Alstonia scholaris (Pali mari) : medicinal properties in alcoholic extraction

Alstonia scholaris (Pali mari, Bwa-djab, Devil’s tree, Bois-à-diable) — family Apocynacées.

Scientific synonyms : Echites scholaris-L-Mant..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 131 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nilubon JA (2007)

     Excerpt α-Glucosidase inhibitors are used in the treatment of non-insulin-dependent diabetes mellitus. Potent α-glucosidase inhibitory activity was found in aqueous methanol extract of dried Devil tree (Alstonia scholaris) leaves.

   • According to Arulmozhi S (2010)

     Excerpt Materials & methods: The streptozotocin-induced diabetic rats were orally treated with vehicle (2% w/v Tween 80), Glibenclamide (0.25mg/kg) & EEAS (100, 200 & 400mg/kg) to the respective treatment groups. scholaris (known as EEAS) in streptozotocin-induced diabetic rats.

   • According to Akhtar MS (2002)

     Excerpt To assess the hypoglycaemic effect of powdered Alstonia scholaris (Satona) leaves, 2 groups of normal (healthy) human volunteers & 4 groups of already diagnosed out-door patients suffering from non-insulin dependent diabetes mellitus (NIDDM) were randomly selected. The mechanism of this hypoglycaemic effect of the plant drug has been already suggested to be insulin triggering & direct insulin-like actions.

   • According to Soni P (2019)

     Excerpt The present study investigated the anticataract activity of a novel isoflavonoid, isolated from stem bark of Alstonia scholaris, against fructose-induced experimental cataract. Conclusion: Results revealed that administration of ASII played a crucial role in the reduction of cataract formation in diabetic and hypertensive models.

   • According to Ogbonnia S (2008)

     Excerpt Ogbonnia S et al, Evaluation of acute & subacute toxicity of Alstonia congensis Engler (Apocynaceae) bark & Xylopia aethiopica (Dunal) A. Rich (Annonaceae) fruits mixtures used in the treatment of diabetes.

2. 2

   Cancer: adjuvant treatment for oral, colorectal, breast and lung cancer, and neuroblastoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Keawpradub N (1997)

     Excerpt glaucescens, & A scholaris, collected from Thailand, have been assessed for cytotoxic activity against two human lung cancer cell lines, MOR-P (adenocarcinoma) & COR-L23 (large cell carcinoma), using the SRB assay. Methanol extracts of root barks of Alstonia macrophylla, A.

   • According to Wang C (2017)

     Excerpt scholaris, & assess the anti-proliferation effects of isolated compounds against non-small-cell lung carcinoma cells; (2) Methods: NMR was used to identify the chemical constitutes isolated from the leaf extract of AS. Ursolic acid, betulinic acid, betulin, and 2β,3β,28-lup-20(29)-ene-triol showed anti-proliferative activity against NSCLC, with IC50 of 39.8, 40.1, 240.5 & 172.6 μM, respectively.; (4) Conclusion: These findings reflect that pentacyclic triterpenoids are the anti-lung cancer chemicals in A.

   • According to Sharma V (2010)

     Excerpt The extracts of the leaves were screened for in vitro cytotoxicity by means of SRB assay on five human cancer cell lines: lung cancer cells (A-549), oral cancer cells (KB), breast cancer cells (MCF-7), neuroblastoma cancer cells (SK-N-MC) & colon cancer cells (SW-620). The aim of this research work was to evaluate the anticancer potential of leaf extracts from the traditional medicinal plant i.e., Alstonia scholaris.

   • According to Arulmozhi S (2007)

     Excerpt The plant Alstonia scholaris has been used in different system of traditional medication for the treatment of diseases & ailments of human beings. It has been reported as antimicrobial, antiamoebic, antidiarrhoeal, antiplasmodial, hepatoprotective, immunomodulatory, anti-cancer, antiasthmatic, free radical scavenging, antioxidant, analgesic, anti-inflammatory, anti-ulcer, anti-fertility a& wound healing activities.

   • According to Jagetia, GC (2004)

     Excerpt The Chemomodulatory activity of Alstonia scholaris extract (ASE) was studied in combination with berberine hydrochloride (BCL), a topoisomerase inhibitor, in Ehrlich ascites carcinoma-bearing mice. The combination of 180 mg/kg of ASE with 8 mg/kg of BCL showed the greatest antitumor effect; the number of tumor-free survivors was more, & the median survival time & the average survival time increased up to 47 and 40.5 days, respectively, when compared with either treatment alone.

3. 3

   Diarrhoea

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Salfuzzaman M et al (2013)

     Excerpt In antidiarrheal activity test (castor oil induced diarrhea), the extract was taken as a dose of 250mg/kg body weight orally in Swiss albino mice & the standard drug loperamide, at a dose of 50mg/kg. Alstonia scholaris (Apocynaceae) is an evergreen and tropical tree native to the Indian subcontinent and South-east Asia.

   • According to Shah AJ (2010)

     Excerpt This study was aimed to provide a pharmacological basis to the medicinal use of Alstonia scholaris as an antidiarrhoeal & antispasmodic by using in vivo & in vitro techniques. These results indicate that the crude extract of AS possesses antidiarrhoeal and spasmolytic effects, mediated possibly through the presence of CCB-like constituent(s) & this study provides a mechanistic base for its medicinal use in diarrhoea & colic,.

   • According to Arulmozhi S (2007)

     Excerpt The plant Alstonia scholaris has been used in different system of traditional medication for the treatment of diseases & ailments of human beings. It has been reported as antimicrobial, antiamoebic, antidiarrhoeal, antiplasmodial, hepatoprotective, immunomodulatory, anti-cancer, antiasthmatic, free radical scavenging, antioxidant, analgesic, anti-inflammatory, anti-ulcer, anti-fertility a& wound healing activities.

   • According to Dey A (2011)

     Excerpt Alstonia scholaris is a traditionally important medicinal plant. The plant is used in traditional, Ayurvedic, Unani, Homoeopathy & Siddha/Tamil types of alternative medicinal systems against different ailments such as asthma, malaria, fever, dysentery, diarrhea, epilepsy, skin diseases, snakebite etc.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.