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Annona squamosa (Apple and Cinnamon) : medicinal properties in alcoholic extraction

Annona squamosa (Apple and Cinnamon, Ponm-Kannèl, Pomme-cannelle) — family Annonacées.

Scientific synonyms : Annona asiatica L., A asiatica Vahl, A cinerea Dunal, A distincta Raüsch., A forskohlii DC., Guanabanus squamosus M. Gómez, Xylopia glabra L.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 31 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 181 scientific references for this species (full detail in the application).

Therapeutic indications in alcoholic extraction:

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

  1. Cancer: chemoprevention of hepatocellular carcinoma

    Plant part used: Sheet.

    Scientific references (short excerpts)

    Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

    • According to Vanitha V (2017)

      Excerpt Vanitha V et al, Fabrication of nanoparticles using Annona squamosa leaf & assessment of its effect on liver (Hep G2) cancer cell line IOP Conf.

    • According to MEHTA SD (2017)

      Excerpt Traditionally, Annona Squamosa Linn has been used for treatment of cancer, diabetes, microbial infection, cardiac disease, jaundice and other liver related disorder. Hence the current work aims to explore the hepatoprotective of the Annona Squamosa (AS) seeds.

    • According to VANITHA VKJ (2016)

      Excerpt The role of phytonutrients presents in the active ethyl acetate fraction of the ethanolic leaf Annona squamosa in regulating the balance between cell proliferation and apoptosis via modulating the expression pattern of proliferation & apoptosis regulating genes in HepG2 cell line was analyzed by studying the mRNA levels of two genes Bcl2, & P53 involved in apoptotic pathway. The effect of ethyl acetate fraction of ethanolic leaf extract of Annona squamosa (EAELAS) was studied on a HepG2 cell line.

    • According to Author (2008)

      Excerpt Studies on the seeds of Annona squamosa yielded a novel lipoxygenase inhibitor fatty acid ester, (+) - annonlipoxy (1). The crude ethanolic extract of fruit pulp & seeds of A squamosa also exhibited lipoxygenase activity with 22.2 & 26.7% inhibition, while the pet.

    • According to Ravaomanarivo LHR (2014)

      Excerpt To evaluate the potential efficacy of seed extracts of Annona squamosa & Annona muricata used as natural insecticides to control adult and larvae of the vectors Aedes albopictus & Culex quinquefasciatus under laboratory conditions. Extracts of A muricata induced high mortality rate to both species of mosquito compared to extracts of A squamosa at all concentrations tested.

  2. Type II diabetes mellitus

    Plant part used: Sheet.

    Scientific references (short excerpts)

    Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

    • According to Tomar RS (2014)

      Excerpt extract at a dose of 350 mg/kg and 700 mg/kg & Glibenclamide at a dose of 5mg/kg for 28 days, after induction of diabetes by alloxan, caused significant reduction in blood serum glucose and serum lipid profiles like total cholesterol and triglycerides but significant increase in body weight & serum high density Lipoproteins (HDL) level in diabetic rats compared to untreated group. Diabetes mellitus is characterized by rise in blood sugar levels resulting from insulin dysfunction or insulin insufficiency.

    • According to Gupta KR (2005)

      Excerpt The ethanolic extract of Annona squamosa leaves was administered orally at different doses to normal as well as streptozotocin (STZ)-induced diabetic rats & alloxan-induced diabetic rabbits. The same dose of ethanolic extract reduced FBG by 26.8% & improved glucose tolerance by 38.5 and 40.6% at 1 and 2 h, respectively, during GTT in alloxan-induced diabetic rabbits.

    • According to Saeed F (2017)

      Excerpt Aim of this research work was to explore the anti-diabetic activity and acute toxicity of Annona squamosa leaves ethanolic extract in albino rats & mice respectively. squamosa was administered orally in 100mg, 200mg & 400mg doses in three different groups of diabetes- induced rats.

    • According to MOUSSA AY (2024)

      Excerpt The main reported biological activities for AS were cytotoxic, antidiabetic, antimicrobial, antiparasitic, antioxidant, antimalarial, Molluscidal, anthelmintic & insecticidal activities, & its chemical classes encompassed alkaloids, diterpenes, acetogenins, & cyclopeptides.

    • According to Ponrasu T (2013)

      Excerpt Annona squamosa is known for its antioxidant, antidiabetic & wound healing activity. We examined the efficacy of AS on the levels of enzymatic & nonenzymatic antioxidants during wound repair in normal & streptozotocin induced diabetic rats.

  3. Hepatitis, cirrhosis, fatty liver disease

    Plant part used: Seed.

    Scientific references (short excerpts)

    Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

    • According to MEHTA SD (2017)

      Excerpt Traditionally, Annona Squamosa Linn has been used for treatment of cancer, diabetes, microbial infection, cardiac disease, jaundice and other liver related disorder. Hence the current work aims to explore the hepatoprotective of the Annona Squamosa (AS) seeds.

