Acacia nilotica (Akasia-Kayenn’) : medicinal properties in alcoholic extraction

Singh BN et al, Potential chemoprevention of N-Nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. Chem-Biol. Interact., 181: 20-8. 2009b-Abstract: Chemopreventive potential of Acacia nilotica bark extract (ANBE) against single intraperitoneal injection of N-nitrosodiethylamine (NDEA, 200mg/kg) followed by weekly subcutaneous injections of carbon tetrachloride (CCl (4), 3 ml/kg) for 6 weeks induced hepatocellular carcinoma (HCC) in rats was studied. At 45 days after administration of NDEA, 100 & 200mg/kg of ANBE were administered orally once daily fo…

-Singh R et al, Umbelliferone – An antioxidant isolated from Acacia nilotica (L.) Willd. Ex. Del. Food Chem., 120: 825-830. 2010b,

-Singh R et al, Anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) Willd. Ex. Del. Toxicol. Vitro, 22(8): 19. 2008a,

Singh BN et al, Antioxidant & anti-quorum sensing activities of green pod of Acacia nilotica L. Food Chem. Toxicol., 47: 778-786. 2009a,

Abeer NHA et al, Antimicrobial Activity of Acacia Nilotica Extracts Against Some Bacteria Isolated from Clinical Specimens; 2007. 25. 28&org=10 :1-3,

Singh R et al, Phytochemical analysis & antibacterial activity of Acacia nilotica (L.) leaves against pathogenic bacteria. Inter J of Green Pharm, 10 (2):104. 2016,

Mitra S et al, Antioxidant activity of ethyl acetate soluble fraction of Acacia arabica bark in rats. Indian J. Pharmacol., 39(1): 33-38. 2007,

Ranjan S et al, Acacia nilotica leaf improves insulin resistance & hyperglycemia associated acute hepatic injury & nephrotoxicity by improving systemic antioxidant status in diabetic mice, J Ethnopharmacol, 210:275-86, 2017-Abstract: the objective of the study was to evaluate the ethnomedicinal claim of A. nilotica leaf (ANL) extract for its efficiency in ameliorating diabetic complications. Materials & methods: ANL was orally administrated (50 & 200mg/kg) to alloxanized mice (blood glucose > 200mg/dL) for 20d. Parameters of glucose metabolism, hepatotoxicity, hyperlipidemia & nephrotoxicit…

Banso A et al: Phytochemical & Antimicrobial Investigation of Bark Extract of Acacia Nilotica. J of Med Plants Res. 3(2) : 82- 88,

Fadh il Y et al, Assessment of a novel activity of Acacia nilotica leaf extract for chondrogenesis induction of Mesenchymal stem cells for dental applications, Phytomed Plus, 1:4, 2021-Abstract:.The current study was carried out to investigate the herbal-based chondrogenesis inducing ability of leaves extract of Acacia Nilotica in Mesenchymal stem cells (MSCs). Purpose: To investigate the ability of AN leaves extract in chondrogenesis induction from Mesenchymal stem cells Study design: The experimental were designed according to the completely randomized design Methods: Different concentrat…

Baravkar AA et al, Pharmaceutical biological evaluation of formulated cream of

Kaur K et al, In vitro bioactivity-guided fractionation & characterization of polyphenolic inhibitory fractions from Acacia nilotica (L.) Willd. ex Del. J. Ethnopharmacol., 99: 353-630, 2005,

Baravkar AA et al, Pharmaceutical biological evaluation of formulated cream of methanolic extract of Acacia nilotica leaves. Res J Pharm. Technol, 1(4): 481-3. 2008,

Aulya NR et al, Effect of Aqueous & Ethanol Extract of Acacia nilotica L. Leaves on Seed Germination of Vigna radiata, Ind J Of Sci & Educ, 4:2, 2020-Abstract: This research aimed to tested the effect of extract on Vigna radiata germination. Tested the effect of crude extract of A. nilotica leaves on germination was conducted experimentally using Factorial Completely Randomized Design (FCRD). The first fact or was the type of crude extract & the second factor was levels of extract concentration. The result showed that the application of aqueous & ethanol extract enhanced all parameters of V…

