Acanthus montanus (Zèb-dôwlis) : medicinal properties in alcoholic extraction
Acanthus montanus (Zèb-dôwlis, Golden-leaved herb, Herbe-à-dorlis) — family Acanthacées.
Scientific synonyms : Acanthus barleri – T. Anderson, Cellopsis Montana-Nees, Acanthus barleri-T Anderson.
This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 3 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 18 scientific references for this species (full detail in the application).
Therapeutic indications in alcoholic extraction:
Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).
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Type 1 diabetes mellitus
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Ojiako OA (2015)
Excerpt The present study ascertained the capacities of crude aqueous & ethanolic leaf extracts of Acanthus Montanus, Asystasia gangetica, Emilia coccinea & Hibiscus rosa sinensis, as well as their Combinatorial formulations to ameliorate hyperglycemia in Type I diabetic rats. Individual hyperglycemic rats (HyGR) received separate doses of either 20 mg/kg bw/24 h of A Montanus (ACMO), A gangetica (ASGA), E coccinea (EMCO) or H rosa sinensis (HIRO), as well as their Combinatorial formulations (AAEH) for 14 days.
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According to Ogundajo A (2016)
Excerpt The aim of this study was to determine the in-vitroanti-diabetic potentials of Acanthus montanus. montanus leaves with methanol & ethanol & subsequent evaluation of the extracts for possible hypoglycemic effect.
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According to Ukwe CV (2011)
Excerpt Hypoglycemic activity of Acanthus montanus, used locally in Nigeria to “cure” diabetes, was evaluated. Using normoglycemic & alloxanized (alloxan monohydrate 70 mg/kg IV body weight) rats, pre-treatment was done with 400 mg/kg of the extract & glibenclamide 10 mg/kg as reference drug orally.
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According to Matos P (2022)
Excerpt Aim of the review : To our knowledge, this document is the first comprehensive review study that provides information on the geographic distribution, botanical characteristics, ethnomedicinal uses, phytochemicals, & pharmacological activities of some Acanthus species to understand the correlation between traditional uses, phytochemical, & pharmacological activities, providing perspectives for future studies. Despite this, studies in animal models corroborate some of its uses in folk medicine, such as anticancer, antidiabetic, anti-inflammatory, & antinociceptive, which encourages the research on plants of this genus.
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According to Ojiako OA (2015)
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Liver disorders: - hepatitis, cirrhosis, fatty liver, normalisation of serum parameters
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Patric-Iwuanyanwu K C (2008)
Excerpt the hepatoprotective effects of aqueous & alcoholic extracts of stem & leaf of Acanthus montanus pre-treatment against carbon tetrachloride (CCl4,)-induced liver damage in wistar albino rats were investigated. Histopathological examinations in rats administered CCl4-alone showed severe hepatic damage to the liver.
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According to Omekannaya B (2023)
Excerpt The result indicates that the leaf extract of Acanthus montanus protected the liver against hepatotoxicity effect of paracetamol & also has shown to be safe foe human consumption. The study investigated the effects of methanol extract of Acanthus montanus leaves on liver function indices of paracetamol induced male albino rats.
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According to Matos P (2022)
Excerpt Aim of the review : To our knowledge, this document is the first comprehensive review study that provides information on the geographic distribution, botanical characteristics, ethnomedicinal uses, phytochemicals, & pharmacological activities of some Acanthus species to understand the correlation between traditional uses, phytochemical, & pharmacological activities, providing perspectives for future studies. Results : In traditional medicine, Acanthus species are mainly used for diseases of respiratory, nervous and reproductive system, gastrointestinal & urinary tract, and skin illness.
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According to Igwe OU (2014)
Excerpt The leaves of Acanthus montanus are used in traditional herbal practices in South Eastern Nigeria & in some other parts of West Africa for the treatment of gonorrhoea, syphilis, wounds & boils. Other uses of AM in herbal medicine include the treatment of hypertension, cardiac dysfunctions, hepatitis & heart diseases.
