Annona muricata (Kowosôl) : vertus médicinales en extraction alcoolique

Annona muricata (Kowosôl, Corossol, Soursop) — famille Annonacées.

Synonymes scientifiques : ---.

Sources externes reconnues associées à cette monographie : TRAMIL.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 32 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 154 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome hépatique, lymphome d’ascite, leucémique promyelocytique

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Thomas SV (2019)

     Extrait To evaluate the anticancer potentials of Annona muricata fruit by in vitro & in vivo methods. In the in vivo studies, the DEN-control group showed a significant decrease in body weights with increased mortality rate, hepatic nodules, & impairment of liver function compared to normal rats.

   • Selon Moghadamtousi S.Z (2015)

     Extrait Numerous investigations have substantiated these activities, including anticancer, anticonvulsant, anti-arthritic, antiparasitic, antimalarial, hepatoprotective and antidiabetic activities. Annona muricata is a member of the Annonaceae family&d is a fruit tree with a long history of traditional use.

   • Selon Abdul-Wahab SM (2018)

     Extrait Different parts of AM especially the leaves have been used for various ethnomedicinal purposes by traditional healers to treat several diseases including cancer, inflammation, diabetes, liver diseases, & abscesses. Further in vitro & in vivo studies should be carried out to explore the molecular mechanisms underlying their anti-inflammatory responses in relation to anticancer activity & more detail toxicity study to ensure they are safe for human consumption.

   • Selon Shukry M (2020)

     Extrait Our results showed that MSG caused a significant increase in oxidative stress markers malondialdehyde (MDA), reactive oxygen species (ROS), nitric oxide (NO), hydrogen peroxide (H2O2), proinflammatory cytokines interleukin 6 (IL-6) level, a tumor protein (P53), hepatic cellular damage, as well as proapoptotic markers caspase-3, & B-cell lymphoma 2 (BCL-2)-like protein 4 (Bax). Besides, Graviola reduced the expression of inducible nitric oxide synthase (iNOS) and hepatic fatty acid synthase (FAS) & led to the upregulation of the silent information regulator protein one gene expression gene (SIRT1).In conclusion, the results suggest that Gaviola's interrelated antiapoptotic, antioxidant, & anti-inflammatory properties are potential mechanisms to enhance hepatic deficits & protect the liver.

   • Selon Quillez M (2018)

     Extrait Aim of the study : This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, and possible interactions with other drugs of the Annona species. Many of the assays were carried out with the isolated acetogenins in different lines of tumour culture cells & were found effective at very low doses even in multidrug-resistant tumours, & hence constitute promising compounds in the treatment of different types of cancers.

2. 2

   Diabète mellitus de type II

   Partie usitée : fruit (pulpe).

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Akinlolu O (2023)

     Extrait In this work, an attempt was made to study the hematological & hypoglycemic effects of Annona muricata ripe fruits pulp in Streptozotocin (STZ)-induced diabetic rats & validates its traditional claim. These results indicate that ripe fruits pulp of AM possesses a strong hypoglycemic effect in STZ–induced diabetic rats, thus supporting its traditional use in the management of diabetes mellitus.

   • Selon Quillez M (2018)

     Extrait Aim of the study : This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, and possible interactions with other drugs of the Annona species. Many investigations have been performed with extracts from the leaves, bark, fruit & seeds & have shown a wide range of pharmacological activities, such as antiprotozoal, antitumoral, antidiabetic, hepatoprotective, anti-inflammatory & anxiolytic activities.

   • Selon Moghadamtousi S.Z (2015)

     Extrait Annona muricata is a member of the Annonaceae family&d is a fruit tree with a long history of traditional use. Numerous investigations have substantiated these activities, including anticancer, anticonvulsant, anti-arthritic, antiparasitic, antimalarial, hepatoprotective and antidiabetic activities.

   • Selon Ahalya B (2014)

     Extrait The aim of present study was to demonstrate the Hypoglycemic & antidiabetic activity of the Ethanolic extract of Annona muricata stem bark in alloxan induced diabetic animals with a view to explore its use for the treatment of diabetes mellitus in humans. The Ethanolic extract of Annona muricata (Annonaceae) stem was investigated for its Antihyperglycemic & antihyperlipidemic effects in male albino rats.

   • Selon Fitria-Ningsih, S (2014)

     Extrait Jackfruit leaf (Artocarpus heterophyllus Lamk.) & Soursop leaf (Annona muricata L.) are some natural materials which empirically used for the treatment of Diabetes Mellitus.

3. 3

   Hépatotoxicité induite par le Cyclophosphamide

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Arhoghro EM (2020)

     Extrait The aim of this study is to determine the protection of ethanolic Annona muricata (soursop) leaves extract on cyclophosphamide induced toxicity & oxidative stress in liver of male Wistar rat. The results showed that there was a significant increase (P˂0.05) in the enzyme levels compared to the control in albino male rat liver after the administration of the cyclophosphamide.

   • Selon Auteur (2014)

     Extrait The present study was conducted to evaluate the protective role of ethanolic leaf extract of Annona muricata on Diethylnitrosamine (DMN)-induced hepatotoxicity in rat model. Taken these data together, it can be concluded that natural plant components such as A muricata leaves could protect the liver against Diethylnitrosamine (DMN)-induced liver toxicity.

   • Selon Quillez M (2018)

     Extrait Aim of the study : This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, and possible interactions with other drugs of the Annona species. Many investigations have been performed with extracts from the leaves, bark, fruit & seeds & have shown a wide range of pharmacological activities, such as antiprotozoal, antitumoral, antidiabetic, hepatoprotective, anti-inflammatory & anxiolytic activities.

   • Selon Abdul-Wahab SM (2018)

     Extrait Further in vitro & in vivo studies should be carried out to explore the molecular mechanisms underlying their anti-inflammatory responses in relation to anticancer activity & more detail toxicity study to ensure they are safe for human consumption. Different parts of AM especially the leaves have been used for various ethnomedicinal purposes by traditional healers to treat several diseases including cancer, inflammation, diabetes, liver diseases, & abscesses.

   • Selon Thomas SV (2019)

     Extrait In the in vivo studies, the DEN-control group showed a significant decrease in body weights with increased mortality rate, hepatic nodules, & impairment of liver function compared to normal rats. To evaluate the anticancer potentials of Annona muricata fruit by in vitro & in vivo methods.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.