Acacia farnesiana (Akasia jôn) : medicinal properties in alcoholic extraction

Thirupal  B et al, Antimicrobial screening of Acacia farnesiana (L.) Willd. Indian J Bot Res 2008;4(2):249-51

Bobbaraia V et al, Antimicrobial Screening of Acacia farnesiana (l.) Willd.Research-Gate, 2008-Abstract: Acacia farnesiana (L.) Willd (Mimosaceae). A wild plant growing in Eswaramala forest of Ananatapur District of Andhra Pradesh is used by the local people, against various ailments like cough & cold. In the present paper the different extracts obtained from the fruits of Acacia farnesiana exhibited a broad spectrum of Antimicrobial activity. The benzene, chloroform, methanol, & water extracts were active against gram-positive bacteria like Bacillus cereus, Micrococcus roseus, Staphylococc…

Misar A et al, Antidiarrhoeal activity of methanolic extract of Acacia farnesiana bark. Asian J of Chem, 2011. 23(4):1767-70-

Kadam RK et al, Study of Alcoholic Extract of Acacia Farnesiana (L.) Willd Pods, Research-Gate, 2021-Abstract: Identification of bioactive compound from alcoholic extract of Acacia farnesiana leguminosae pods by using preliminary phytochemical test or thin layer chromatography & the quantification of total phenolic content by folin-ciocalteu reagent method. shade dried grounded powder of AF pods was successively extracted with petroleum ether, chloroform & alcohol in Soxhlet apparatus, alcoholic compound obtained in more amount as compare to other two extract so alcoholic extract was used f…

Hernandez-Garcia E et al, Nuclear magnetic resonance spectroscopy data of isolated compounds from Acacia farnesiana (L) Willd fruits & two esterified derivatives, Data Brief, 22:255-68, 2018-Abstract:In the present article we describe the spectroscopic data of 1H & 13C Nuclear Magnetic Resonance of 11 compounds including: Nine natural products from the hexanic-chloroformic & methanolic extracts of Acacia farnesiana fruit& two esterified derivatives (22E-stimasta-5,22-dien- 3β-acetyl & methyl 3,4,5-triacetyloxybenzoate). Data linked to the research work entitled :Chemical composition of frui…

Sanchez E et al, Isolation, characterization & mode of antimicrobial action against Vibrio cholerae of methyl gallate isolated from Acacia farnesiana. J Appl Microbiol, 2013;115(6):1307-16.

Mors WB et al, Plant natural products as active against snake-bite molecular approach. Phytochemistry. 2000. 55:627-42-

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Bino Kingsley R et al, Pharmacodynamic studies on the isolated active fraction of Acacia farnesiana (L.) willd, Pharmacogn Mag, 2014; 10(Suppl2)-doi: 10.4103/0973-1296.133277-

Udomslip J et al, Antifungal properties of essential oils from Thai medical plants against rice pathogenic fungi Asian J of Food & Agro-Industry, 2009, Special Issue, S24-S30-Abstract: This in vitro study was aimed to evaluate the mycelium growth and spore germination inhibition properties of essential oils. Two Thai medicinal plants; Frankincense oil (Boswellia carteri Bird.) & Cassia oil (Acacia farnesiana Linn) were applied against 7 species of economically important rice pathogenic fungi; Alternaria brassicicola, Aspergillus flavus, Bipolaris oryzae, Fusarium moniliforme, Fusarium proli…

Trivedi CP et al, Bronchodilator & antiinflammatory effect of glycosidal fraction of Acacia farnesiana. Indian J of Physiol & Pharmacol. 1986. 30(3):267-8.

Meckes M et al, Activity of some Mexican medicinal plant extracts on carrageenan-induced rat paw edema / Phytomed,11 (5) :446-51, 2004-Abstract: The extracts obtained from 14 plants of the Mexican medicinal flora were assessed for anti-inflammatory activity by carrageenan-induced rat paw edema model. The i.p. administration of the extracts at a dose of 400 mg/kg produced a high reduction of edema with 70% of the plant extracts. Oenothera rosea methanol extract, Sphaeralcea angustifolia chloroform extract, Acacia farnesiana, Larrea tridentata & Rubus coriifolius methanol extracts as well as …

Mueller M et al, ANTI-INFLAMMATORY, ANTIBACTERIAL, & ANTIOXIDANT ACTIVITIES OF THAI MEDICINAL PLANTS Inter J of Pharm & Pharmaceut Sci, 7 :11, 2015.