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According to Nana P (2008)
Excerpt Acanthus montanus is a plant used in Cameroon to treat pains & threatened abortion. However after delivery, these signs of growth retardation were seen before day 5 & henceforth, the treated pups regained all their parameters to normality.
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According to Patric-Iwuanyanwu K C (2008)
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Bacterial infection: Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Escherichia coli, Salmonella typhi and Proteus mirabilis
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Igwe OU (2014)
Excerpt The extract exhibited marked antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Escherichia coli, Salmonella typhi & Proteus mirabilis. The leaves of Acanthus montanus are used in traditional herbal practices in South Eastern Nigeria & in some other parts of West Africa for the treatment of gonorrhoea, syphilis, wounds & boils.
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According to Okoli CO (2008)
Excerpt The aqueous root extract (obtained by hot water maceration of the root powder) was studied for effects on the growth of clinically isolated strains of Pseudomonas aeruginosa & Staphylococcus aureus. Acanthus montanus (Nees) T.
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According to Adamu M (2010)
Excerpt The anthelminthic efficacy of the crude aqueous extract of Acanthus montanus (Nees) T.
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According to Adeyemi OO (1999)
Excerpt The effects of the methanolic extract of Acanthus montanus on different smooth muscle preparations have been investigated. The extract also caused a concentration-dependent relaxation of the KCl-precontracted taenia coli of the guinea-pig which was partially blocked by propranolol (3×10−5 M) that completely blocked isoprenaline (10−8–3×10−4 M) relaxation of the tissue.
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According to Igwe OU (2014)
Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.
Evolution of this plant record
Under the CTA · public change history
First public publication
+2 indications · −2 indications · +3 synergies
Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Full bibliographic texts for new, corrected, or removed references expand below.
+18 references
Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Full bibliographic texts for new, corrected, or removed references expand below.
+18 references — show text
Enitan A et al, Evaluation of different solvents for extraction of phytochemical constituents & antioxidant activities of the leaves of Acanthus montanus (Nees) T. Anderson, Lekovite Sirovine, 2021-Abstrac:Bear's breech or mountain thistle (Acanthus montanus (Nees) T. Anderson) is a shrub belonging to Acanthaceae family. It is widespread in Africa, Romania, Greece, & Eastern Mediterranean. African people engage its medicinal use for the management of urethral pain, endometritis, urogenital infections, urinary disease, aches & pains. Fresh leaves of AM were collected from Forestry Research I…
AddedPatric-Iwuanyanwu K C et al, Prevention of carbon tetrachloride (CCl4)-induced liver damage in rats by Acanthus montanus. Asian J. of Biochem, 3(4), 213-20, 2008-Abstract: the hepatoprotective effects of aqueous & alcoholic extracts of stem & leaf of Acanthus montanus pre-treatment against carbon tetrachloride (CCl4,)-induced liver damage in wistar albino rats were investigated. The plant extracts were fed to the rats intragastricaly for 15 days prior to the administration of 0.5 mL CCl4 kg-1 body weight. Serum L-alanine aminotransferase (L-ALT), L-aspartate amino transferase (L-AST), lacta…
AddedAdamu M et al, Anthelminthic Efficacy of Aqueous Extract of Acanthus Montanus Leaf Against Strongylid Nematodes of Small Ruminants, Afr J of Comp Alter Med, 7:4, 2010-Abstract: The anthelminthic efficacy of the crude aqueous extract of Acanthus montanus (Nees) T. Anders (Acanthaceae) against strongylid nematodes of small ruminants was investigated using the in-vitro egg hatch & larval growth inhibition assays. Faecal samples collected per rectum from sheep and goats were subjected to parasitological examination using the McMaster counting technique with a yield of 700 eggs per gram (E.P.G.)…
