Annona muricata (Kowosôl) : medicinal properties in alcoholic extraction

Annona muricata (Kowosôl, Soursop, Corossol) — family Annonacées.

Scientific synonyms : ---.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 32 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 159 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of hepatocellular carcinoma, ascites-associated lymphoma, promyelocytic leukaemia

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Liu N (2016)

     Excerpt AIM OF STUDY: The study investigated the molecular mechanisms underlying liver cancer cell apoptosis triggered by the ethanol extract of leaves of A muricata. Extracts of A muricata have been shown to cause apoptosis of various cancer cells in vitro, & inhibit tumor growth in vivo in animal models.

   • According to Thomas SV (2019)

     Excerpt To evaluate the anticancer potentials of Annona muricata fruit by in vitro & in vivo methods. In the in vivo studies, the DEN-control group showed a significant decrease in body weights with increased mortality rate, hepatic nodules, & impairment of liver function compared to normal rats.

   • According to Moghadamtousi S.Z (2015)

     Excerpt Numerous investigations have substantiated these activities, including anticancer, anticonvulsant, anti-arthritic, antiparasitic, antimalarial, hepatoprotective and antidiabetic activities. Annona muricata is a member of the Annonaceae family&d is a fruit tree with a long history of traditional use.

   • According to Abdul-Wahab SM (2018)

     Excerpt Different parts of AM especially the leaves have been used for various ethnomedicinal purposes by traditional healers to treat several diseases including cancer, inflammation, diabetes, liver diseases, & abscesses. Further in vitro & in vivo studies should be carried out to explore the molecular mechanisms underlying their anti-inflammatory responses in relation to anticancer activity & more detail toxicity study to ensure they are safe for human consumption.

   • According to Shukry M (2020)

     Excerpt Our results showed that MSG caused a significant increase in oxidative stress markers malondialdehyde (MDA), reactive oxygen species (ROS), nitric oxide (NO), hydrogen peroxide (H2O2), proinflammatory cytokines interleukin 6 (IL-6) level, a tumor protein (P53), hepatic cellular damage, as well as proapoptotic markers caspase-3, & B-cell lymphoma 2 (BCL-2)-like protein 4 (Bax). Besides, Graviola reduced the expression of inducible nitric oxide synthase (iNOS) and hepatic fatty acid synthase (FAS) & led to the upregulation of the silent information regulator protein one gene expression gene (SIRT1).In conclusion, the results suggest that Gaviola's interrelated antiapoptotic, antioxidant, & anti-inflammatory properties are potential mechanisms to enhance hepatic deficits & protect the liver.

2. 2

   Type II diabetes mellitus

   Plant part used: Fruit (flesh).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Akinlolu O (2023)

     Excerpt In this work, an attempt was made to study the hematological & hypoglycemic effects of Annona muricata ripe fruits pulp in Streptozotocin (STZ)-induced diabetic rats & validates its traditional claim. These results indicate that ripe fruits pulp of AM possesses a strong hypoglycemic effect in STZ–induced diabetic rats, thus supporting its traditional use in the management of diabetes mellitus.

   • According to Quillez M (2018)

     Excerpt Aim of the study : This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, and possible interactions with other drugs of the Annona species. Many investigations have been performed with extracts from the leaves, bark, fruit & seeds & have shown a wide range of pharmacological activities, such as antiprotozoal, antitumoral, antidiabetic, hepatoprotective, anti-inflammatory & anxiolytic activities.

   • According to Moghadamtousi S.Z (2015)

     Excerpt Annona muricata is a member of the Annonaceae family&d is a fruit tree with a long history of traditional use. Numerous investigations have substantiated these activities, including anticancer, anticonvulsant, anti-arthritic, antiparasitic, antimalarial, hepatoprotective and antidiabetic activities.

   • According to Ahalya B (2014)

     Excerpt The aim of present study was to demonstrate the Hypoglycemic & antidiabetic activity of the Ethanolic extract of Annona muricata stem bark in alloxan induced diabetic animals with a view to explore its use for the treatment of diabetes mellitus in humans. The Ethanolic extract of Annona muricata (Annonaceae) stem was investigated for its Antihyperglycemic & antihyperlipidemic effects in male albino rats.

   • According to Fitria-Ningsih, S (2014)

     Excerpt Jackfruit leaf (Artocarpus heterophyllus Lamk.) & Soursop leaf (Annona muricata L.) are some natural materials which empirically used for the treatment of Diabetes Mellitus.

3. 3

   Cyclophosphamide-induced hepatotoxicity

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Arhoghro EM (2020)

     Excerpt The aim of this study is to determine the protection of ethanolic Annona muricata (soursop) leaves extract on cyclophosphamide induced toxicity & oxidative stress in liver of male Wistar rat. The results showed that there was a significant increase (P˂0.05) in the enzyme levels compared to the control in albino male rat liver after the administration of the cyclophosphamide.

   • According to Usunomena U (2014)

     Excerpt The present study was conducted to evaluate the protective role of ethanolic leaf extract of Annona muricata on Diethylnitrosamine (DMN)-induced hepatotoxicity in rat model. Taken these data together, it can be concluded that natural plant components such as A muricata leaves could protect the liver against Diethylnitrosamine (DMN)-induced liver toxicity.

   • According to Quillez M (2018)

     Excerpt Aim of the study : This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, and possible interactions with other drugs of the Annona species. Many investigations have been performed with extracts from the leaves, bark, fruit & seeds & have shown a wide range of pharmacological activities, such as antiprotozoal, antitumoral, antidiabetic, hepatoprotective, anti-inflammatory & anxiolytic activities.

   • According to Abdul-Wahab SM (2018)

     Excerpt Further in vitro & in vivo studies should be carried out to explore the molecular mechanisms underlying their anti-inflammatory responses in relation to anticancer activity & more detail toxicity study to ensure they are safe for human consumption. Different parts of AM especially the leaves have been used for various ethnomedicinal purposes by traditional healers to treat several diseases including cancer, inflammation, diabetes, liver diseases, & abscesses.

   • According to Liu N (2016)

     Excerpt AIM OF STUDY: The study investigated the molecular mechanisms underlying liver cancer cell apoptosis triggered by the ethanol extract of leaves of A muricata. Annona muricata is used to treat cancer in some countries.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.