Riaz S et al, Antibacterial & Cytotoxic Activities of Acacia nilotica Lam (Mimosaceae) Methanol Extracts Against Extended Spectrum Beta-Lactamase Producing Escherichia coli & Klebsiella Species. Trop J of Pharmaceut Res, 10 (6): 785-91, 2011-

Hossain H et al, Evaluation of Antidiarrhoeal Potential of the Ethanolic Extract of Three Bangladeshi Medicinal Plants, Int J Pharm Phytopharmacol Res, 1(6) :371-4, 2012.-Abstract: The present study was designed to investigate the antidiarrhoeal activity as well as phytochemical screening of ethanolic extract of three Bangladeshi medicinal plants namely Diospyros blancoi (leaf), Acacia nilotica(bark) & Hibiscus sabdariffa (Seed & calyxes). The ethanol extracts at graded doses (250 & 500 mg/kg body weight) were investigated for antidiarrhoeal activity in acetic acid induced writhing model in…

Solomon G.O.W et al, in vitro antimicrobial & phytochemical activities of Acacia nilotica leaf extract. J of Med Plants Res, 4(12), pp. 1232-1234. DOI: 10.5897/JMPR09.136, 2010,

Bilal-Hussein M et al, hypocholesterolemic Effect of Acacia & Citrus Honeys on Cholesterol Induced Sprague Dawley Rats, Sains Malaysiana, 50(10) :3095-106, 2021-Abstract: Current project was designed to discover the nutraceutical worth of natural unifloral honeys from Acacia nilotica (Desi Kikar) and Citrus limetta (Mosambi) against hypercholesterolemia. Initially both honey varieties were analyzed for TPC and TFC, followed by DPPH & FRAP assays. Afterwards, honey drinks were prepared using different concentrations of Acacia & Citrus honeys (10:20:30 g/250 mL water) & were tested in experim…

Diab KA et al, Evaluation of the cytotoxic, anticancer, & genotoxic activities of Acacia nilotica flowers & their effects on N-methyl-N-nitrosourea-induced genotoxicity in mice, Mol Biol Rep, 49(9):8439-48, 2022-Abstract: In this study, two main research objectives were examined: (1) the cytotoxic & anticancer activities of the aqueous methanol extract from Acacia nilotica flowers on three human cancer cells, namely lung A549, breast MCF-7, & leukemia THP-1 cells, & (2) the genotoxic effects of AN extract & its influence on DNA damage induced by N-methyl-N-nitrosourea (MNU) in mice. Methods…

-Amos S et al, The pharmacological effects of an aqueous extract from Acacia nilotica seeds. Phytother. Res., 13: 683-5.1999,

Kabbashi AS et al, ANTIGIARIDIAL ACTIVITY & CYTOTOXICITY OF ETHANOLIC BARK EXTRACT OF ACACIA NILOTICA (L), Med J of BioSci, 1:4, 2016-Abstract:  Acacia nilotica was used to treat different ailments for instance cold, congestion, fever, gallbladder, hemorrhage, hemorrhoids, leucorrhoea, ophthalmic, sclerosis, small pox, intestinal pains & acute diarrhea. Other preparations are used for gargle, toothache, ophthalmic & syphilitic ulcers. Human parasitic infections still represent a challenging public health problem worldwide, especially in tropical & subtropical regions. Giardiasis is the most…

Thiagarajan K et al, Antiproliferative effect of Acacia nilotica (L.) leaf extract rich in ethyl gallate against human carcinoma cell line KB-Abstract: The objective of this study is to analyze the antiproliferative activity of Acacia nilotica leaf ethanolic extract against cancer KB cells & to determine the mode of cancer cytotoxicity. Materials & methods: In this study, high-performance liquid chromatography & liquid chromatography-mass spectrometry analysis was done to confirm the presence of ethyl gallate as a major bioactive phenolic in the leaf ethanolic extract of A. nilotica, furthe…

