Artemisia dracunculus (Wild thyme) : medicinal properties in alcoholic extraction

Artemisia dracunculus (Wild thyme, Serpolet) — family Astéracées.

Scientific synonyms : Achillea dracunculus Hort. ex Steud., A aromatica A. Nelson, A changaica Krasch., Artemisia dracunculoides Pursh, A glauca Pall. ex Willd., A inodora Hook. &. Am., A nodora Willd., Oligosporus dracunculiformis (Karsch.) Poljaov, O dracunculus (L.) Poljakod. &. Am, O glaucus (Pall. ex Willd.) Poljaov..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 79 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Normalisation of serum parameters: Bilirubin, ALP, ALT, ASP, MDA, SOT, CAT, GST & GSH

   Plant part used: Aerial_parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Zare Vahid (2018)

     Excerpt The present study was conducted to investigate the antioxidant and hepatoprotective activity of the hydro-alcoholic extract of aerial parts of Artemisia dracunculus (HAAD) against CCl4-induced hepatotoxicity in rats. Hepatoprotective effects were investigated by assessment of serum biochemical enzymes such as alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total protein (TP), total bilirubin (TB), malondialdehyde (MDA), & antioxidant enzymes (SOD, CAT, GST & GSH), along with histopathological studies.

   • According to Kalantari H (2013)

     Excerpt Mutagenicity & liver toxicity of the herb tarragon (Artemisia dracunculus) was evaluated using single cell gel (comet) electrophoresis. The in vivo liver toxicity of AD was assessed in the blood of mice treated orally with the extract of the herb, using alanine aminotransferase (ALT) & aspartate aminotransferase (AST) as liver function indicators.

   • According to Obolskiy D (2011)

     Excerpt Artemisia dracunculus L. In vivo studies mainly in rodents, particularly from Russian sources, highlight potential anti-inflammatory, hepatoprotective, & antihyperglycemic effects.

   • According to Ticolea M (2024)

     Excerpt The antioxidant activity of the extracts was evaluated in vitro by DPPH, FRAP, H2O2, & NO scavenging tests & in vivo by measuring the total oxidative status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), 8-hydroxy-deoxyguanosine (8-Oxo-dG), advanced oxidation protein products (AOPP), malondialdehyde (MDA), nitric oxide (NO), 3-nitrotyrosine (3NT), & total thiols (SH). This study aimed to investigate the antioxidant & anti-inflammatory activities mechanism of Artemisia dracunculus (A.

   • According to Wang ZQ (2008)

     Excerpt An alcoholic extract of Artemisia dracunculus L (PMI 5011) has been shown to decrease glucose & improve insulin levels in animal models, suggesting an ability to enhance insulin sensitivity.

2. 2

   Type II diabetes mellitus

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Yu Y (2019)

     Excerpt DMC-2), from the mixture of phytochemicals in an ethanol extract from Artemisia dracunculus to determine to what degree the more abundant 2 accounts for the established antidiabetic effect of the AD extract. Using an otherwise chemically intact "knock-out extract" depleted in 2 & its regioisomer, 1, in vitro & in vivo outcomes confirmed that 2 (& likely 1) acts as major bioactive(s) that enhance(s) insulin signaling in skeletal muscle, but also revealed that 2 does not account for the breadth of detectable biological activity of the extract.

   • According to Wang ZQ (2008)

     Excerpt We measured basal & insulin-stimulated glucose uptake, glycogen accumulation, phosphoinositide 3 (PI-3) kinase activity, & Akt phosphorylation in primary skeletal muscle culture from subjects with type 2 diabetes mellitus incubated with or without various concentrations of PMI 5011. An alcoholic extract of Artemisia dracunculus L (PMI 5011) has been shown to decrease glucose & improve insulin levels in animal models, suggesting an ability to enhance insulin sensitivity.

   • According to Author (2016)

     Excerpt Preliminary data from our laboratory suggests that PMI-5011 may have significant effects to improve carbohydrate metabolism by enhancing molecular events of insulin action in skeletal muscle.PMI-5011 is an herbal botanical dietary supplement prepared from Artemisia dracunculus L. The AD extract described in this project as PMI-5011 was originally identified from a screening of extracts for hypoglycemic activity in diabetic mice as the most promising candidate for the development of a nutritional supplement for diabetes.

   • According to Kirk-Ballard H (2014)

     Excerpt An extract from Artemisia dracunculus, termed PMI 5011, improves insulin signaling & increases skeletal muscle myofiber size in a rodent model of obesity-related insulin resistance. Obesity is linked to insulin resistance, a primary component of metabolic syndrome & type 2 diabetes.

   • According to Ribnicky DM (2009)

     Excerpt (PMI-5011) was shown to be hypoglycemic in animal models for Type 2 diabetes & contains at least 6 bioactive compounds responsible for its anti-diabetic properties. At doses of 50-500mg/kg/day, the hypoglycemic activity of the extract was enhanced 3-5-fold with the bioenhancer Labrasol, making it comparable to the activity of the anti-diabetic drug metformin.

3. 3

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Yu Y (2019)

     Excerpt DMC-2), from the mixture of phytochemicals in an ethanol extract from Artemisia dracunculus to determine to what degree the more abundant 2 accounts for the established antidiabetic effect of the AD extract. Using an otherwise chemically intact "knock-out extract" depleted in 2 & its regioisomer, 1, in vitro & in vivo outcomes confirmed that 2 (& likely 1) acts as major bioactive(s) that enhance(s) insulin signaling in skeletal muscle, but also revealed that 2 does not account for the breadth of detectable biological activity of the extract.

   • According to Wang ZQ (2008)

     Excerpt We measured basal & insulin-stimulated glucose uptake, glycogen accumulation, phosphoinositide 3 (PI-3) kinase activity, & Akt phosphorylation in primary skeletal muscle culture from subjects with type 2 diabetes mellitus incubated with or without various concentrations of PMI 5011. An alcoholic extract of Artemisia dracunculus L (PMI 5011) has been shown to decrease glucose & improve insulin levels in animal models, suggesting an ability to enhance insulin sensitivity.

   • According to Author (2016)

     Excerpt Preliminary data from our laboratory suggests that PMI-5011 may have significant effects to improve carbohydrate metabolism by enhancing molecular events of insulin action in skeletal muscle.PMI-5011 is an herbal botanical dietary supplement prepared from Artemisia dracunculus L. The AD extract described in this project as PMI-5011 was originally identified from a screening of extracts for hypoglycemic activity in diabetic mice as the most promising candidate for the development of a nutritional supplement for diabetes.

   • According to Kirk-Ballard H (2014)

     Excerpt An extract from Artemisia dracunculus, termed PMI 5011, improves insulin signaling & increases skeletal muscle myofiber size in a rodent model of obesity-related insulin resistance. Obesity is linked to insulin resistance, a primary component of metabolic syndrome & type 2 diabetes.

   • According to Ribnicky DM (2009)

     Excerpt (PMI-5011) was shown to be hypoglycemic in animal models for Type 2 diabetes & contains at least 6 bioactive compounds responsible for its anti-diabetic properties. At doses of 50-500mg/kg/day, the hypoglycemic activity of the extract was enhanced 3-5-fold with the bioenhancer Labrasol, making it comparable to the activity of the anti-diabetic drug metformin.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.