AddedAsongalem EA et al, Anti-inflammatory, lack of central analgesia & antipyretic properties of Acanthus montanus (Ness) T. Anderson. J Ethnopharmacol. 2004;95:63–8-Abstract : Aqueous leaves extract of Acanthus montanus (Nees) T. Anderson (Acanthaceae) were tested for antiinflammatory, analgesic & antipyretic properties. This was done using standard methodologies following oral administration of the extract. The results showed that the extract significantly reduced the oedema induced by carrageenanwithin 30 min with 200 mg/kg being the most potent. On the analgesia front, acetic acid writhing …
AddedFoyet HS et al, TOCOLYTIC EFFECT OF ACANTHUS MONTANUS IN RAT UTERUS, Pharmacologyonline 3 : 9-17, 2006-Abstract : The objective of this study was to investigate the tocolytic efficacy of A. montanus (Nees) T. Anderson (Acanthaceae) as a possible remedy for threatened abortion & dysmenorrhea. Aqueous & organic extracts & fractions of dried leaves prepared with different solvents (hexane, ethyl acetate & methanol) were tested in vitro for relaxant activity on rat uterus. Aqueous & organic extracts exhibited relaxant properties with the EC5values of 3.0 & 0.27 mg/ml respectively. Each extract…
AddedOgundajo A et al, Inhibition of α‐amylase & α‐glucosidase by Acanthus montanus leaf extracts. British J of Pharmaceuti Res, 9, 1–8.2016-Abstract: The aim of this study was to determine the in-vitroanti-diabetic potentials of Acanthus montanus. This was done by assessing the inhibitory effect of both methanol & ethylacetate extracts of the plant on the activities of α-amylase & α-glucosidase. Study Design: The design included extraction of A. montanus leaves with methanol & ethanol & subsequent evaluation of the extracts for possible hypoglycemic effect. Place & Duration of Study: The leave…
AddedOmekannaya B et al, Effects Of Methanol Extract Of Acanthus Montanus Leaves On Liver Function Induces Of Paracetamol Induced Male Wist Ar Albino Rats, Repository.mouau.edu.ng, 2023-Abstract:The study investigated the effects of methanol extract of Acanthus montanus leaves on liver function indices of paracetamol induced male albino rats. A total of 36 male rats & l 8 mice were used for the study. The rats were grouped into 9 groups of 4 animals each. Group I served as normal control, group 2 served as negative control, group 3 served as drug control, group 4: 200 mg/kg bwt of extract group,…
AddedUkwe CV et al, Hypoglycemic activity of leaves of Acanthus montanus T. Anderson (Acanthaceae) in rats. Inter J of Diabetes in Developing Countries, 31, 32, 2011-Abstract: Hypoglycemic activity of Acanthus montanus, used locally in Nigeria to “cure” diabetes, was evaluated. Phytochemical tests & acute toxicity tests were carried out on the methanolic extract. Using normoglycemic & alloxanized (alloxan monohydrate 70 mg/kg IV body weight) rats, pre-treatment was done with 400 mg/kg of the extract & glibenclamide 10 mg/kg as reference drug orally. Blood glucose levels of the rats were measured…
AddedMatos P et al, A review of the ethnomedicinal uses, chemistry, & pharmacological properties of the genus Acanthus (Acanthaceae), J of Ethnopharmacol, 293 :115271, 2022-Abstract: The Acanthus genus belongs to the Acanthaceae family, & its species are distributed in all continents, mainly in tropical and subtropical regions. Several traditional applications are referred to, but few scientific studies validate them. Despite this, studies in animal models corroborate some of its uses in folk medicine, such as anticancer, antidiabetic, anti-inflammatory, & antinociceptive, which encourages the r…
AddedAdeyemi OO et al, the relaxant activity of the methanolic extract of Acanthus montanus on intestinal smooth muscles. J Ethnopharmacol. 1999;68:169–73-Abstract: The effects of the methanolic extract of Acanthus montanus on different smooth muscle preparations have been investigated. The extract (6.25–100 μg/ml) produced a concentration-dependent relaxation & inhibition of the spontaneous contraction of the rabbit jejunum which was reversed by CaCl2 (0.1–1mM). This effect of the extract was not blocked by propranolol (3×10−7 M) but partially antagonised by phentolamine (10−6–3×10−6 M), procai…
