Aloe vera (Lalwé) : medicinal properties in alcoholic extraction

Aloe vera (Lalwé, Aloe, Aloès) — family Asphodeliacées.

Scientific synonyms : Aloe Barbadensis-Mill, A. Flava-Ros, A.elongata-Murr, A. perfoliata-L, var. Vera, A.vulgaris-Lam.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 59 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Diabetic foot ulcer

   Plant part used: SHEET (GEL).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mohan D (2014)

     Excerpt Mohan D et al, an in vivo & in vitro investigation of the effect of Aloe vera gel ethanolic extract using animal model with diabetic foot ulcer, J Pharm Bio all. 2014, 6(3): 205–12-Aim: To examine the preventive effect of Aloe vera gel ethanolic extract using diabetic foot ulcer (DFUs) protocol in Wistar rats.

   • According to Valentine UN (2018)

     Excerpt This study was aimed at determining the phytochemical analysis & antibacterial activities of ethanol & methanol extract of Aloe vera leaves on bacteria isolated from diabetic foot ulcer patients. 150 swabs were obtained from diabetic foot ulcer patients in the hospital.

   • According to Rajasekaran S (2006)

     Excerpt The present study was designed to examine the potential Antihyperlipidaemic efficacy of the ethanolic extract from Aloe vera leaf gel in streptozotocin (STZ)-induced diabetic rats. Oral administration of A vera gel extract at a dose of 300 mg/kg bodyweight per day to STZ-induced diabetic rats for a period of 21 days resulted in a significant reduction in fasting blood glucose, hepatic transaminases (aspartate aminotransferase & alanine aminotransferase), plasma & tissue (liver and kidney) cholesterol, triglycerides, free fatty acids & phospholipids and a significant improvement in plasma insulin.

   • According to Rajasekaran S (2005)

     Excerpt This study was designed to evaluate the potential antioxidative activity of the ethanolic extract from Aloe vera leaf gel in the plasma & pancreas of streptozotocin (STZ)-induced diabetic rats. Oral administration of ethanolic extract at a concentration of 300 mg kg (-1) body weight for 21 days resulted in a significant reduction in fasting blood glucose, Thiobarbituric acid reactive substances, hydroperoxides & alpha-tocopherol & significant improvement in ascorbic acid, reduced glutathione & insulin in the plasma of diabetic rats.

   • According to Rajasekaran S (2005)

     Excerpt Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats.

2. 2

   Type II diabetes mellitus

   Plant part used: SHEET (GEL).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mohan D (2014)

     Excerpt Vera gel at a dose 30 mg/kg body weight per day to streptozotocin (STZ)-induced diabetic rats for a period of 9 days resulted in no change in blood glucose & plasma insulin. Vera gel ethanolic extract at a dose of 300 mg/kg body weight per day to diabetic rats for a period of 9 days resulted in a significant reduction in fasting blood glucose and a significant improvement in plasma insulin.

   • According to Rajasekaran S (2006)

     Excerpt The present study was designed to examine the potential Antihyperlipidaemic efficacy of the ethanolic extract from Aloe vera leaf gel in streptozotocin (STZ)-induced diabetic rats. Oral administration of A vera gel extract at a dose of 300 mg/kg bodyweight per day to STZ-induced diabetic rats for a period of 21 days resulted in a significant reduction in fasting blood glucose, hepatic transaminases (aspartate aminotransferase & alanine aminotransferase), plasma & tissue (liver and kidney) cholesterol, triglycerides, free fatty acids & phospholipids and a significant improvement in plasma insulin.

   • According to Rajasekaran S (2005)

     Excerpt This study was designed to evaluate the potential antioxidative activity of the ethanolic extract from Aloe vera leaf gel in the plasma & pancreas of streptozotocin (STZ)-induced diabetic rats. Oral administration of ethanolic extract at a concentration of 300 mg kg (-1) body weight for 21 days resulted in a significant reduction in fasting blood glucose, Thiobarbituric acid reactive substances, hydroperoxides & alpha-tocopherol & significant improvement in ascorbic acid, reduced glutathione & insulin in the plasma of diabetic rats.

   • According to Rajasekaran S (2005)

     Excerpt Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats.

   • According to Valentine UN (2018)

     Excerpt This study was aimed at determining the phytochemical analysis & antibacterial activities of ethanol & methanol extract of Aloe vera leaves on bacteria isolated from diabetic foot ulcer patients. Solvents such as ethanol & methanol were used to extract the leaves of Aloe vera and screened for their phytochemical & antibacterial activities using standard methods.

3. 3

   Cancer: adjuvant treatment of hepatocellular, lung, epithelial and uterine adenocarcinoma

   Plant part used: SHEET (GEL).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sudheer M (2011)

     Excerpt The methanolic extract of Plumeria alba (Apocynaceae) & aqueous extract of Aloe vera (Liliaceae) were tested for their hepatoprotective activity against CCl 4 induced hepatotoxicity in adult male Wistar rats. Plumeria alba & Aloe vera, are described as a hepatoprotective in Ayurveda, the Indian system of medicine.

   • According to Beya W (2012)

     Excerpt Short term administration of A-vera extracts resulted in growth promotion, enhanced hepatic storage of metabolic substrates, increased ALP possibly in relation to bone growth & caused hypertrophy of the caecum of neonatal rats. When nursing mothers use Aloe vera, their babies are at risk of indirect exposure to Aloe vera via breast feeding or directly as health supplements.

   • According to Karpagam T (2019)

     Excerpt Vera were investigated using 3-(4,5-dimethylthiazole-2yl) -2,5-diphenyl tetrazolium Bromide assay on three human cancer cell lines HepG2 (liver cancer), HeLa (human cervical carcinoma cell line) & A549 (human lung adenocarcinoma epithelial cell line). In the present study, anticancer & cytotoxicity of Aloe vera ethanolic leaves extract was evaluated as the leaves of A.

   • According to Jose J (2014)

     Excerpt The present study was designed to determine the comparative anticancer activities of flavonoids isolated from Aloe vera, Mimosa pudica & Phyllanthus niruri against human breast carcinoma cell line (MCF-7) using MTT assay. Results : Flavonoids isolated from A vera, M pudica & P niruri showed cytotoxicity activity against human breast carcinoma cell line (MCF-7) & the inhibitory concentration at 50% growth (IC50) was found to be, M pudica (IC50= 35.52±0.50µg/ml), A vera (IC50= 54.97±0.36µg/ml) & P niruri (IC50= 84.88±0.87µg/ml).

   • According to Madhavan S (2020)

     Excerpt The control group of 700μg was compared with ethanolic extract of A vera & observed that it reduced the expression of TNF α (Tumor necrosis factor) & Interleukin 6 (IL-6). In this study we performed phytochemical screening of various Aloe vera extracts to compare its bioactive potential.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.