Hukkeri VI et al, Antiinflammatory activity of leaves of Acacia farnesiana Willd. Indian drug. 2002. 39(12):664-6-Abstract : Acacia farnesiana is used in the traditional systems of medicine for treating inflammations. In the present study the ethanolic extract of leaves of Acacia farnesiana was tested for the anti-inflammatory activity by carrageenan induced paw oedema for acute inflammation & cotton pellet induced granulation for chronic inflammatory model. The ethanolic extract showed significant anti-inflammatory activity in both the models studied,

Ashraf Mohd Salleh M et al, ACACIA HONEY INDUCES APOPTOSIS IN HUMAN BREAST ADENOCARCINOMA CELL LINES (MCF-7),, UTM J Teknologi, 79:4, 2017-Abstract: Apoptosis is one of markers considered in drug design including in treating cancers. Conventional treatments for cancer cause various side effects. One of possible alternatives is honey, an antioxidant driven by its phenolic & flavonoids content. This study aims to observe the effects of Malaysian Acacia honey in inhibiting breast cancer cell growth through apoptosis. Antioxidant properties of the honey were measured using total phenolic conten…

Amalia MM et al, Lead bioaccumulation in Acacia farnesiana & its effect on lipid peroxidation & glutathione production. Plant Soil 2011;339(1):377-89.

Delgadillo-Puga C et al, Phenolic Compounds in Organic & Aqueous Extracts from Acacia farnesiana Pods Analyzed by ULPS-ESI-Q-oa/TOF-MS. In Vitro Antioxidant Activity & Anti-Inflammatory Response in CD-1 Mice, Mol, 23(9):2386, 2018-Abstract: Acacia farnesiana (AF) pods have been traditionally used to treat dyspepsia, diarrhea & topically for dermal inflammation. Main objectives: (1) investigate the antioxidant activity & protection against oxidative-induced damage of six extracts from AF pods & (2) their capacity to curb the inflammation process as well as to down-regulate the pro-inflammato…

Ferreira Abrantes V E et al, Molecular Modeling of Lectin-Like Protein from Acacia farnesiana Reveals a Possible Anti-Inflammatory Mechanism in Carrageenan-Induced Inflammation BioMed Res Inter, 2013-Abstract: Acacia farnesiana lectin-like protein (AFAL) is a chitin-binding protein has been classified as phytohaemagglutinin from Phaseolus vulgaris (PHA). Legume lectins are examples for structural studies, & this family of proteins shows a remarkable conservation in primary, secondary, & tertiary structures. Lectins have ability to reduce the effects of inflammation caused by phlogistic agen…

Ramli S et al, Antioxidant, Antimicrobial & Cytotoxicity Activities of Acacia farnesiana (L.) Willd. Leaves Ethanolic Extract, Pharmacogn J, 3(23- :50-8,, 2011-Abstract: The antioxidant activity was evaluated from the ability to chelate iron, reducing property, scavenging DPPH radical & nitric oxide. The A. farnesiana ethanolic extract responded to all the antioxidant assays in concentrations dependent manner. Evaluated by broth microdilution assay, the extract exhibited MIC value at 0.8 mg/ml against Bacillus subtilis & MIC value at 2.5 mg/ml against Saccharomyces cerevisiae. The absence o…

LEAL LS et al, The anti-inflammatory & antinociceptive effects of proteins extracted from Acacia farnesiana seeds, Rev. bras. plantas med. 18 no.1 Botucatu 2016-Abstract: The present work aimed to evaluate the anti-inflammatory & analgesic activities of proteins obtained from AF seeds. Five different protein fractions (albumin, globulin, prolamin, acidic & basic glutelins) were obtained & investigated for the protein pattern, the presence of hemagglutinating & proteolytic activities. The globulin fraction (GLB) was also evaluated for anti-inflammatory & analgesic activities. Globulins reduc…

Lin AS et al. Acasiane A & B & farnesirane A & B, diterpene derivatives from the roots of Acacia farnesiana. Planta Medica. 2009. 75(3):256-61-Abstract: Four new diterpenes, acasiane A ( 1), acasiane B ( 2), farnesirane A ( 3), & farnesirane B ( 4), along with three known diterpenes ( 5 - 7), two triterpenes ( 8 & 9), & eight flavonoids ( 10 - 17) were isolated from the roots of Acacia farnesiana. The structures & relative configurations of these compounds were determined by various spectroscopic & x-ray analyses. All isolated compounds were evaluated for their in vitro cytotoxic activities…

de la Cruz S et al, ACUTE TOXICITY & DECREASED PERISTALSIS IN MICE CAUSED BY TAXODIUM MUCRONATUM & ACACIA FARNESIANA EXTRACTS,  Rev. Latinoamer. Quím., 2012; 40(1)-Abstract : Diarrheal diseases remain a health problem in Mexico & the world. Taxodium mucronatun Ten. (Taxodiaceae) (Ahuehuete, Sabino) & Acacia farnesiana (L.) Will. (Leguminosae) (Huizache) are popularly used in the treatment of diarrhea. The aim of this work was to determine, in vivo, the lethal media doses & effect on intestinal propulsion of aqueous & ethanol extracts from leaves & small stems in mice. The lethal media doses…