Singh BN et al, Potential chemoprevention of N-Nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. Chem-Biol. Interact., 181: 20-8. 2009b-Abstract: Chemopreventive potential of Acacia nilotica bark extract (ANBE) against single intraperitoneal injection of N-nitrosodiethylamine (NDEA, 200mg/kg) followed by weekly subcutaneous injections of carbon tetrachloride (CCl (4), 3 ml/kg) for 6 weeks induced hepatocellular carcinoma (HCC) in rats was studied. At 45 days after administration of NDEA, 100 & 200mg/kg of ANBE were administered orally once daily fo…

Mohan S et al, In vitro protection of biological macromolecules against oxidative stress & n vivo toxicity evaluation of Acacia nilotica (L.) & ethyl gallate in rats-BMC Comp & Alter Med, 14:257, 2014-Abstract: Acacia nilotica is widely distributed in Asia, Africa, Australia & Kenya. The plant is traditionally used to treat mouth, ear and bone cancer. However, reports on Acacia nilotica regarding its toxicity profile is limited. Hence in this study, we investigated the antioxidant capacity & acute toxicity of ethyl gallate, a phenolic antioxidant presents in the AN leaf extract. Methods: Th…

Shittu GA, in vitro antimicrobial & phytochemical activities of Acacia nilotica leaf extract. J. Med. Plants Res., 4(12): 1232-4. 2010,

Sultana B et al, Antioxidant activity of phenolic components present in barks of Azadirachta indica, Terminalia arjuna, Acacia nilotica & Eugenia jambolana Lam. trees. Food Chem., 104: 1106-14, 2007-Abstract: Barks extracts of four different trees (Azadirachta indica, Terminalia arjuna, Acacia nilotica, & Eugenia jambolana in three different solvents 80% methanol, 80% ethanol, & 80% acetone (solvent: water, 80:20 v/v) were evaluated for their antioxidant activity, total phenolic (TP), & total flavonoids (TF) contents. Antioxidant activity (AA) was determined by measuring reducing power, i…

Ali NM et al, Synthesis of Cinnamomum zeylanicum & Acacia nilotica Extracts and Their Antibacterial Activity against Staphylococcus aureus & Streptococcus pyogenes, J of Oleo Sci, 71(6) :845-52, 2022-Abstract: Different plants are used medically and these therapeutic plants have great importance for healing contagious wounds. This herbal treatment is actually also a substitute of different antibiotics & having less side effects on intestinal systems of animals. The foremost concern of this study was to observe the antibacterial activity of Cinnamum zeylanicum a Acacia nilotica. Pathogenic b…

-Singh R et al, Umbelliferone – An antioxidant isolated from Acacia nilotica (L.) Willd. Ex. Del. Food Chem., 120: 825-830. 2010b,

-Singh R et al, Anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) Willd. Ex. Del. Toxicol. Vitro, 22(8): 19. 2008a,

Omara EA et al, Therapeutic effect of Acacia Nilotica pods extract on streptozotocin induced diabetic nephropathy in rat. Phytomed. 2012; 19:1059–67-Abstract :The aim of the present study was to examine the effect of aqueous methanol extract (150 & 300 mg/kg body weight) of Acacia nilotica pods in streptozotocin-induced diabetic rats for 60 days, & its biochemical, histopathological & histochemical study in the kidney tissues. Diabetic rats exhibited hyperglycemia, elevated of serum urea & creatinine. Significant increase in lipid peroxidation (LPO), superoxide dismutase (SOD) & reduced glu…

Dahab MM et al, In vitro Antitrichomonal Activity of Acacia nilotica L different extracts. Inter j of Nat Prod & Pharmaceut Sci. 1(1): 10-14.2010-

