Artemisia dracunculus (Serpolet) : propiedades medicinales en extracción alcohólica

Artemisia dracunculus (Serpolet, Wild thyme) — familia Astéracées.

Sinónimos científicos : Achillea dracunculus Hort. ex Steud., A aromatica A. Nelson, A changaica Krasch., Artemisia dracunculoides Pursh, A glauca Pall. ex Willd., A inodora Hook. &. Am., A nodora Willd., Oligosporus dracunculiformis (Karsch.) Poljaov, O dracunculus (L.) Poljakod. &. Am, O glaucus (Pall. ex Willd.) Poljaov..

Esta base documenta las extracciones alcohólicas (etanol) de las sustancias activas. Nuestra monografía recoge actualmente 10 indicaciones en extracción alcohólica para esta especie. El catálogo Lapo v2 registra 79 referencias científicas para esta especie (detalle completo en la aplicación).

Indicaciones terapéuticas en extracción alcohólica:

Importante — referencias científicas en esta página pública: solo se muestra un breve extracto de cada fuente citada (frases de resumen seleccionadas), conservado en el idioma original de la publicación (casi siempre el inglés), sin traducir. Estos extractos no constituyen el texto íntegro del artículo ni una bibliografía completa. Las fichas de referencia completas y el detalle monográfico están disponibles en la aplicación Lapo v2 (prueba gratuita de 30 días).

1. 1

   Normalización de los parámetros séricos: bilirrubina, ALP, ALT, ASP, MDA, SOT, CAT, GST y GSH

   Parte usada: Partes aéreas.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Zare Vahid (2018)

     Extrait Hepatoprotective effects were investigated by assessment of serum biochemical enzymes such as alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total protein (TP), total bilirubin (TB), malondialdehyde (MDA), & antioxidant enzymes (SOD, CAT, GST & GSH), along with histopathological studies. The present study was conducted to investigate the antioxidant and hepatoprotective activity of the hydro-alcoholic extract of aerial parts of Artemisia dracunculus (HAAD) against CCl4-induced hepatotoxicity in rats.

   • Selon Kalantari H (2013)

     Extrait Mutagenicity & liver toxicity of the herb tarragon (Artemisia dracunculus) was evaluated using single cell gel (comet) electrophoresis. The in vivo liver toxicity of AD was assessed in the blood of mice treated orally with the extract of the herb, using alanine aminotransferase (ALT) & aspartate aminotransferase (AST) as liver function indicators.

   • Selon Obolskiy D (2011)

     Extrait Artemisia dracunculus L. In vivo studies mainly in rodents, particularly from Russian sources, highlight potential anti-inflammatory, hepatoprotective, & antihyperglycemic effects.

   • Selon Ticolea M (2024)

     Extrait The antioxidant activity of the extracts was evaluated in vitro by DPPH, FRAP, H2O2, & NO scavenging tests & in vivo by measuring the total oxidative status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), 8-hydroxy-deoxyguanosine (8-Oxo-dG), advanced oxidation protein products (AOPP), malondialdehyde (MDA), nitric oxide (NO), 3-nitrotyrosine (3NT), & total thiols (SH). This study aimed to investigate the antioxidant & anti-inflammatory activities mechanism of Artemisia dracunculus (A.

   • Selon Wang ZQ (2008)

     Extrait An alcoholic extract of Artemisia dracunculus L (PMI 5011) has been shown to decrease glucose & improve insulin levels in animal models, suggesting an ability to enhance insulin sensitivity.

2. 2

   Diabetes mellitus tipo II

   Parte usada: raíz.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Yu Y (2019)

     Extrait DMC-2), from the mixture of phytochemicals in an ethanol extract from Artemisia dracunculus to determine to what degree the more abundant 2 accounts for the established antidiabetic effect of the AD extract. Using an otherwise chemically intact "knock-out extract" depleted in 2 & its regioisomer, 1, in vitro & in vivo outcomes confirmed that 2 (& likely 1) acts as major bioactive(s) that enhance(s) insulin signaling in skeletal muscle, but also revealed that 2 does not account for the breadth of detectable biological activity of the extract.

