Acanthospermum hispidum (Ox-head) : medicinal properties in alcoholic extraction
Acanthospermum hispidum (Ox-head, Zombie-hair, Tèt-bèf, Chivé-Zonbi, tète-à-bœuf, Cheveux-à-Zombi) — family Astéracées.
Scientific synonyms : Acanthospermum humile var. Hispidum -(DC)-Kunth.
Recognised external sources linked to this monograph: TRAMIL.
This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 6 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 21 scientific references for this species (full detail in the application).
Therapeutic indications in alcoholic extraction:
Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).
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Bacterial infection: Bacillus subtilis, Klebsiella pneumoniae, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to ADUE F (2011)
Excerpt The extract demonstrated antibacterial activity against Staphylococcus aureus, Klebsiella pneumoniae, Bacillus subtilis, Salmonella typhi, Proteus vulgaris & Pseudomonas aeruginosa with MICs ranging between 11 and 53 mg/ml. The effect of the sub-inhibitory concentrations of Acanthospermum hispidum extract on the activities of amoxicillin and ciprofloxacin was assessed by the Kirby-Bauer disc diffusion method.
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According to GOMATHI V (2013)
Excerpt The ethanolic extract of whole plant of Acanthospermum hispidum DC exhibited significant antioxidant activity by total antioxidant activity assay, nitric acid free radical scavenging activity assay, reducing power assay and hydrogen peroxide free radical scavenging assay. The present study was carried out to preliminary phytochemical and antioxidant activity of whole plant of Acanthospermum hispidum DC.
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According to ADUE F (2011)
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Cancer: adjuvant treatment for lymphatic carcinoma
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Deepa N (2007)
Excerpt (2007) investigated the antitumor activity of 50% aqueous ethanol extract of Acanthospermum hispidum DC against Dalton’s ascites Lymphoma in mice. Thus, it is suggested that Acanthospermum hispidum DC appears promising for the development of Phytomedicine for the treatment of cancer.
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According to GOMATHI V (2013)
Excerpt The ethanolic extract of whole plant of Acanthospermum hispidum DC exhibited significant antioxidant activity by total antioxidant activity assay, nitric acid free radical scavenging activity assay, reducing power assay and hydrogen peroxide free radical scavenging assay. The present study was carried out to preliminary phytochemical and antioxidant activity of whole plant of Acanthospermum hispidum DC.
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According to ADUE F (2011)
Excerpt The effect of the sub-inhibitory concentrations of Acanthospermum hispidum extract on the activities of amoxicillin and ciprofloxacin was assessed by the Kirby-Bauer disc diffusion method. hispidum appears to contain Phytoconstituents that may be useful adjuvant for antibiotic formulations.
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According to Deepa N (2007)
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Fungal infection: candidiasis
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Chakraborty AK (2012)
Excerpt A scrutiny of the literature revealed some notable pharmacological activities of the drug like antimicrobial, antifungal, antiviral, Anthelmintic, immunomodulator, Abortifacient, Antitrypanosomal and Antileishmanial. The present review is an attempt to highlight the various ethnobotanical and traditional uses as well as the various phytochemical and pharmacological reports on Acanthospermum Hispidum.
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According to Arena ME (2011)
Excerpt Arena ME et al: In vivo & in vitro Antibacterial activity of acanthospermal, B, a sesquiterpene lactone isolated from Acanthospermum hispidum.
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According to Theresa IE (2011)
Excerpt Theresa IE et al: Two Flavones from Acanthospermum Hispidum DC & their Antibacterial Activity.
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According to Summerfield A (1997)
Excerpt Summerfield A et al, Antiviral activity of an extract from leaves of the tropical plant Acanthospermum hispidum.
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According to Fleischera TC (2003)
Excerpt The ethanolic extracts of the leaves and flowering tops of Acanthospermum hispidum showed varying degrees of activity against a wide range of pathogenic bacteria.
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According to Chakraborty AK (2012)
Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.