Abd'Quadri-Abojukoro AN et al, Phytochemical composition & cytotoxicity of ethanolic extracts of some selected plants, J of Applied Animal Res, 50:1, 2022-Abstract: This study determines the phytochemical contents of selected medicinal plant extracts quantitatively using spectro-photometry & to evaluate their safety on mammalian cells in vitro using tetrazolium-based colorimetric cytotoxicity assay. Twenty-two ethanolic plant extracts were assessed, & the result showed that Psidium guajava leaf had the highest concentration of alkaloids (219.06±11.50mg/g dry-weight (dw)). In contrast, Acaci…

Oluwale OP et al, Antituberculosis Activity of Bioactive Compounds from Fruit Extract of Acacia nilotica, Microbiol, 2020-Abstract: Three antituberculosis bio active compounds viz garlic acid, methyl garlic & catechin were isolated from fruit extract of Acacia nilotica by high throughput chromatography techniques-column chromatography, high performance liquid chromatography & Liquid chromatography-Mass spectra & characterized by Nuclear magnetic resonance. The isolated compounds tested against Mycobacterium tuberculosis by broth microdilution method were significantly active at 62.5, 31.25 …

Shekar Chandra BR et al, antimicrobial efficacy of Acacia nilotica, Murraya koenigii (L.) Sprengel, Eucalyptus hybrid, Psidium guajava extracts & their combination on Streptococcus mutans & Lactobacillus acidophilus Dental Res J, 12(3-;168, 2016-Abstract: The aim of this in vitro study was to assess antimicrobial efficacy of Acacia nilotica, Murraya koenigii (L.) Sprengel, Eucalyptus hybrid, Psidium guajava extracts, & their combination on Streptococcus mutans & Lactobacillus acidophilus. Materials & methods: The branches of four plants were collected, identified, & authenticated by a taxon…

Singh BN et al, Antioxidant & anti-quorum sensing activities of green pod of Acacia nilotica L. Food Chem. Toxicol., 47: 778-786. 2009a,

Subahaswaraj P et al, Determination of antioxidant potential of Acacia nilotica leaf extract in oxidative stress response system of Saccharomyces cerevisiae, J Sci Food Agric, 97(15):5247-5253. doi: 10.1002/jsfa.8409. Epub 2017-Abstract: The present study aimed to determine the antioxidant efficacy of crude Acacia nilotica extract in the oxidative stress response system of Saccharomyces cerevisiae as a model organism. Results: A nilotica showed significant antioxidant activity, with IC50 values of 75.157 & 159.57 µg mL-1 for 2,2-diphenyl-1-picrylhydrazyl radical & hydroxyl radical scavengin…

Ali A et al, Acacia nilotica: A plant of multipurpose medicinal uses, J of Med Plants Res, 6(9):1492-6, 2012-Abstract: Acacia nilotica Lam (Mimosaceae) indigenously known as 'Babul' or 'Kikar' is a proverbial, medium sized tree and is broadly scattered in tropical and subtropical countries. It has an inspiring range of medicinal uses with potential anti-oxidant activity. This plant contributes a number of groups among which are alkaloids, volatile essential oils, phenols and phenolic glycosides, resins, oleosins, steroids, tannins and terpenes. A. nilotica is a medicinal plant acknowledged …

El-Tahir A et al, Antiplasmodial activity of selected sudanese medicinal plants with emphasis on Acacia nilotica. Phytother. Res., 13: 474-8, 1999,

Lall N et al, Antityrosinase & anti-acne potential of plants traditionally used in the Jongilanga community in Mpumalang, South Afr J of Botany, 123, 2019-Abstract: The purpose of the present study was to examine the antityrosinase, anti-acne, antioxidant & cytotoxic potential of 25 ethanolic extracts from 16 different plant families which were collected in the Jongilanga community in the Mpumalanga province. The tyrosinase inhibitory activity was evaluated using the mushroom tyrosinase enzyme to determine potential plant extracts that could treat skin hyperpigmentation. Six of the plant ex…