AddedOkoli CO et al, Acanthus montanus: An experimental evaluation of the antimicrobial, anti-inflammatory & immunological properties of a traditional remedy for furuncle, BMC COMP & ALTER MED, 8(1):27, 2008-Abstract: Acanthus montanus (Nees) T. Anderson (Acanthaceae) is a shrub widespread in Africa, the Balkans, Romania, Greece & Eastern Mediterranean. It is used in African traditional medicine for the treatment of urogenital infections, urethral pain, endometritis, urinary disease, cystitis, leucorrhoea, aches & pains. In southeastern Nigeria, the root is popular & acclaimed highly effective i…
AddedNana P et al, Maternal & developmental toxicity evaluation of Acanthus montanus leaves extract administered orally to Wistar pregnant rats during organogenesis, J of Ethnopharmacol, 116(2):228-33, 2008-Abstract: Acanthus montanus is a plant used in Cameroon to treat pains & threatened abortion. The aim of this study was to evaluate the influence of methanol/methylene chlorides leaves extract from AM on Wistar pregnant rats & identify the substance(s) essential for these actions. Dams were treated orally from days 6 to 15 of the pregnancy at the dose levels of 0, 250, 500 & 1000 mg/ (kg-day)…
AddedDjami TAT et al, Subacute toxicity study of the aqueous extract from Acanthus montanus. Electronic J of Biol, 7, 11–15. 2011,
AddedIgwe OU et al, Chemical Characterization & Investigation of the Bio- effects of the Leaves of Acanthus montanus (Acanthaceae) on Some Selected Microorganisms, Inter J of Chem Tech Res, 6(4):5554-61, 2014-Abstract: The leaves of Acanthus montanus are used in traditional herbal practices in South Eastern Nigeria & in some other parts of West Africa for the treatment of gonorrhoea, syphilis, wounds & boils. Other uses of AM in herbal medicine include the treatment of hypertension, cardiac dysfunctions, hepatitis & heart diseases. The chemical constituents of the ethanolic extract of the leaves…
AddedIkezu UJ et al, Structural elucidation & antimicrobial analysis of chloroform leaf extract of Acanthus montanus . IOSR J of Applied Chem, 7, 72–5, 2014,
AddedLowe A et al, Effect of processing on the biochemical contents of Acanthus montanus (Nees) T. Anderson (Acanthaceae) leaves, Food Sci Nutr, 6(2) :388-84, 2018-Abstract: The effect of processing on the biochemical contents of Acanthus montanus leaves was investigated. The moisture, crude protein, lipid, fiber, ash, & total carbohydrate contents of the raw vegetable were 59.15, 1.85, 2.32, 3.76, 2.04, & 34.65 g/100 g, respectively. The saponin, alkaloid, tannin, flavonoid, phenol, & anthocyanin contents of the raw vegetable were 5.35, 4.04, 1.10, 3.53, 2.87, & 1.27 g/100 g, respectively, whil…
AddedNgo Bun E et al, Validation of anticonvulsant & sedative activity of six medicinal plants, Epilepsy & Behavior, 14(3) :454-8, 2009-Abstract : Acanthus montanus, Alchornea laxiflora, Hyptis spicigera, Microglossa pyrifolia, Piliostigma reticulatum, & Voacanga africana were evaluated with respect to anticonvulsant & sedative activity in mice using animal models (maximal electroshock (MES), N-methyl-D-aspartate (NMDA), pentylenetetrazol (PTZ), isonicotinic hydrazide acid (INH), picrotoxin (PIC), and strychnine (STR)-induced convulsions or turning behavior & diazepam-induced sleep). A montanus …
AddedOjiako OA et al, Comparative Hypoglycemic Activities of Aqueous & Ethanolic Extracts of Four Medicinal Plants (Acanthus Montanus, Asystasia gangetica, Emilia coccinea & Hibiscus rosa sinensis) in Type I Diabetic Rats, J Comp Med Res. 2015; 4(3): 228-33-Abstract: The present study ascertained the capacities of crude aqueous & ethanolic leaf extracts of Acanthus Montanus, Asystasia gangetica, Emilia coccinea & Hibiscus rosa sinensis, as well as their Combinatorial formulations to ameliorate hyperglycemia in Type I diabetic rats. Methods: Hyperglycemia was induced by single intra-peritoneal in…
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