Evolution of this plant record
Under the CTA · public change history
+1 indication · −1 indication · +1 synergy
Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Full bibliographic texts for new, corrected, or removed references expand below.
First public publication
+21 references
Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Full bibliographic texts for new, corrected, or removed references expand below.
+21 references — show text
Herz W et al: Acanthospermal A and Acanthospermum B, two new melampolides from Acanthospermum hispidum species. J Org Chem. 1975;40: 3486-91.
AddedMathur SB et al: Isolation of triacontane, N-butyl eicosante & N-heptacosanol from Acanthospermum hispidum. Phytochemistry. 1976; 15: 2026.
AddedSanon S et al: Antiplasmodial activity of alkaloid extracts from Pavetta crassipes (K. Schum) & Acanthospermum hispidum (DC), two plants used in Traditional medicine in Burkina. Faso. Parasitol Res. 2003; 90:314-7.
AddedGANFON H et al, Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum Hispidum DC (Asteraceae), J of Ethnopharmacol, 11 :411-7, 2012.
AddedTheresa IE et al: Two Flavones from Acanthospermum Hispidum DC & their Antibacterial Activity. Inter J of Organic Chem. 2011; 1(3):226-33.
AddedArena ME et al: In vivo & in vitro Antibacterial activity of acanthospermal, B, a sesquiterpene lactone isolated from Acanthospermum hispidum. Phytother Research; 2011 25(4): 597–602.
AddedCartagena E et al, Germacranolides & a new type of guaianolide from Acanthospermum hispidum. J Nat Prod 63: 1323-8.2000,
AddedLemonica IP et al, Abortive & teratogenic effect of Acanthospermum hispidum DC & Cajanus cajan (L) Millps in pregnant rats J of Ethnopharm 1994; 43 :1:39-44.-Abstract: Extracts of Acanthospermum hispidum and Cajanus cajan have been used by Brazilian people in an attempt to produce abortion. In order to evaluate the possible abortive and/or teratogenic effect of these plant extracts, female Wistar rats were treated with the aqueous extract (infusion, proportion C. cajan and A. hispidum 1:1.3). Doses of 0, 150, 300 & 600 mg/kg were daily administered by gavage during the organogenic period. T…
AddedEDEWOR IT et al, Effects Of Oral Administration Of Ethanolic Leaf Extract Of Acanthospermum Hispidum Dc On Carbon Tetrachloride Induced Acute Liver Injury In Rats, Biochem, 1(2), 2007-Abstract: -The effects of administering the ethanolic leaf extract of Acanthospermum hispidum dc on patients of hepatitis were studied on acute hepatitis induced by carbon tetrachloride (20% CCl4/olive oïl, 1.5 ml/kg, p.o) in rats. These effects were monitored by estimating the serum transaminases levels and the histopathological changes in the livers of experimental rats. The pretreatment of the animals with …
AddedDeepa N et al: Antitumor Activity of Acanthospermum hispidum DC on Dalton Ascites Lymphoma in Mice. Natural Prod Sci. 2007; 13(3): 234-40.-Abstract: N. Deepa et al. (2007) investigated the antitumor activity of 50% aqueous ethanol extract of Acanthospermum hispidum DC against Dalton’s ascites Lymphoma in mice. The extracts were prepared by cold maceration with 50% aqueous ethanol and evaporated in vacuum to dry. (Yield: 50%aqueous ethanol -8.62% w/w). The extract was suspended in water with tween 20 and used for the study. The 50% aqueous ethanol extract (300 mg/kg p.o) was administered to …
AddedADUE F et al, the effects of Acanthospermum hispidum extract on the antibacterial activity of Amoxicillin and Ciprofloxacin, Hygeia, J for Drugs & Med, 3(1), 58-63, 2011-Abstract: The effect of the sub-inhibitory concentrations of Acanthospermum hispidum extract on the activities of amoxicillin and ciprofloxacin was assessed by the Kirby-Bauer disc diffusion method. The extract demonstrated antibacterial activity against Staphylococcus aureus, Klebsiella pneumoniae, Bacillus subtilis, Salmonella typhi, Proteus vulgaris & Pseudomonas aeruginosa with MICs ranging between 11 and 53 mg/ml. A 5 …
AddedHare-Krishna R et al, Preliminary Phytochemical investigation and Anthelmintic activity of Acanthospermum hispidum DC. Journal of Pharmaceut Sci & Technology. 2010; 2 (5): 217-21.