Tengku N et al, Inhibition of acetylcholinesterase & NADH oxidase by Acacia farnesiana, Panacea J of Pharm & Pharmaceut Sci, 2013; 1(1): 6-8-Abstract: Physiological role of NADH oxidase is to reduce oxygen & to catalyse different reactions in the living system. Acetylcholinesterase catalyzes the hydrolysis of the neurotransmitter acetylcholine and termination of the nerve impulse in cholinergic synapses. Absence of evidence on acetylcholinesterase & NADH oxidase inhibitory activity of Acacia farnesiana let us embark on this study with an aim to scientifically prove the traditional claim of …

Dwarakanath V et al, ANTI ULCER ACTIVITY OF ACACIA FARNESIANA (L.) (AROMA) A LESSER-KNOWN FOLK - MEDICINAL PLANT, Inter J of Pharm & Biol Scie, 2013; 3(1):145-152-Abstract: To determine the pharmacological activity relevant to ulcer healing of Acacia farnesiana (aroma) leaf, a folk medicine used in the treatment of Ulcer. Materials & Methods: MEAF extract was done by using soxhelet apparatus & was further subjected to screening of the qualitative analysis of phyto chemicals. Consequently the Methanolic extract of leaf was tested against ulcer induced rats.  Results: The methanol extract of …

Konwar M et al, Comparative Study of Antidiabetic d Antioxidant Activities of the Ethanolic Extracts of Leaves & Bark of Acacia farnesiana (L.) Willd. in Streptozocin Induced Type 1 Diabetic Experimental Animal Models, Indian J of Pharmacol, 46(4): S4-S4, 2014-Abstract: The present study was carried out to evaluate the antidiabetic and antioxidant effect of the ethanolic extract of the leaves & bark of Acacia farnesiana (L.) Willd. in streptozotocin induced type1 diabetic animal model & also to explore the probable mechanism of their activities. Materials & methods.: A single intraperitonea…

SOUL SHEKHAR SP et al, ANTIPROLIFERATIVE & DNA CLEAVAGE ACTIVITY OF VARIOUS SOLVENT EXTRACTS OF ACACIA FARNESIANA LINN. POD, Asian J Pharm Clin Res,10(9), 2017:197-201-Abstract: Cancer has become the major disease by uncontrolled cell growth effecting large population on the globe. This study, deals with antiproliferative activity of different solvent extracts, viz., n-hexane (S1), dichloromethane (DCM) (S2), & methanol (S3) of Acacia farnesiana pod on four cancer cell lines, viz., chronic myelogenous leukemia (K562), breast cancer (MCF-7), hepatocellular carcinoma (HePG2), colorectal adeno…

Sally A et al, Searching for a natural herbicide: the role of medicinal plants,School of Land & Food Sci, Univ of Queensland, 4072.

Hanumantharao Y et al, Characterization & defluoridation studies using activated Acacia farnesiana carbon as adsorbent. Electron J Environ Agric Food Chem 2012;11:442-58-Abstract : Batch adsorption dynamics and equilibrium studies for the removal of Fluoride ions from aqueous solution using indigenously prepared Acacia farnesiana carbon (AFC), has been carried out under various experimental conditions at room temperature (30±1°C). Results found that percentage removal of Fluoride (F-) ions is increased with the decrease in initial concentration & is increased with increase in contact time i…

Katagi K et al, Occurrence of Cyclopropenoid Fatty Acids in Acacia Farnesiana Seed Oil & its Possible Industrial Utilization INDIAN J OF APPLIED RES, 3 :5, 2013-Abstract: In this work the presence of unusual fatty acids ; cyclopropenoid fatty acids (CPFAs) in the seed oil of Acacia fernesiana (AF) is detected along with other normal fatty acids. These fatty acids were characterized by spectral support & chemical degradation methods. The CPFAs have been characterized as 7-(2-octacyclopropen-1-yl) hepta- noic acid (malvalic acid) & 8-(2-octacyclopropen-1-yl) octanoic acid (sterculic acid) are…

Sahu N.P et al, 7,3'-dihydroxy-4'-methoxyflavone from seeds of Acacia farnesiana. Phytochem. 1998; 49:1425-6.