Kalaivani T et al, Free radical scavenging, cytotoxic, & hemolytic activities of an active antioxidant compound ethyl gallate from leaves of Acacia nilotica (L.) Wild. Ex. Delile subsp. indica (Benth.) Brenan, J Food Sci, 76(6): T144-9, 2011-Abstract: In the present study, free radical scavenging, cytotoxic, & hemolytic activities of the polyphenolic compound ethyl gallate isolated from ethanol extract of Acacia nilotica leaves were determined. The free radical-scavenging activities of the ethyl gallate were demonstrated in several in vitro assays in order to evaluate the possible antioxida…

El-Jana SM et al, Ability Test of Acacia Nilotica Leaves & Extract as Water Disinfectants, Knowledge, Djakarta, Abstract: The fulfillment of clean water that meets bacteriological requirements for urban areas is increasingly difficult due to the high contamination of groundwater by microbes. The use of chemical compounds as disinfectants always produces long-term side effects, it is necessary to develop plants that can be used as disinfectants. Acacia nilotica has the ability to kill aerobic & coliform bacteria so that it has the potential to disinfect water. The study aimed to examine the …

Muddathir AM et al, In vitro activities of Acacia nilotica (L.) Delile bark fractions against Oral Bacteria, Glucosyltransferase & as antioxidant, BMC Comp Alter Med, 20(1): 360, 2020-Abstract: Acacia nilotica was commonly known in Sudan as Garad or Sunt has a wide range of medicinal uses. In the present study, antibacterial activity of oral bacteria (Streptococcus sobrinus and Porphyromonas gingivalis), inhibitory activity against glucosyltransferase (GTF) enzyme and antioxidant activity were assayed for methanolic crude extract of A. nilotica bark and its fractions. Methods: Methanolic cr…

Okoro SO et al, PHYTOCHEMICAL SCREENING, ANTIBACTERIAL & TOXICOLOGICAL ACTIVITIES OF ACACIA NILOTICA EXTRACTS, Bajopas, 7:1, 2014-Abstract: The phytochemical screening, antibacterial and toxicological activities of extracts of the leaves, stem bark and roots of Acacia nilotica were investigated. The phytochemical analyses according to standard screening tests using conventional protocols revealed the presence of tannins & sterols in the leaves stem barks and roots of the plant. Alkaloids were detected only in the leaves. Glycosides, saponins, resins and flavonoids were not detected in the p…

Kalaivani T et al, Free radical scavenging activity from leaves of Acacia nilotica (L.) Wil. ex Delile, an Indian medicinal tree. Food Chem. Toxicol., 48: 298-305, 2010a,

Siegler D. S. Phytochemistry of Acacia-sensu lato. Biochem Systematics & Ecology. 31: 845-873, 2003,

Meena PD et al, Anticancer & antimutagenic properties of Acacia nilotica (Linn.) on 7, 12-dimethylbenz(a) anthracene-induced skin papillomagenesis in Swiss albino mice. Asian Pac. J. Can. Prev., 7: 627-632. 2006-Abstract: We report the chemopreventive activity of Acacia nilotica gum, flower & leaf aqueous extracts, on 7,12-dimethylbenz(a)anthracene (DMBA) induced skin papillomagenesis in male Swiss albino mice. Animals were divided into following groups: Group I (Controls) given DMBA & croton oil, with no extract; Group II (treatment) animals treated with Acacia nilotica gum (Group II-a) (8…

Jigam AA et al Polygalloyltannin isolated from the roots of Acacia nilotica Del. (Leguminoseae) is effective against Plasmodium berghei in mice. J. Med. Plants Res., 4(12): 1169-75. 2010,

Sharma K et al, Studies on Antimicrobial & Immunomodulatory Effects of Hot Aqueous Extract of Acacia nilotica L. Leaves against Common Veterinary Pathogens, Vet Med Inter, 2014-Abstract: Acacia nilotica is a plant species that is almost ubiquitously found in different parts of the world. Various preparations of it have been advocated in folk medicine for the treatment of tuberculosis, leprosy, smallpox, dysentery, cough, ophthalmia, toothache, skin cancer as astringent, antispasmodic, & aphrodisiac since immemorial times. The present study investigates the antibacterial, antifungal, antivir…

Crowch EM et al, Kinetics of acetylcholinesterase inhibitory activities of aqueous extracts of acacia Nilotica (L) & Rhamnus prinoides. Afr. J. Pharm. Pharmacol., 3(10): 469-75.