   • Selon Wang ZQ (2008)

     Extrait We measured basal & insulin-stimulated glucose uptake, glycogen accumulation, phosphoinositide 3 (PI-3) kinase activity, & Akt phosphorylation in primary skeletal muscle culture from subjects with type 2 diabetes mellitus incubated with or without various concentrations of PMI 5011. An alcoholic extract of Artemisia dracunculus L (PMI 5011) has been shown to decrease glucose & improve insulin levels in animal models, suggesting an ability to enhance insulin sensitivity.

   • Selon Auteur (2016)

     Extrait Preliminary data from our laboratory suggests that PMI-5011 may have significant effects to improve carbohydrate metabolism by enhancing molecular events of insulin action in skeletal muscle.PMI-5011 is an herbal botanical dietary supplement prepared from Artemisia dracunculus L. The AD extract described in this project as PMI-5011 was originally identified from a screening of extracts for hypoglycemic activity in diabetic mice as the most promising candidate for the development of a nutritional supplement for diabetes.

   • Selon Kirk-Ballard H (2014)

     Extrait An extract from Artemisia dracunculus, termed PMI 5011, improves insulin signaling & increases skeletal muscle myofiber size in a rodent model of obesity-related insulin resistance. Obesity is linked to insulin resistance, a primary component of metabolic syndrome & type 2 diabetes.

   • Selon Ribnicky DM (2009)

     Extrait (PMI-5011) was shown to be hypoglycemic in animal models for Type 2 diabetes & contains at least 6 bioactive compounds responsible for its anti-diabetic properties. At doses of 50-500mg/kg/day, the hypoglycemic activity of the extract was enhanced 3-5-fold with the bioenhancer Labrasol, making it comparable to the activity of the anti-diabetic drug metformin.

3. 3

   Diabetes mellitus tipo II

   Parte usada: semilla.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Yu Y (2019)

     Extrait DMC-2), from the mixture of phytochemicals in an ethanol extract from Artemisia dracunculus to determine to what degree the more abundant 2 accounts for the established antidiabetic effect of the AD extract. Using an otherwise chemically intact "knock-out extract" depleted in 2 & its regioisomer, 1, in vitro & in vivo outcomes confirmed that 2 (& likely 1) acts as major bioactive(s) that enhance(s) insulin signaling in skeletal muscle, but also revealed that 2 does not account for the breadth of detectable biological activity of the extract.

   • Selon Wang ZQ (2008)

     Extrait We measured basal & insulin-stimulated glucose uptake, glycogen accumulation, phosphoinositide 3 (PI-3) kinase activity, & Akt phosphorylation in primary skeletal muscle culture from subjects with type 2 diabetes mellitus incubated with or without various concentrations of PMI 5011. An alcoholic extract of Artemisia dracunculus L (PMI 5011) has been shown to decrease glucose & improve insulin levels in animal models, suggesting an ability to enhance insulin sensitivity.

   • Selon Auteur (2016)

     Extrait Preliminary data from our laboratory suggests that PMI-5011 may have significant effects to improve carbohydrate metabolism by enhancing molecular events of insulin action in skeletal muscle.PMI-5011 is an herbal botanical dietary supplement prepared from Artemisia dracunculus L. The AD extract described in this project as PMI-5011 was originally identified from a screening of extracts for hypoglycemic activity in diabetic mice as the most promising candidate for the development of a nutritional supplement for diabetes.

   • Selon Kirk-Ballard H (2014)

     Extrait An extract from Artemisia dracunculus, termed PMI 5011, improves insulin signaling & increases skeletal muscle myofiber size in a rodent model of obesity-related insulin resistance. Obesity is linked to insulin resistance, a primary component of metabolic syndrome & type 2 diabetes.

   • Selon Ribnicky DM (2009)

     Extrait (PMI-5011) was shown to be hypoglycemic in animal models for Type 2 diabetes & contains at least 6 bioactive compounds responsible for its anti-diabetic properties. At doses of 50-500mg/kg/day, the hypoglycemic activity of the extract was enhanced 3-5-fold with the bioenhancer Labrasol, making it comparable to the activity of the anti-diabetic drug metformin.

Otras indicaciones (incluidos otros modos de extracción si procede), posologías, precauciones de uso y las <strong>referencias científicas completas</strong> (fichas íntegras, no solo los extractos cortos anteriores) están disponibles en la ficha monográfica de la aplicación Lapo v2.