Gravito G et al, Antimalarial activity of some Colombian medicinal plants,

Seigler D.S et al, Cyanogenesis in Acacia farnesiana. Phytochem,  18 : 1389-90, 1979,

Khaleghi Ghadiri M et al, Review of Impotence: Natural remedies for impotence in medieval Persia, Inter J of Impotence Res, (2004) 16, 80–83 & 2004-

Barakat H.H et al, Flavonoid galloyl glucosides from the pods of Acacia farnesiana. Phytochem. 1999; 51:139-42-

El-Negoumy S.I et al, Kaempferol 7-galloylglucosa from Acacia farnesiana. Egyptian J of Chem, 24 : 471-3. 1982-

Heba HB et al, Flavonoid galloyl glucosides from the pods of Acacia farnesiana. Phytochem, 1999;51(1):139-42.

Biradar S et al, Qualitative Analysis of Legume Pericarp (Pod Wall) and Seeds of Acacia Farnesiana L. IOSR J of Pharm & Biol Sci, 6 (3): 43-6, 2013-

Zarra-Albaran MA et al, Galloyl flavonoids from Acacia farnesiana pods possess potent anthelmintic activity against Haemonchus contortus eggs & infective larvae, J of Ethnopharmacol, 249 :112402, 2020-Abstract : Acacia farnesiana (L.) Willd is a shrub legume used as condiment, medicinal plant & bioactive herbage. This species is used in traditional medicine of several countries to relieve the symptoms of gastrointestinal diseases, diarrhoea, stomach pain & typhoid as well as astringent, antidysenteric & anthelmintic. Some studies have shown that this plant displayed anthelmintic activity ag…

El Sissi H.I et al, Prunin-O-6"-gallat, aus Acacia farnesiana. Phytochem. 1974; 13:2843-4-

Srikanth M et al, EVALUATION OFIN VITRO ANTI UROLITHIATIC ACTIVITY OF ACACIA FARNESIANA, WORLD J OF PHARM & PHARMACEUT SCI, 2017; 6(11)-Abstract:

Sahu N.P et al, A novel diterpene glycoside from the seeds of Acacia farnesiana. Tetrahedron Letters. 1997; 38:8405-8-

REDDY B T et al, ANTIMICROBIAL SCREENING OF ACACIA FARNESIANA (L.) WILLD.

Parrotta JA et al, Acacia farnesiana (L.) Willd. sweet acacia / FABACEAE , Biological Scientist, Res & Development, U.S. Department of Agric Forest Service, Washington, DC 20090-6090-

SANTI-GADELHA T et al. Purification of a PHA-Like chitin-binding protein from Acacia farnesiana seeds: A Time-dependent oligomerization protein. Applied Biochem & Biotechnol, 150,.97-11, 2003-Abstract : A lectin-like protein from the seeds of Acacia farnesiana was isolated from the albumin fraction, characterized, and sequenced by tandem mass spectrometry. The albumin fraction was extracted with 0.5 M NaCl, and the lectin-like protein of A. farnesiana (AFAL) was purified by ion-exchange chromatography (Mono-Q) followed by chromatofocusing. AFAL agglutinated rabbit erythrocytes and did not a…

Medikondu K et al, CHARACTERIZATION AND DEFLUORIDATION STUDIES USING ACTIVATED ACACIA FARNESIANA CARBON AS ADSORBENT, EJEAFChe, 11 (5), 2012. [442‐458]-

Wassel G.M et al, Study of phenolic constituents & tannins isolated from Acacia nilotica (L.) Willd & Acacia farnesiana (L.) Willd growing in Egypt. Herba Hung 29 : 43-9. 1990-

Nashrin T et al, Inhibition of acetylcholine esterase & NADH oxidase by Acacia farnesiana. Panacea J Pharm & Pharmacol Sci 2012;1:6-8.

de la Steve C et al, Acute toxicity & decreased peristalsis in mice caused by Taxodium mucronatum & Acacia farnesiana extracts. Rev Latino-am, 2012;40(1):19-25

Garcia Santos et al, Extracts of Acacia farnesiana & Artemisia ludoviciana inhibit growth, enterotoxin production & adhesion of Vibrio cholerae, World J of Microbiol & Biotechnol, 22:669-74, 2006-Abstract: Extracts of 32 medicinal plants commonly used in Mexico were evaluated for their effects on the growth of Vibrio cholerae strains O1 & O139. Of these, the ethanolic extracts of Acacia farnesiana & Artemisia ludoviciana effectively inhibited bacterial growth. The effects of these plant extracts on enterotoxin production and adhesion of V. cholerae to Chinese hamster ovary (CHO) cells were …

Salfarina R et al, Antioxidant, antimicrobial & cytotoxicity activities of Acacia farnesiana (L.) Willd.Leaves ethanolic extract. Pharmacogn J, 2011;3(23):50-8.

