Agaricus blazei (Agaric) : medicinal properties in alcoholic extraction

Agaricus blazei (Agaric, Sun mushroom, Matsutake, Champignon du soleil) — family Agaricacées.

Scientific synonyms : Agaricus brasiliensis-Wasser, Didukh, A rufotegulis, var hadriaticus- L & N, Fungus subfrutescens-Ktze, Pasollota subfrutescens-(Ktze)-Kaujjman..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 118 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of gastric, liver, lung (non-small cell) and squamous cell carcinoma of the tongue

   Plant part used: Mycelium.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Tung YC (2012)

     Excerpt SK-Hep-1 & HA22T/VGH cells are poorly differentiated human hepatocellular carcinoma cell lines with invasive and migratory abilities. Agaricus blazei (AB) is a mushroom with many biological effects & active ingredients, & the ethanolic extract of AB fermentation product (AB-pE) was demonstrated to inhibit the growth of hepatoma Hep3B & HepG2 cells in our previous study.

   • According to Su ZY (2011)

     Excerpt Hepatocellular carcinoma is the most common type of liver cancer. Previously, it was reported that blazeispirol A (BA) is the most active antihepatoma compound in an ethanolic extract of Agaricus blazei fermentation product.

   • According to Satoshi Ohno (2011)

     Excerpt Although many cancer patients use complementary and alternative medicine, including Agaricus blazei Murill (ABM), safety is not yet well understood. Adverse events were defined by subjective/objective symptoms & laboratory data

   • Excerpt according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 (NCI-CTCAE v3.0).

   • According to da Silva de Souza AC (n.d.)

     Excerpt At least the following bioactivities can be considered as being supported by experimental evidence: antioxidant activity (in aging or disease), immunomodulation & cell signaling, anti-inflammatory activity, antiparasitic actions, antimicrobial activity, anticancer effects & tumor growth inhibiting effects, antimutagenic activity, hepatoprotection against chemical or viral infection & antidiabetic activity. The mushroom Agaricus blazei has evoked considerable scientific & practical interest in several fields, especially those linked to its medicinal properties.

   • According to Hisamochi A (2013)

     Excerpt Their clinical courses from the start of CAM until the onset of DILI were observed unexpectedly, because they were under observation for stable malignant neoplasms: stage III malignant thymoma & stage IV lung cancer, respectively. Agaricus blazei Murill (ABM) is one of the most popular complementary alternative medicines (CAM).

2. 2

   Type II diabetes mellitus

   Plant part used: Mycelium.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Firenzuoli, L (2008)

     Excerpt Agaricus blazei Murill (ABM) popularly known as ‘Cogumelo do Sol’ in Brazil, or ‘Himematsutake’ in Japan, is a mushroom native to Brazil, & widely cultivated in Japan for its medicinal uses, so it is now considered as one of the most important edible & culinary-medicinal biotechnological species. It was traditionally used to treat many common diseases like atherosclerosis, hepatitis, hyperlipidemia, diabetes, dermatitis & cancer.

   • According to Wei Q (2019)

     Excerpt Agaricus blazei Murill (ABM), a medicinal mushroom, has beneficial effects on various human metabolic diseases. The objective of this research was to evaluate the antioxidant & antidiabetic properties of ABM extracts (ethanol extract & ethyl acetate extract).

   • According to Hsu CH (2007)

     Excerpt This study was done to determine whether the supplement of Agaricus blazei Murill extract improves insulin resistance in type 2 diabetes. The enrolled patients were randomly assigned to either receiving supplement of Agaricus blazei Murill (ABM) extract or placebo (cellulose) 1500 mg daily for 12 weeks.

   • According to Vincent, M (2013)

     Excerpt The present study aimed to test whether supplementation with Agaricus blazei Murill (ABM) extract could have an effect on diet-induced obesity in rats. Dietary supplement may potentially help to fight obesity and other metabolic disorders such as insulin-resistance a& low-grade inflammation.

   • According to da Silva de Souza AC (n.d.)

     Excerpt The mushroom Agaricus blazei has evoked considerable scientific & practical interest in several fields, especially those linked to its medicinal properties. At least the following bioactivities can be considered as being supported by experimental evidence: antioxidant activity (in aging or disease), immunomodulation & cell signaling, anti-inflammatory activity, antiparasitic actions, antimicrobial activity, anticancer effects & tumor growth inhibiting effects, antimutagenic activity, hepatoprotection against chemical or viral infection & antidiabetic activity.

3. 3

   Liver disorders: cirrhosis, hepatitis, fatty liver disease

   Plant part used: Mycelium.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hisamochi A (2013)

     Excerpt We experienced a case of a 60-year-old woman with severe hepatitis associated with extract of ABM & extract of Ganoderma lucidum, & a case of a 75-year-old man with drug-induced liver injury (DILI) associated with extract of ABM & fucoidan. The second point was that histological findings of the liver were very similar to autoimmune hepatitis (AIH).

   • According to Hsu CH (n.d.)

     Excerpt This 1-year open-label pilot study aims to observe whether Agaricus blazei Murill extract improves liver function in patients with hepatitis B. Four (4) patients with hepatitis B who met the criteria (1) aged between 20 & 65 years; (2) being Chinese; (3) having been a hepatic B carrier (HBAg (+)) for more than 3 years; (4) alanine amino-transferase > 100 IU/L; & (5) not taking lamivudine, alpha-interferon, or other drugs for hepatitis participated in the study with informed consent.

   • According to Tung YC (2012)

     Excerpt Agaricus blazei (AB) is a mushroom with many biological effects & active ingredients, & the ethanolic extract of AB fermentation product (AB-pE) was demonstrated to inhibit the growth of hepatoma Hep3B & HepG2 cells in our previous study. SK-Hep-1 & HA22T/VGH cells are poorly differentiated human hepatocellular carcinoma cell lines with invasive and migratory abilities.

   • According to Su ZY (2011)

     Excerpt Previously, it was reported that blazeispirol A (BA) is the most active antihepatoma compound in an ethanolic extract of Agaricus blazei fermentation product. Hepatocellular carcinoma is the most common type of liver cancer.

   • According to Al-Dbass AM (2012)

     Excerpt The findings indicate that the extract of AB can protect the liver against carbon tetrachloride induced oxidative damage in rats & is an efficient hepatoprotective & antioxidant agent against carbon tetrachloride induced liver injury. Also increase level of non-enzymatic antioxidant along with the decrease level in malondialdehyde was found in all experimental animals which were treated with Agaricus blazei Mushroom extract as compared with normal controls.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.