    • According to Author (2008)

      Excerpt Studies on the seeds of Annona squamosa yielded a novel lipoxygenase inhibitor fatty acid ester, (+) - annonlipoxy (1). The crude ethanolic extract of fruit pulp & seeds of A squamosa also exhibited lipoxygenase activity with 22.2 & 26.7% inhibition, while the pet.

    • According to VANITHA VKJ (2016)

      Excerpt The role of phytonutrients presents in the active ethyl acetate fraction of the ethanolic leaf Annona squamosa in regulating the balance between cell proliferation and apoptosis via modulating the expression pattern of proliferation & apoptosis regulating genes in HepG2 cell line was analyzed by studying the mRNA levels of two genes Bcl2, & P53 involved in apoptotic pathway. The effect of ethyl acetate fraction of ethanolic leaf extract of Annona squamosa (EAELAS) was studied on a HepG2 cell line.

    • According to Ravaomanarivo LHR (2014)

      Excerpt To evaluate the potential efficacy of seed extracts of Annona squamosa & Annona muricata used as natural insecticides to control adult and larvae of the vectors Aedes albopictus & Culex quinquefasciatus under laboratory conditions. Extracts of A muricata induced high mortality rate to both species of mosquito compared to extracts of A squamosa at all concentrations tested.

    • According to Rajeshkumar S (2015)

      Excerpt Rajeshkumar S et al, PHYTOCHEMICAL SCREENING & HEPATOPROTECTIVE EFFICACY OF LEAVES EXTRACTS OF ANNONA SQUAMOSA AGAINST PARACETAMOL INDUCED LIVER TOXICITY IN RATS Inter Jl of Pharmacogn, 2015-DOI: 10.13040/IJPSR.0975-8232.IJP,.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.

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Evolution of this plant record

Under the CTA · public change history

Content

+10 indications · −10 indications · +2 synergies · +13 references · −13 references

Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Full bibliographic texts for new, corrected, or removed references expand below.

+10 indications−10 indications+2 synergies+13 references−13 references
+13 references — show text
Yang X et al. A review on the chemical constituents of Annona plants 17(3):186-9, back cover, 1992Yang X · 1992

Yang X et al. A review on the chemical constituents of Annona plants 17(3):186-9, back cover, 1992

Added
Hopp DC et al, Mono-THF ring annonaceous acetogenins from Annona squamosa. Phytochem. 1998; 47(5):803-9.Hopp DC · 1998

Hopp DC et al, Mono-THF ring annonaceous acetogenins from Annona squamosa. Phytochem. 1998; 47(5):803-9.

Added
Gupta RK et al, In vivo evaluation of anti-oxidant & anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. Jl Ethnopharm 2008, 19; 118(1):21-5.Gupta RK · 2008

Gupta RK et al, In vivo evaluation of anti-oxidant & anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. Jl Ethnopharm 2008, 19; 118(1):21-5.

Added
Hopp DC et al, Three new bioactive bis-adjacent THF-ring acetogenins from the bark of Annona squamosa. Bioorg Med Chem. 1998, 6(5):569-75.Hopp DC · 1998

Hopp DC et al, Three new bioactive bis-adjacent THF-ring acetogenins from the bark of Annona squamosa. Bioorg Med Chem. 1998, 6(5):569-75.

Added
Shirwaikar A et al, In vitro antioxidant studies of Annona squamosa Linn. leaves. Indian J Exp Biol. 2004, 42(8):803-7.Shirwaikar A · 2004

Shirwaikar A et al, In vitro antioxidant studies of Annona squamosa Linn. leaves. Indian J Exp Biol. 2004, 42(8):803-7.

Added
Yang X et al, Studies on the chemical constituents of Annona squamosa, Acta Pharmaceutica Sinica 1992-Yang X · 1992

Yang X et al, Studies on the chemical constituents of Annona squamosa, Acta Pharmaceutica Sinica 1992-

Added
Chen Y et al, Monotetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa. Phytochem Letters 2012, 5 (1), 33-6-Abstract: Three new Monotetrahydrofuran annonaceous acetogenins, AnnosqChen Y · 2012

Chen Y et al, Monotetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa. Phytochem Letters 2012, 5 (1), 33-6-Abstract: Three new Monotetrahydrofuran annonaceous acetogenins, Annosquamosin A–C (1–3) were isolated from the 95% EtOH extract of Annona squamosa seeds, in addition to the known compounds, solamin, annotemoyin-1, uvariamicin-II, uvariamicin-III. Their structures were elucidated by spectroscopic analysis & the relative configurations of bearing tetrahydrofuran rings were established by comparing NMR data with model compounds,

Added
Panda S et al, Antidiabetic & antioxidative effects of Annona squamosa leaves are possibly mediated through quercetin-3-O-glucoside. Biofactors. 2007; 31(3-4):201-10.Panda S · 2007

Panda S et al, Antidiabetic & antioxidative effects of Annona squamosa leaves are possibly mediated through quercetin-3-O-glucoside. Biofactors. 2007; 31(3-4):201-10.

