Apium graveolens (Celery) : medicinal properties in alcoholic extraction

Apium graveolens (Celery, Sèlri, Cèleri) — family Apiacées.

Scientific synonyms : Apium dulce-Mill.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 22 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 114 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for liver, colorectal and breast cancer

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to SHARMA V (2008)

     Excerpt Ethanolic extract of seeds of Apium graveolens showed a remarkable in vitro cytotoxicity against four human cancer cell lines of colon, CNS, oral & cervical origin. Results revealed that the most significant cytotoxic effect was observed in case of chloroform soluble & n-butanol soluble fractions as both inhibited the growth of eight human cancer cell lines of lung, liver, colon, CNS & ovarian origin.

   • According to Sultana S (2005)

     Excerpt The chemopreventive activity of methanolic extract of Apium graveolens seeds (celery seeds) has been investigated against Solt Farber protocol of hepatocarcinogenesis, oxidative stress & induction of positive foci of gamma-GT in the liver of Wistar rats. 2-AAF administration in diet with PH in rats resulted in increased hepatic ornithine decarboxylase (ODC) activity and a consequent increase in the rate of DNA synthesis when compared to saline treated control group while pretreatment of rats with celery seeds extract resulted in inhibition of aforementioned parameters dose dependently.

   • According to Ahmed QS (2012)

     Excerpt The present study was carried out to explore protective effects of ethanolic extract of Apium graveolens (celery seeds) on Ritonavir, a protease inhibitor induced dyslipidemia. Conclusion: Above results suggest that ethanolic extract of AG seeds possess potential for improving blood lipid profile & liver lipids deranged by Ritonavir when given concurrently.

   • According to Hussein EM (2007)

     Excerpt Present study was designed to evaluate anticancer effect of Apium graveolens seed extracts (aqueous, ethanolic & hexane extracts) in vitro on two cell lines (RD & L20B) using different concentrations of A. The results revealed a clear cytotoxic activity of those extracts on growth of RD cancer cell line, & the effect was concentration-dependent.

   • According to Köken T (2016)

     Excerpt Apium graveolens has been shown to inhibit the growth of a variety of cancer tissues. graveolens on the human prostatic carcinoma cell line LNCaP.

2. 2

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to MANSI KAMAL M (2014)

     Excerpt The aim of the present study is to assess the effects of ethanol extract derived from seeds of Apium graveolens on fertility of diabetic male rats. After thirty days of treatments, all rats were sacrificed & level of blood glucose, insulin, testosterone, follicle stimulating hormone (FSH) & luteinizing hormone (LH), weight of testis and epididymis and sperm count and motility were measured.

   • According to Kumar V (2012)

     Excerpt Stress represents a reaction of the body to a stimulus that tends to alter its normal physiological equilibrium or homeostasis, extreme stress leads to various complications like dépression, anxiety, immunosuppressant & endocrine disorder including diabetes mellitus, ulcérative colitis, obesity etc. The aqueous (200 mg kg-1) & ethanolic (400 mg kg-1) extracts concomitant administration have shown increase in anoxia stress tolerance time & swimming endurance time as compared to control group & also there was marked decrease in blood glucose, cholesterol, triglycerides & BUN level as compare to stress control group in cold stress model.

   • According to Adelakun EA (2021)

     Excerpt The results suggest that the Nigerian AG plant could be considered a good source of phthalides which are known for their nutraceutical properties such as anti-oxidant, antitumor, anti- platelet aggregation, hypotensive, hypoglycemic & hypolipidemic properties.

   • According to Mansi Kamal (2009)

     Excerpt The results have given a considerable agreement to the traditional use of AG in the treatment of hyperlipidemia; it could possibly lead to appropriate changes in blood lipid profiles.

   • According to Ahmed QS (2012)

     Excerpt The present study was carried out to explore protective effects of ethanolic extract of Apium graveolens (celery seeds) on Ritonavir, a protease inhibitor induced dyslipidemia. Conclusion: Above results suggest that ethanolic extract of AG seeds possess potential for improving blood lipid profile & liver lipids deranged by Ritonavir when given concurrently.

3. 3

   Adjuvant treatment for prostate, oral, brain, uterine and colorectal cancer, as well as melanoma and rhabdomyosarcoma

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lyer D (2019)

     Excerpt Tumor regression studies showed a regression response for tumor growth in vivo of murine mouse melanoma tumor cell lines. The animals were observed for the growth of tumor after injection of B16F10 melanoma cells into the dorsal skin of mice.

   • According to SHARMA V (2008)

     Excerpt Ethanolic extract of seeds of Apium graveolens showed a remarkable in vitro cytotoxicity against four human cancer cell lines of colon, CNS, oral & cervical origin. Results revealed that the most significant cytotoxic effect was observed in case of chloroform soluble & n-butanol soluble fractions as both inhibited the growth of eight human cancer cell lines of lung, liver, colon, CNS & ovarian origin.

   • According to Hussein EM (2007)

     Excerpt Present study was designed to evaluate anticancer effect of Apium graveolens seed extracts (aqueous, ethanolic & hexane extracts) in vitro on two cell lines (RD & L20B) using different concentrations of A. The results revealed a clear cytotoxic activity of those extracts on growth of RD cancer cell line, & the effect was concentration-dependent.

   • According to Köken T (2016)

     Excerpt Apium graveolens has been shown to inhibit the growth of a variety of cancer tissues. graveolens on the human prostatic carcinoma cell line LNCaP.

   • According to AL-Jumaily RKM (2010)

     Excerpt Present study was designed to evaluate anticancer effect of Apium graveolens seed extracts (aqueous, ethanolic & hexane extracts) in vitro on two cell lines (RD & L20B) using different concentrations of A. The results revealed a clear cytotoxic activity of those extracts on growth of RD cancer cell line, & the effect was concentration-dependent.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.