Alstonia scholaris (Pali mari) : vertus médicinales en extraction alcoolique

Alstonia scholaris (Pali mari, Bwa-djab, Bois-à-diable, Devil’s tree) — famille Apocynacées.

Synonymes scientifiques : Echites scholaris-L-Mant..

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 10 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 131 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Feuille. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Nilubon JA (2007)

     Extrait α-Glucosidase inhibitors are used in the treatment of non-insulin-dependent diabetes mellitus. Potent α-glucosidase inhibitory activity was found in aqueous methanol extract of dried Devil tree (Alstonia scholaris) leaves.

   • Selon Arulmozhi S (2010)

     Extrait Materials & methods: The streptozotocin-induced diabetic rats were orally treated with vehicle (2% w/v Tween 80), Glibenclamide (0.25mg/kg) & EEAS (100, 200 & 400mg/kg) to the respective treatment groups. scholaris (known as EEAS) in streptozotocin-induced diabetic rats.

   • Selon Akhtar MS (2002)

     Extrait To assess the hypoglycaemic effect of powdered Alstonia scholaris (Satona) leaves, 2 groups of normal (healthy) human volunteers & 4 groups of already diagnosed out-door patients suffering from non-insulin dependent diabetes mellitus (NIDDM) were randomly selected. The mechanism of this hypoglycaemic effect of the plant drug has been already suggested to be insulin triggering & direct insulin-like actions.

   • Selon Soni P (2019)

     Extrait The present study investigated the anticataract activity of a novel isoflavonoid, isolated from stem bark of Alstonia scholaris, against fructose-induced experimental cataract. Conclusion: Results revealed that administration of ASII played a crucial role in the reduction of cataract formation in diabetic and hypertensive models.

   • Selon Ogbonnia S (2008)

     Extrait Ogbonnia S et al, Evaluation of acute & subacute toxicity of Alstonia congensis Engler (Apocynaceae) bark & Xylopia aethiopica (Dunal) A. Rich (Annonaceae) fruits mixtures used in the treatment of diabetes.

2. 2

   Cancer : traitement adjuvant du carcinome buccal, colorectal, mammaire, pulmonaire & du neuroblastome

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Keawpradub N (1997)

     Extrait glaucescens, & A scholaris, collected from Thailand, have been assessed for cytotoxic activity against two human lung cancer cell lines, MOR-P (adenocarcinoma) & COR-L23 (large cell carcinoma), using the SRB assay. Methanol extracts of root barks of Alstonia macrophylla, A.

   • Selon Wang C (2017)

     Extrait scholaris, & assess the anti-proliferation effects of isolated compounds against non-small-cell lung carcinoma cells; (2) Methods: NMR was used to identify the chemical constitutes isolated from the leaf extract of AS. Ursolic acid, betulinic acid, betulin, and 2β,3β,28-lup-20(29)-ene-triol showed anti-proliferative activity against NSCLC, with IC50 of 39.8, 40.1, 240.5 & 172.6 μM, respectively.; (4) Conclusion: These findings reflect that pentacyclic triterpenoids are the anti-lung cancer chemicals in A.

   • Selon Sharma V (2010)

     Extrait The extracts of the leaves were screened for in vitro cytotoxicity by means of SRB assay on five human cancer cell lines: lung cancer cells (A-549), oral cancer cells (KB), breast cancer cells (MCF-7), neuroblastoma cancer cells (SK-N-MC) & colon cancer cells (SW-620). The aim of this research work was to evaluate the anticancer potential of leaf extracts from the traditional medicinal plant i.e., Alstonia scholaris.

   • Selon Arulmozhi S (2007)

     Extrait The plant Alstonia scholaris has been used in different system of traditional medication for the treatment of diseases & ailments of human beings. It has been reported as antimicrobial, antiamoebic, antidiarrhoeal, antiplasmodial, hepatoprotective, immunomodulatory, anti-cancer, antiasthmatic, free radical scavenging, antioxidant, analgesic, anti-inflammatory, anti-ulcer, anti-fertility a& wound healing activities.

   • Selon Jagetia, GC (2004)

     Extrait The Chemomodulatory activity of Alstonia scholaris extract (ASE) was studied in combination with berberine hydrochloride (BCL), a topoisomerase inhibitor, in Ehrlich ascites carcinoma-bearing mice. The combination of 180 mg/kg of ASE with 8 mg/kg of BCL showed the greatest antitumor effect; the number of tumor-free survivors was more, & the median survival time & the average survival time increased up to 47 and 40.5 days, respectively, when compared with either treatment alone.

3. 3

   Diarrhée

   Partie usitée : Écorce.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Salfuzzaman M et al (2013)

     Extrait In antidiarrheal activity test (castor oil induced diarrhea), the extract was taken as a dose of 250mg/kg body weight orally in Swiss albino mice & the standard drug loperamide, at a dose of 50mg/kg. Alstonia scholaris (Apocynaceae) is an evergreen and tropical tree native to the Indian subcontinent and South-east Asia.

   • Selon Shah AJ (2010)

     Extrait This study was aimed to provide a pharmacological basis to the medicinal use of Alstonia scholaris as an antidiarrhoeal & antispasmodic by using in vivo & in vitro techniques. These results indicate that the crude extract of AS possesses antidiarrhoeal and spasmolytic effects, mediated possibly through the presence of CCB-like constituent(s) & this study provides a mechanistic base for its medicinal use in diarrhoea & colic,.

   • Selon Arulmozhi S (2007)

     Extrait The plant Alstonia scholaris has been used in different system of traditional medication for the treatment of diseases & ailments of human beings. It has been reported as antimicrobial, antiamoebic, antidiarrhoeal, antiplasmodial, hepatoprotective, immunomodulatory, anti-cancer, antiasthmatic, free radical scavenging, antioxidant, analgesic, anti-inflammatory, anti-ulcer, anti-fertility a& wound healing activities.

   • Selon Dey A (2011)

     Extrait Alstonia scholaris is a traditionally important medicinal plant. The plant is used in traditional, Ayurvedic, Unani, Homoeopathy & Siddha/Tamil types of alternative medicinal systems against different ailments such as asthma, malaria, fever, dysentery, diarrhea, epilepsy, skin diseases, snakebite etc.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.