Artocarpus altilis (Fouyapen) : medicinal properties in alcoholic extraction

Artocarpus altilis (Fouyapen, Breadfruit, Fruit-à-pain) — family Moracées.

Scientific synonyms : Artocarpus communis-TR & G.F, A. incisa-(T)-L. f, var. N.s. Duss, Sitodium Altile Parkinson.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 34 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of colorectal, breast, lung, liver, uterine, bladder, brain, stomach, kidney, prostate and pancreatic cancer

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hsu (2010)

     Excerpt Cytotoxic effects of geranyl flavonoid derivatives from the fruit of Artocarpus communis in SK-Hep-1 human hepatocellular Carcinoma, Food Chem.

   • According to Juliastuti H (2017)

     Excerpt Breadfruit leaf (Artocarpus altilis) can be used to cure several diseases such as renal disease, high blood pressure, liver, diabetes, asthma, toothache, skin infection and cancer in Indonesian community. This study was aimed to examine the hepatoprotective effect of ethanol extract of Indonesian breadfruit leaf in carbon tetrachloride-induced liver injury Wistar rats by measuring Serum Glutamic Pyruvic Transaminase (SGPT) & Malondialdehyde (MDA) levels.

   • According to WAHYUDIN M (2017)

     Excerpt Artocarpus altilis plants have traditionally been used by the people of Indonesia for the treatment of diabetes mellitus. altilis leaf extract that can improve insulin resistance in obese rats (Rattus norvegicus) through identification of the concentrations that can decrease the levels of FFA.

   • According to Arung TE (2009)

     Excerpt Anticancer Properties of Diethyether Extract of Wood from Sukun (Artocarpus altilis) in Human Breast Cancer (T47D) Cells, Trop J of Pharmaceut Res, 2009, 8(4) 317-24.

   • According to Palupi (2020)

     Excerpt This study aimed to evaluate the anti-inflammatory, antioxidant, & immunomodulatory of ethanolic extract of the leaf, fruit, & bark from Artocarpus altilis which is traditionally used for the treatment of inflammation-related diseases. Ethanolic extract of these compounds at 100 & 200 mg/kg doses was orally administered in chronic inflammatory rats induced by Freund's Complete Adjuvant for 14 days to investigate there in vivo anti-inflammatory & antioxidant activity.

2. 2

   Type I and Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Puspa DN (2014)

     Excerpt Enzyme α-glucosidase inhibition assay of Artocarpus altilis leaf extract shown that ethanol extract, ethyl acetate fraction & two flavonoid compounds (AC-31 & AC-51) have antidiabetic activity stronger than quercetin as positive control with IC50 value 6.79 μg/mL, 5.98 μg/mL, 15.73 μM, & 24.41 μM, respectively.

   • According to METHI Indravati (n.d.)

     Excerpt altilis leaves decoction and GABA on blood glucose levels and insulin expression of bêta-cells in streptozotocin-induced diabetic rats. Information about the Artocarpus altilis leaf as an antidiabetic associated with the active compounds Gamma Amino Butyric Acid (GABA) is still limited.

   • According to WAHYUDIN M (2017)

     Excerpt Artocarpus altilis plants have traditionally been used by the people of Indonesia for the treatment of diabetes mellitus. altilis leaf extract that can improve insulin resistance in obese rats (Rattus norvegicus) through identification of the concentrations that can decrease the levels of FFA.

   • According to Vienna S (2015)

     Excerpt Altilis, one of its major bioactive constituents, has a broad range of pharmacological activity such as antioxidant, antibacterial, anti-inflammatory, antidiabetic & many others. Artocarpus altilis is one kind of herbal medicine that is usually used by Indonesian people.

   • According to Juliastuti H (2017)

     Excerpt Breadfruit leaf (Artocarpus altilis) can be used to cure several diseases such as renal disease, high blood pressure, liver, diabetes, asthma, toothache, skin infection and cancer in Indonesian community.

3. 3

   Hepatitis, normalisation of liver function tests (MDA & SGPT)

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Juliastuti H (2017)

     Excerpt Breadfruit leaf (Artocarpus altilis) can be used to cure several diseases such as renal disease, high blood pressure, liver, diabetes, asthma, toothache, skin infection and cancer in Indonesian community. This study was aimed to examine the hepatoprotective effect of ethanol extract of Indonesian breadfruit leaf in carbon tetrachloride-induced liver injury Wistar rats by measuring Serum Glutamic Pyruvic Transaminase (SGPT) & Malondialdehyde (MDA) levels.

   • According to Hsu (2010)

     Excerpt Cytotoxic effects of geranyl flavonoid derivatives from the fruit of Artocarpus communis in SK-Hep-1 human hepatocellular Carcinoma, Food Chem.

   • According to WAHYUDIN M (2017)

     Excerpt The fasting blood sugar (GDP) was monitored through gluco DR tests to ensure that the mice exhibited an increased glucose concentration. Artocarpus altilis plants have traditionally been used by the people of Indonesia for the treatment of diabetes mellitus.

   • According to Palupi (2020)

     Excerpt This study aimed to evaluate the anti-inflammatory, antioxidant, & immunomodulatory of ethanolic extract of the leaf, fruit, & bark from Artocarpus altilis which is traditionally used for the treatment of inflammation-related diseases. The maximum percentage of inflammation, serum levels of peroxide radicals, & liver superoxide dismutase activity were observed, and in vitro antioxidant was measured by using the scavenging of nitric oxide & 2, 2-Diphenyl-1- picrylhydrazyl radicals’ methods.

   • According to Kingsley AI (2014)

     Excerpt Artocarpus altilis is used in ethnomedicine for the treatment of boils & wounds, hypertension, skin infections & in pain management. This study therefore evaluated the anti-inflammatory activity, as well as the antioxidant potential of an ethanol stem bark extract of A altilis.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.