Annona cherimola (Cherimoya) : medicinal properties in alcoholic extraction

Annona cherimola (Cherimoya, Chérimôl, Chérimole) — family Annonacées.

Scientific synonyms : Annona acutifolia-Saff ex REF, A odorata-L, A pubescens-Salisb, A tripetala-Aiton.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 44 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet. Mentioned synergistic association: Glibenclamide, Acarbose.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to CALZADA F (2023)

     Excerpt The antihyperglycemic activity of ethanolic extract from Annona cherimola Miller (EEAch) & its products were evaluated using in vivo & in silico assays. This research sorts in vivo & in silico pharmacological studies regarding the use of AC leaves as a source for the development of new potential antidiabetic agents for T2D control, such as flavonoids rutin & myricetin.

   • According to Valdes M (2023)

     Excerpt Both treatments were evaluated separately & in combination with the oral antidiabetic drugs (OADs) acarbose (Aca), metformin (Met), glibenclamide (Gli), & canagliflozin (Cana) in acute & subchronic assays. Ethanolic extract obtained from Annona cherimola Miller ( EEAc) & the flavonoid rutin (Rut) were evaluated in this study to determine their antihyperglycemic content, % HbA1c reduction, & antihyperlipidemic activities.

   • According to Quílez A.M (2018)

     Excerpt This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, & possible interactions with other drugs of the Annona species. Many investigations have been performed with extracts from the leaves, bark, fruit & seeds & have shown a wide range of pharmacological activities, such as antiprotozoal, antitumoural, antidiabetic, hepato-protective, anti-inflammatory & anxiolytic activities.

   • According to Jamkhande PG (2017)

     Excerpt Annona cherimola, commonly known as Custard apple has recently gained attention of researchers because of copious anticancer bioactive chemicals & nutrients. The crude extracts as well as isolated compounds from different plant parts exhibited pharmacological activities such as antidiabetic, antimicrobial, antidepressant, anxiolytic, antiviral, antitumor & cytoprotective.

   • According to MARTINEZ-SOLIS J (2022)

     Excerpt Annona cherimola Miller (Ac) is a plant used in Mexican traditional medicine for the treatment of diabetes. In this work, the tea infusion extracts obtained from 1.5 g of leaf powder from Ac collected in May (Ac-Ma), June (Ac-Jun), July (Ac-Jul), & August (AcAu) were evaluated on streptozocin-induced diabetic (STID) mice & for subchronic toxicity in STID & non-diabetic (ND) mice.

2. 2

   Cancer: adjuvant treatment for gastric adenocarcinoma

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Macuer-Guzman J (2019)

     Excerpt cherimola seeds against the human stomach gastric adenocarcinoma (AGS) cell line & the normal human gastric epithelial cell line (GES-1). Annona cherimola is a tree belonging to the family Annonacea, whose fruit (cherimoya) is very desirable, but its seeds are considered waste.

   • According to Jamkhande PG (2017)

     Excerpt Annona cherimola, commonly known as Custard apple has recently gained attention of researchers because of copious anticancer bioactive chemicals & nutrients. Plants of the Annonaceae family have a long history of medicinal use in the treatment of several disease conditions such as epilepsy, cardiac diseases, pathogenic infections, hemorrhage, ulcer, cancer, liver disorders & other ailments.

   • According to Ceramella J (2021)

     Excerpt we investigated the antioxidant & anticancer properties on melanoma cells of three Annona cherimola leaves extracts (ethanolic, methanolic & aqueous). The ethanolic extract showed the most promising & interesting anticancer activity, mostly on the malignant A2058 melanoma cell line (I50-C= 5.6±0.8 ng/mL), without exerting cytotoxicity on the normal cells.

   • According to Quílez A.M (2018)

     Excerpt Many of the assays were carried out with the isolated acetogenins in different lines of tumour culture cells and were found effective at very low doses even in multidrug-resistant tumours, & hence constitute promising compounds in the treatment of different types of cancers. This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, & possible interactions with other drugs of the Annona species.

   • According to Fuel M (2021)

     Excerpt The antitumor effect of these extracts was evaluated in vitro with colorectal cancer (CRC) cell lines T84, HCT-15, SW480 & HT-29, as well as with cancer stem cells (CSCs). Moringa oleifera, Tropaeolum tuberosum & Annona cherimola are medicinal plants traditionally used in Ecuador.

3. 3

   Amoebiasis, diarrhoea, amoebic dysentery: Entamoeba histolytica & Giardia lamblia

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Calzada F (2017)

     Excerpt Results: The in vitro antiprotozoal assay showed that kaempferol was the most potent antiamoebic & antigiardial compound with IC50 values of 7.9 μg/mL for Entamoeba histolytica & 8.7 μg/mL for Giardia lamblia. Annona cherimola Miller (Annonaceae) is a medicinal plant frequently recommended in Mexican traditional medicine for the treatment of gastrointestinal disorders such as diarrhea & dysentery.

   • According to Bories C (1991)

     Excerpt cherimolia (Annonaceae) seeds were tested for antiparasitic activity against E.

   • According to Quílez A.M (2018)

     Excerpt This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, & possible interactions with other drugs of the Annona species. Many investigations have been performed with extracts from the leaves, bark, fruit & seeds & have shown a wide range of pharmacological activities, such as antiprotozoal, antitumoural, antidiabetic, hepato-protective, anti-inflammatory & anxiolytic activities.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.