Zingiber officinale (Jenjanb) : medicinal properties in alcoholic extraction

Zingiber officinale (Jenjanb, Ginger, Gingembre) — family Zingiberacées.

Scientific synonyms : Amomum zingiber-L, Curcuma longifolia-Wall, Zingiber aromaticum-N, Z majus-Rumph, Z missionis-W, Z sichuanense-Z.Y. Zhu, Z zingiber-(L)-H.K..

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 36 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 134 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: Adjuvant treatment for breast, pancreatic and liver cancer, meningioma and cholangiocarcinoma (CCA); Ayurvedic formulation KANCHAR GUGGULU: Methotrexate-like

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bardi DA (2013)

     Excerpt Zingiber officinale is a traditional medicine against various disorders including liver diseases. In group 1 rats received intraperitoneal (i.p.) injection of normal saline while groups 2-5 received thioacetamide (TAA, 200 mg/kg; i.p.) for induction of liver cirrhosis, thrice weekly for eight weeks.

   • According to TAVAKOL A J (2010)

     Excerpt The aim of this study was to investigate the antitumor effect of Z officinale on hepatocellular Carcinoma cell lines. Hepatocellular Carcinoma (HCC, also called malignant hepatoma) is a primary malignancy (cancer) of the liver.

   • According to Ekowati H (2013)

     Excerpt Curcuma Xanthorrhiza, Curcuma longa & Zingiber officinale are commonly used as herbals in Indonesia & around the world. officinale has a protective effect in rats against liver damage induced by doxorubicin.

   • According to Ahmad N (2006)

     Excerpt Treatment groups consisted of rats fed with Ginger extract at 100 mg/kg body weight (Ginger group), rats induced with liver cancer by choline deficient diet plus ethionine in drinking water (CDE group) & rats with CDE diet plus Ginger extract (CDE + Ginger group). From this study, it can be concluded that free radicals are increased in liver Carcinogenesis (as evidenced by an increase in SOD activity) & Ginger extract exhibits anticancer effect by scavenging the free radicals (decrease in SOD activity).

   • According to AKINLOYE OA (2014)

     Excerpt AKINLOYE OA et al, ANTICLASTOGENIC & HEPATOPROTECTIVE PROPERTIES OF GINGER (ZINGIBER OFFICINALE) EXTRACT AGAINST NITROBENZENE-INDUCED TOXICITY IN RATS, Rom Jl Biochem, 51(1) :3-15, 2014.-Ginger or Zingiber officinale has been reported to possess antioxidant activities that can protect against free radical damage. officinale extract possesses Anticlastogenic and hepatoprotective properties against NB-induced toxicity.

2. 2

   Type II diabetes mellitus

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nammi S (2009)

     Excerpt Metabolic syndrome, including obesity, dyslipidaemia, hyperglycaemia & insulin resistance that predisposes type 2 diabetes is a major disease problem around the world & a plethora of herbal medicines are claimed to be effective in controlling these disorders. The rhizome of Zingiber officinale (Zingiberaceae) is commonly used as a spice in various foods and beverages.

   • According to Akhani SP (2004)

     Excerpt The fresh & dried rhizome of Zingiber officinale Roscoe (commonly known as ginger) is widely used in traditional medicine. In an oral glucose tolerance test, treatment with ZO was found to decrease significantly the area under the curve of glucose & to increase the area under the curve of insulin in STZ-diabetic rats.

   • According to HADIBRATA E (2025)

     Excerpt Results: The results of this study indicate that the administration of red ginger ethanol extract at a dose of 400mg/kgBB or 600mg/kgBB has the same potential as sildenafil in increasing the libido of diabetic rat models. To compare the effect of red ginger ethanol extract & Sildenafil on increasing the libido of diabetic rat models and determine the dose that significantly affects the increase in libido of diabetic rat models.

   • According to RANTI I (2023)

     Excerpt The present work investigated the preventive & attenuating effects of ethanolic extracts of Phyllanthus acidus (PA) & Zingiber aromaticum (ZA) against metabolic disturbances in a high-fat high-fructose (HFHF) diet-induced obesity model. The HFHF diet significantly increased BMI, adiposity index, triglycerides, cholesterol, fasting glucse, insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), leptin, malondialdehyde (MDA) compared with the standard diet.

   • According to Huang FY (2019)

     Excerpt Ancient medical practitioners used to encourage dietary supplements and herbal medicine for the treatment of type 2 diabetes mellitus (T2DM). Ginger (Zingiber officinale), is a nontoxic spice with negligible side effects, & is considered safe by the food and drug administration.

3. 3

   Liver problems caused by doxorubicin

   Plant part used: Rhizome. Mentioned synergistic association: curcuma longa, Curcuma zedoaria.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ekowati H (2013)

     Excerpt Curcuma Xanthorrhiza, Curcuma longa & Zingiber officinale are commonly used as herbals in Indonesia & around the world. officinale has a protective effect in rats against liver damage induced by doxorubicin.

   • According to Bardi DA (2013)

     Excerpt Zingiber officinale is a traditional medicine against various disorders including liver diseases. In group 1 rats received intraperitoneal (i.p.) injection of normal saline while groups 2-5 received thioacetamide (TAA, 200 mg/kg; i.p.) for induction of liver cirrhosis, thrice weekly for eight weeks.

   • According to AKINLOYE OA (2014)

     Excerpt AKINLOYE OA et al, ANTICLASTOGENIC & HEPATOPROTECTIVE PROPERTIES OF GINGER (ZINGIBER OFFICINALE) EXTRACT AGAINST NITROBENZENE-INDUCED TOXICITY IN RATS, Rom Jl Biochem, 51(1) :3-15, 2014.-Ginger or Zingiber officinale has been reported to possess antioxidant activities that can protect against free radical damage. officinale extract possesses Anticlastogenic and hepatoprotective properties against NB-induced toxicity.

   • According to TAVAKOL A J (2010)

     Excerpt Recently, the biological activities of Zingiber officinale plants have been reported as possessing antitumor, antibacterial, anti-ulcer, antifungal, & Insecticidal properties. Most cases of HCC are secondary to either a viral hepatitis infection (hepatitis B or C) or cirrhosis (alcoholism being the most common cause of hepatic cirrhosis.

   • According to Ahmad N (2006)

     Excerpt Ginger or Zingiber officinale which is used in traditional medicine has been found to possess antioxidant effect that can control the generation of free radicals. Treatment groups consisted of rats fed with Ginger extract at 100 mg/kg body weight (Ginger group), rats induced with liver cancer by choline deficient diet plus ethionine in drinking water (CDE group) & rats with CDE diet plus Ginger extract (CDE + Ginger group).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.