Mehmood K et al, Phytotoxic potential of bark extracts of Acacia nilotica & Syzygium cumini against Parthenium hysterophorus, PAK J OF BOTANY, 43 :6, 3007-Abstract: Effect of aqueous & n-hexane bark extracts of allelopathic tree species viz., Acacia nilotica & Syzygium cumini (L.) Skeels was studied on germination & seedling growth of Parthenium hysterophorus L. In laboratory trials, all the concentrations of aqueous extract of both the test plants increased seed germination of target weed while by employing n-hexane concentrations of A. nilotica the number of germinated seeds remained the …

Gilani AH et al, Studies on antihypertensive & antispasmodic activities of methanol extract of Acacia nilotica pods. Phytother. Res., 13: 665-9. 1999,

Lompo-Ouedraogo Z et al, Effect of aqueous extract of Acacia nilotica ssp adansonii on milk production & prolactin release in the rat. J. Endocrinol., 182: 257-66. 2004,

Sadiq MB et al, In vitro antioxidant & antimalarial activities of leaves, pods & bark extracts of Acacia nilotica (L.) Del, BMC Comp Alter Med, 17(1):372, 2017-Abstract: There is an urgent need to develop novel & chemically diverse antimalarial drugs. This study aimed at evaluating the antimalarial & antioxidant potentials of Acacia nilotica plant extracts. Methods: The antioxidant activities of leaves, pods & bark extracts were determined by standard antioxidant assays; reducing power capacity, % lipid peroxidation inhibition & ferric reducing antioxidant power assay. The antimalarial acti…

Elamary RB et al, Efficacy of Acacia nilotica aqueous extract in treating biofilm-forming & multidrug resistant uropathogens isolated from patients with UTI syndrome, 10(1):11125. 2020-doi: 10.1038/s41598-020-67732-w.-Abstract: Escherichia coli is the dominant bacterial cause of UTI among the uropathogens in both developed & developing countries. This study is to investigate the effect of Acacia nilotica aqueous extract on the survival & biofilm of isolated pathogens to reduce UTIs diseases. A total of 170 urine samples were collected from Luxor general hospital & private medical analysis l…

Del WE, In-vitro evaluation of peroxyl radical scavenging capacity of water extract / fractions of Acacia nilotica (L.). Afr. J. Biotechnol., 8(7): 1270-2, 2009,

El Gendy AED et al, Antiviral Potentialities of Chemical Characterized Essential Oils of Acacia nilotica Bark & Fruits against Hepatitis A & Herpes Simplex Viruses: In Vitro, In Silico, & Molecular Dynamics Studies, Plants Basel, 10(21):2, 2022-Abstract:Acacia nilotica (synonym: Vachellia nilotica (L.) P.J.H.Hurter & Mabb.) is considered an important plant of the family Fabaceae that is used in traditional medicine in many countries all over the world. In this work, the antiviral potentialities of the chemically characterized essential oils (EOs) obtained from the bark & fruits of AC were a…

Sundaraj S et al, γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest & apoptosis through c-Myc suppression in MCF-7 & A549 cells, J Ethnopharmacol, 141(3):803-9, 2012-Abstract: Acacia nilotica is widely distributed in Asia. In India, it occupies an important place in the indigenous system of medicine against anti-inflammatory, antioxidant, cancers, and/or tumors. Aim of the study: The purpose of this study is to investigate the inhibitory effect of Acacia nilotica leaves extract & γ-Sitosterol on cell proliferation, the apoptotic effect & cell cycle arrest in breast & lung …