyphenols & peptides, with potential synergistic interactions.

   • According to Kitadi JM (2019)

     Excerpt In the present review the aim was to gather the information related to nutritional value, phytochemistry & biological activities of Vigna unguiculata. In the conclusion, the present review can, therefore, help to inform future scientific research towards the development of novel drugs of relevance from V Unguiculata to improve human health & wellbeing.

2. 2

   Oxidative stress

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Khusniyati E (2014)

     Excerpt Unguiculata, VU) able to reduced oxidative stress in cardiac & modulate the aorta estrogen receptor of ovariectomized rats. unguiculata is an alternative therapy in decreasing cardiac oxidative stress in ovariectomized rats.

   • According to Shakir T (2013)

     Excerpt Cholinergic & cerebral blood flow deficits, excessive levels of oxidative stress, neuroinflammation & glutamate excitatory mechanisms are all believed to contribute to the development & progression of the disease. Scoparia dulcis, Catharanthus roseus, Sesamum indicum, Erythrina senegalensis & Vigna Unguiculata represent five plants that have been used as traditional medicines for the treatment of AD in certain cultures.

   • According to Avanza MV (2021)

     Excerpt This work presents a green, downstream process, from extraction to phytochemical characterization & bioactivity testing, to obtain & evaluate the functional properties of phenolic compounds from cowpea (Vigna unguiculata seeds & pods. The main factors affecting the extraction conditions (temperature & solvent) were optimized in order to attain extracts with the highest extraction yield, antioxidant capacity, & total phenolic content.

   • According to Zia-Ul-Haq M (2005)

     Excerpt The present investigation has been carried out to determine the antioxidant activity of the methanolic extracts obtained from four cultivars of cowpea (Vigna unguiculata (L) Walp.) seeds. Phenolic compounds present in the extracts showed the antioxidant & antiradical properties when investigated using a linoleic acid peroxidation model, FRAP, ORAC & TRAP assays, as well as DPPH, hydroxyl, nitric oxide & superoxide radical scavenging activity.

   • According to Vats S (2012)

     Excerpt The ethyl acetate fraction of callus was evaluated for its antimicrobial & antioxidant activity.

3. 3

   Fungal infection: Alternaria alternata, Fusarium proliferatum (‘Bechwana White’ and ‘Kpodjiguégué’ cultivars)

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kritzinger Q (2005)

     Excerpt Acetone & ethanol extracts of the leaves of Bechwana White (BW) & Kpodjiguégué (Kpod) cultivars were investigated for their antimicrobial properties against bacterial & fungal pathogens. Alternaria alternata was significantly reduced by both BW extracts at 2.5mg ml− 1 whereas only the ethanol extract showed antifungal activity against Fusarium proliferatum at the same concentration.

   • According to Zia-Ul-Haq M (2010)

     Excerpt The physiochemical properties and fatty acid (FA) composition of oil from seeds of 4 cowpea cultivars viz., Elite, CP1, White Star & SA dandy, commonly grown in Pakistan, were investigated. Despite variations unsaturated fatty acids were observed as being present in higher concentration in all cultivars.

   • According to Perchuk I (2020)

     Excerpt Gas chromatography with mass spectrometry was used to compare metabolomic profiles of seeds & pods yielded by old Chinese landraces & the modern cultivars 'Yunanskaya' & 'Sibirskiy razmer'. Landraces manifested higher protein content in pods, while modern cultivars had pods with higher contents of organic acids, polyols, monosaccharides, & fatty acids.

   • According to Zia-Ul-Haq M (2005)

     Excerpt The present investigation has been carried out to determine the antioxidant activity of the methanolic extracts obtained from four cultivars of cowpea (Vigna unguiculata (L) Walp.) seeds.

   • According to Ye XY (2000)

     Excerpt The two proteins, designated alpha- & bêta-antifungal proteins in accordance with their order of elution from the CM-Sepharose column, were capable of inhibiting human immunodeficiency virus (HIV) reverse transcriptase & one of the glycohydrolases associated with HIV infection, alphaglucosidase, but bêta-glucuronidase was not repressed.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.