Added
Nagaraj B, Evaluation of Annona Squamosa Leaf Extract for its Adaptogenic & Antidepressant Activity, Thesis, Bangalore, 560041.-Abstract: Perusal of the literature survey indicates that there are no lUnknown

Nagaraj B, Evaluation of Annona Squamosa Leaf Extract for its Adaptogenic & Antidepressant Activity, Thesis, Bangalore, 560041.-Abstract: Perusal of the literature survey indicates that there are no literatures or studies were done on the Adaptogenic & Antidepressant activity of leaf extract of Annona squamosa. The uses of herbal drugs are being more popular. This study is designed to evaluate the Adaptogenic & Antidepressant activity of leaf extract of A squamosa.

Added
Chen Y et al. Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds. Jl of Ethnopharm. 2012; 142:462–6-Abstract: Three new bis-tetrahydrofuran annonaceous acChen Y · 2012

Chen Y et al. Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds. Jl of Ethnopharm. 2012; 142:462–6-Abstract: Three new bis-tetrahydrofuran annonaceous acetogenins (1–3) were isolated from a 95% EtOH extract of Annona squamosa seeds. Four known annonaceous acetogenins, uvarigrandin A (4), bullatacin (5), squamostatin-A (6), and squamostatin-D (7), were also isolated. Their structures were elucidated by spectroscopic analyses, and the absolute configurations of the carbinol centers of 1–3 were defined by application of the Mosher method. These co…

Added
Gupta RK et al. In vivo evaluation of anti-oxidant & anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. Jl of Ethnopharm 2008; 118(1):21–5.Gupta RK · 2008

Gupta RK et al. In vivo evaluation of anti-oxidant & anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. Jl of Ethnopharm 2008; 118(1):21–5.

Added
Panda S et al, Annona squamosa seed extract in the regulation of hyperthyroidism & d lipid-peroxidation in mice: possible involvement of quercetin. Phytomed. 2007; 14(12):799-805.-Abstract: Annona squPanda S · 2007

Panda S et al, Annona squamosa seed extract in the regulation of hyperthyroidism & d lipid-peroxidation in mice: possible involvement of quercetin. Phytomed. 2007; 14(12):799-805.-Abstract: Annona squamosa (Custard apple) seeds are generally thrown away as waste materials. The extract of these seeds was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in mouse model. Serum triiodothyronine (T (3)), thyroxine (T (4)) concentrations, hepatic glucose-6-phospatase (G-6-Pase) & 5'-mono-deiodinase (5'DI) activity were considered as the end parameters of thyroid …

Added
Shirwaikar A et al, Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin–nicotinamide type 2 diabetic rats, Jl of Ethnopharmacol, 91 (1): 171-5, 2004-doi: 10.1016/j.jep.2Shirwaikar A · 2004

Shirwaikar A et al, Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin–nicotinamide type 2 diabetic rats, Jl of Ethnopharmacol, 91 (1): 171-5, 2004-doi: 10.1016/j.jep.2003.12.017,

Added
Yang X et al. A review on the chemical constituents of Annona plants 17(3):186-9, back cover, 1992Yang X · 1992

Yang X et al. A review on the chemical constituents of Annona plants 17(3):186-9, back cover, 1992

Removed
Panda S et al, Antidiabetic & antioxidative effects of Annona squamosa leaves are possibly mediated through quercetin-3-O-glucoside. Biofactors. 2007; 31(3-4):201-10.Panda S · 2007

Panda S et al, Antidiabetic & antioxidative effects of Annona squamosa leaves are possibly mediated through quercetin-3-O-glucoside. Biofactors. 2007; 31(3-4):201-10.

Removed
Chen Y et al. Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds. Jl of Ethnopharm. 2012; 142:462–6-Abstract: Three new bis-tetrahydrofuran annonaceous acChen Y · 2012

Chen Y et al. Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds. Jl of Ethnopharm. 2012; 142:462–6-Abstract: Three new bis-tetrahydrofuran annonaceous acetogenins (1–3) were isolated from a 95% EtOH extract of Annona squamosa seeds. Four known annonaceous acetogenins, uvarigrandin A (4), bullatacin (5), squamostatin-A (6), and squamostatin-D (7), were also isolated. Their structures were elucidated by spectroscopic analyses, and the absolute configurations of the carbinol centers of 1–3 were defined by application of the Mosher method. These co…

Removed
Nagaraj B, Evaluation of Annona Squamosa Leaf Extract for its Adaptogenic & Antidepressant Activity, Thesis, Bangalore, 560041.-Abstract: Perusal of the literature survey indicates that there are no lUnknown

Nagaraj B, Evaluation of Annona Squamosa Leaf Extract for its Adaptogenic & Antidepressant Activity, Thesis, Bangalore, 560041.-Abstract: Perusal of the literature survey indicates that there are no literatures or studies were done on the Adaptogenic & Antidepressant activity of leaf extract of Annona squamosa. The uses of herbal drugs are being more popular. This study is designed to evaluate the Adaptogenic & Antidepressant activity of leaf extract of A squamosa.