Abrantes VE et al. Molecular modeling of lectin-like protein from Acacia farnesiana reveals a possible anti-inflammatory mechanism in carrageenan-induced inflammation. BioMed Res Int;2013:253-483.

Delgadillo Puga et al, Antioxidant activity & protection against oxidative-induced damage of Acacia shaffneri  & Acacia farnesiana pods extracts: in vitro & in vivo assays BMC Comp & Alter Med,2015;15:435-DOI: 10.1186/s12906-015-0959-y-Abstract: Main goal of the present study was to determine the antioxidant activity and protection against oxidative-induced damage of Acacia shaffneri (AS) and Acacia farnesiana (AF) pods extracts. Methods :To evaluated antioxidant activity and radical scavenging capacity of AS &  AF extracts, two experiments were performed: 1) pods extracts were challenged a…

Busineni JG et al, ANTI ULCER ACTIVITY OF ACACIA FARNESIANA (L.) (AROMA) A LESSER-KNOWN FOLK -MEDICINAL PLANT, Research-gate, 2013-Abstract: To determine the pharmacological activity relevant to ulcer healing of Acacia farnesiana (aroma) leaf, a folk medicine used in the treatment of Ulcer. Materials & Methods: MEAF extract was done by using soxhelet apparatus & was further subjected to screening of the qualitative analysis of phyto chemicals. Consequently the Methanolic extract of leaf was tested against ulcer induced rats. Results: The methanol extract of leaf (200mg/Kg) has shown greater…

Bino-Kingsley R et al, Anti-Diabetes Activity of Acacia farnesiana (L.) Willd In Alloxan Diabetic Rats, Inter J of PharmTech Res,.5 (1) :112-8, 2013-Abstract:The aim of the study was to scientifically validate traditional anti-diabetic claim of Acacia farnesiana & to determine its utility as a potential therapeutic agent. An active fraction from aqueous extract was obtained by alcohol precipitation method & anti-hyperglycemic activity was evaluated in normal glucose loaded rats. Anti-diabetes activity of the fraction was evaluated in alloxan-induced diabetic rats & short term toxicity evalu…

Maldonado-Magaña A et al, Lead bioaccumulation in Acacia farnesiana and its effect on lipid peroxidation and glutathione production,Plant Soil (2011) 339:377–389 DOI 10.1007/s11104-010-0589-6-

Mattana CM et al, Antibacterial and cytotoxic activities of Acacia aroma extracts,

Singh TT et al, Plants used in the treatment of piles by the scheduled caste community of Andro village in Imphal East District, Manipur (India), J of Plant Sci, 2014; 2(3): 113-9-doi: 10.11648/j.jps.20140203.13-

Alcantara-Martinez N et al, Tolerance, arsenic uptake, & oxidative stress in Acacia farnesiana under arsenate-stress Inter J of Phytoremediation, 2016; 18(7)-

Srikanth M et al, Evaluation of In Vitro Anthelmintic Activity of Acacia farnesiana

Shen LA et al. Acasiane A & B & farnesirane A & B, diterpene derivatives from the roots of Acacia farnesiana. Plant Med 2009;75(3):256-61.

Hernandez-Garcia E et al, Chemical composition of Acacia farnesiana (L) wild fruits & its activity against Mycobacterium tuberculosis & dysentery bacteria, J of Ethnopharmacol, 230:74-80, 2019-Abstract: Acacia farnesiana is used in Mexican traditional medicine to treat dysentery & tuberculosis & therefore could have bioactive compounds that may explain its traditional use. Aims of the study: i) To isolate & characterize the compounds from the hexanic, chloroformic & methanolic extracts; ii) to identify the volatile compounds from methylated hexanic & chloroformic extracts using GC-FID & GC-…

Sánchez E et al, Extracts of Edible & Medicinal Plants Damage Membranes of Vibrio cholerae, Appl. Environ. Microbiol., 2010, 76(20) :6888-94-