Areca catechu (Arékié) : medicinal properties in alcoholic extraction

Areca catechu (Arékié, Arequier) — family Arecacées.

Scientific synonyms : Areca catechu-Burm.f, A macrocarpa-C ex M.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 24 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 98 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sahane RS (2013)

     Excerpt The present study was done to evaluate the ethanolic extract of Areca catechu leaves for antidiabetic activity in Sprague Dawley rats. Diabetes mellitus was induced in rats by High fat diet, high fat emulsion & intraperitoneal injection of Streptozotocin (STZ, 35mg/kg body weight).

   • According to Song F (2022)

     Excerpt This study focused on the flavonoid compounds of arecanut & their in vitro bioactivities, including antioxidant activities and inhibitory potential towards enzymes involved in the treatment of hyperglycemia & hypertension. Furthermore, ultra-high-performance liquid chromatography coupled with mass spectrometry(UHPLC–MS/MS) was utilized to characterize the flavonoidcompositions in extracts of areca nut.

   • According to Mondal S (2012)

     Excerpt Diabetes mellitus was induced in rats by single intraperitoneal injection of streptozotocin (STZ, 50 mg/kg body weight). Areca catechu commonly known as Areca nut in English, is a perennial tree occurring throughout the Indian subcontinent & used traditionally for several medicinal purposes.

   • According to Ghate R (2014)

     Excerpt catechu flowers were administrated orally at the dose of 500 mg/kg for hypoglycemic effect in alloxan induced diabetic rats for 21 d. catechu flowers have shown a significant antidiabetic efficacy in alloxan induced diabetic rats.

   • According to Balkrishna A (2023)

     Excerpt Some common herbal remedies, including Foeniculum vulgare, Tinospora cordifolia, Asparagus racemosus, Ocimum tenuiflorum, Areca catechu, & Lepidium meyenii, have been highly regarded sources that have the benefits of lowering PCOS as well as having hypoglycemic & antiobesity effects. PCOS is linked to obesity, insulin resistance, & increased amounts of androgens, or male hormones.

2. 2

   Cancer: adjuvant treatment of breast cancer and oral squamous cell carcinoma

   Plant part used: seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sari ML (2017)

     Excerpt This study was undertaken to assess the anticancer potential of areca nut extract on human squamous carcinoma (HSC)-3, HSC-2 & human keratinocyte (HaCat) cancer cell lines, and to elucidate the mechanism of its action. Areca (betel, Areca catechu) nuts have been reported to show high contents of phenolic and flavonoid compounds with associated antioxidant activity.

   • According to Lakshmi T (2017)

     Excerpt catechu seed (ACS) against SCC-25 human oral squamous carcinoma cell line. Conclusion:The ethanol seed extracts of AC was found to be cytotoxic at lower concentrations & induced apoptosis in human oral squamous carcinoma SCC-25 cells.

   • According to Meiyanto E (2003)

     Excerpt This research therefore addressed to examine the inhibitory effect of Areca catechu seed ethanolic extract (EP) on proliferating breast cancer cells, MCF-7. These results conclude that Areca catechu seed ethanolic extract (EP) possesses antiproliferative effect through growth inhibition & apoptosis induction.

   • According to BHAT JG (2023)

     Excerpt With this information, we formulated a polyherbal preparation chiefly containing these two plant products & evaluated its anticancer efficacy on the specific cancer cell line. It was screened for its anticancer properties against A549 cancer cell lines.

   • According to Meiyanto E (2009)

     Excerpt Previous study on cytotoxic activity of Areca catechu L. on human colon cancer WiDr cells showed that the IC50 values of AC ethanolic extract (AE) & AC chloroform fraction (ACF) were 124 µg/mL & 119 µg/mL respectively.

3. 3

   High blood pressure, oedema

   Plant part used: seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to BHANDARE AM (2010)

     Excerpt The hydroalcoholic extract of Areca catechu L. Altogether, these results suggest that the hydroalcoholic extract of AC could be considered as a potential analgesic, anti-inflammatory & antioxidant agent.

   • According to Anthikat RRN (2012)

     Excerpt Objective: To explore the Anti-inflammatory activity of aqueous extract of A catechu L in carrageenan, dextran & formalin induced inflammation models in Swiss albino mice, by injection into the interdigital area, through the subplantar region of the paw. Results: The present investigation provides proof for the effectiveness of treatment as an anti-inflammatory and antioxidant agent.

   • According to SARTINA A (2022)

     Excerpt The objective of this review is to collect information about the Arecaceae family as anti-OA agents, with the main study focusing on the primary & secondary metabolites of plants of the Arecaceae family, i.e., sugar palm (Arenga pinnata), nipa palm (Nypa fruticans), palmyra palm (Borassus flabellifer), date palm (Phoenix dactylifera), & betel nut (Areca catechu) have potential as anti-OA agents. The Aceraceae’s metabolites that show anti-inflammatory & chondroprotective effects are galactomannan, fatty acids (linoleic and linolenic acids), flavonoids (quercetin, luteolin, isorhamnetin), phenolics (coumaric acid, ferulic acid), polyphenols (epicatechin), & steroids (stigmasterol, campesterol, spirostane).

   • According to Lee KP (2014)

     Excerpt The anti-inflammatory effect of Indonesian Areca catechu leaf extract in vitro & in vivo.

   • According to Sharafudheen J (2015)

     Excerpt Sharafudheen J et al, Anti-inflammatory & antinociceptive activities of areca nut water extract.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.