Removed
Gupta RK et al. In vivo evaluation of anti-oxidant & anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. Jl of Ethnopharm 2008; 118(1):21–5.Gupta RK · 2008

Gupta RK et al. In vivo evaluation of anti-oxidant & anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. Jl of Ethnopharm 2008; 118(1):21–5.

Removed
Hopp DC et al, Mono-THF ring annonaceous acetogenins from Annona squamosa. Phytochem. 1998; 47(5):803-9.Hopp DC · 1998

Hopp DC et al, Mono-THF ring annonaceous acetogenins from Annona squamosa. Phytochem. 1998; 47(5):803-9.

Removed
Gupta RK et al, In vivo evaluation of anti-oxidant & anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. Jl Ethnopharm 2008, 19; 118(1):21-5.Gupta RK · 2008

Gupta RK et al, In vivo evaluation of anti-oxidant & anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. Jl Ethnopharm 2008, 19; 118(1):21-5.

Removed
Hopp DC et al, Three new bioactive bis-adjacent THF-ring acetogenins from the bark of Annona squamosa. Bioorg Med Chem. 1998, 6(5):569-75.Hopp DC · 1998

Hopp DC et al, Three new bioactive bis-adjacent THF-ring acetogenins from the bark of Annona squamosa. Bioorg Med Chem. 1998, 6(5):569-75.

Removed
Shirwaikar A et al, In vitro antioxidant studies of Annona squamosa Linn. leaves. Indian J Exp Biol. 2004, 42(8):803-7.Shirwaikar A · 2004

Shirwaikar A et al, In vitro antioxidant studies of Annona squamosa Linn. leaves. Indian J Exp Biol. 2004, 42(8):803-7.

Removed
Yang X et al, Studies on the chemical constituents of Annona squamosa, Acta Pharmaceutica Sinica 1992-Yang X · 1992

Yang X et al, Studies on the chemical constituents of Annona squamosa, Acta Pharmaceutica Sinica 1992-

Removed
Shirwaikar A et al, Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin–nicotinamide type 2 diabetic rats, Jl of Ethnopharmacol, 91 (1): 171-5, 2004-doi: 10.1016/j.jep.2Shirwaikar A · 2004

Shirwaikar A et al, Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin–nicotinamide type 2 diabetic rats, Jl of Ethnopharmacol, 91 (1): 171-5, 2004-doi: 10.1016/j.jep.2003.12.017,

Removed
Chen Y et al, Monotetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa. Phytochem Letters 2012, 5 (1), 33-6-Abstract: Three new Monotetrahydrofuran annonaceous acetogenins, AnnosqChen Y · 2012

Chen Y et al, Monotetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa. Phytochem Letters 2012, 5 (1), 33-6-Abstract: Three new Monotetrahydrofuran annonaceous acetogenins, Annosquamosin A–C (1–3) were isolated from the 95% EtOH extract of Annona squamosa seeds, in addition to the known compounds, solamin, annotemoyin-1, uvariamicin-II, uvariamicin-III. Their structures were elucidated by spectroscopic analysis & the relative configurations of bearing tetrahydrofuran rings were established by comparing NMR data with model compounds,

Removed
Panda S et al, Annona squamosa seed extract in the regulation of hyperthyroidism & d lipid-peroxidation in mice: possible involvement of quercetin. Phytomed. 2007; 14(12):799-805.-Abstract: Annona squPanda S · 2007

Panda S et al, Annona squamosa seed extract in the regulation of hyperthyroidism & d lipid-peroxidation in mice: possible involvement of quercetin. Phytomed. 2007; 14(12):799-805.-Abstract: Annona squamosa (Custard apple) seeds are generally thrown away as waste materials. The extract of these seeds was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in mouse model. Serum triiodothyronine (T (3)), thyroxine (T (4)) concentrations, hepatic glucose-6-phospatase (G-6-Pase) & 5'-mono-deiodinase (5'DI) activity were considered as the end parameters of thyroid …

Removed

By Emmanuel Nossin · ethnopharmacologist

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By Emmanuel Nossin · ethnopharmacologist