AddedCOMPARITIVE STUDY OF HEPATOPROTECTIVE ACTIVITY OF ACANTHOSPERMUM HISPIDUM PLANT EXTRACT AND HERBAL NIOSOMAL SUSPENSION AGAINST ANTI-TUBERCULAR DRUG INDUCED HEPATOTOXICITY IN RATS, Asian J of Pharm & clinical Res, 8(5), 2015 -ABSTRACT: Compare the hepatoprotective activity of Acanthospermum hispidum ethanolic extract (AHEE) & herbal niosomal suspension (HNS) against hepatotoxicity. Methods: AHEE and HNS were investigated against hepatotoxicity produced by administering a combination of four Antitubercular drugs (ATDs) isoniazid (27 mg/kg), rifampin (40 mg/kg), Pyrazinamide (66 mg/kg), and et…
AddedKPEMISSI M et al, Hepatoprotective & antioxidant effects of Acanthospermum hispidum (DC) leaves on carbon tetrachloride-induced acute liver damage in rat, https://www.researchgate.net/ Publication/293800399.
AddedChakraborty AK et al, Phytopharmacological review on Acanthospermum Hispidum, J of Applied Pharm Sci 02 (01); 2012: 144-8-ABSTRACT: Acanthospermum Hispidum (Family: Asteraceae) is an annual plant which is native to tropical America. This plant is cited as a weed in cotton culture in Brazil, and it is also used as a medicinal plant. The leaves and flowering tops of the plant have antimicrobial activity. The ethanolic extract of leaves and flowering tops gives activities against wide range of pathogenic bacteria. Crushed herb is use in the form of the paste to treat the skin aliments and leaf…
AddedEvani L et al: Acanthospermum hispidum DC (Asteraceae): perspectives for a phytotherapeutic Product. Rev. Bras. Farmacogn. 2008; 18.
AddedNair AGR et al: Polyphenolic compounds from leaves of Acanthospermum hispidum. Fitoterapia. 1985; 56: 249-50.
AddedFleischera TC et al: Antimicrobial activity of the leaves and flowering tops of Acanthospermum hispidum. Fitoterapia. 2003; 74: 130–2.-Abstract: The ethanolic extracts of the leaves and flowering tops of Acanthospermum hispidum showed varying degrees of activity against a wide range of pathogenic bacteria. The activity resided mostly in the polar fractions of the alcoholic extract, being only slight in the non-polar fractions. No activity was observed for the aqueous extract of the fresh plant material.
AddedSummerfield A et al: Interleukin-2 dependent sélective activation of porcine γδ T lymphocytes by an extract from the leaves of Acanthospermum hispidum. Inter J of Immunopharmacol.1988; 20: 85-98.
AddedSummerfield A et al, Antiviral activity of an extract from leaves of the tropical plant Acanthospermum hispidum. Antiviral Res. 1997;36: 55–62.
AddedGOMATHI V et al, Preliminary Phytochemical and In-Vitro Antioxidant Activity of the Whole Plant of Acanthospermum Hispidum Dc, Inter J of Med & Pharm, 1(1), 2013-Abstract: A hispidum DC is a branched herb up to 60cm Tall. The stems of these plants are covered with bushy hairs and smaller glandular hairs. It is used for the treatment of jaundice, malaria, vomiting, cephalgias, headache, abdominal pain, convulsions, stomachache, constipation, eruptive fever, snake bite, epilepsy, blennorrhoea, Hepatobiliary disorders, malaria, microbial infection and viral infections. Acanthospermum hispidum …
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