Asparagus racemosus (Mouslinn’) : medicinal properties in alcoholic extraction

Asparagus racemosus (Mouslinn’, Mousseline, Shatavari (India), Shatavari (Inde)) — family Asparagacées.

Scientific synonyms : Asparagus rigidulus-Nakal, Protasparagus racemosus-(Willd)-Oberm.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 19 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 145 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Nephrotoxicity in people with diabetes

   Plant part used: root. Mentioned synergistic association: association synergique avec PLUMERIA RUBRA-L (Fleur), Centella asiatica-feuille.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Yadav AV (2022)

     Excerpt The current investigation analysed the effect of combination of standardized hydroalcoholic extracts of Asparagus racemosus (AR), Centella asiatica (CA) & Plumeria rubra (PR) on Glibenclamide (GB) administered in experimentally induced diabetic nephropathy (DN) in Wistar rats. Co-administration of ACP (400mg/kg) with GB (5mg/kg) significantly (p<0.01) decreased BUN, creatinine, uric acid, significantly increased (p<0.05) SOD, significantly (p<0.01) decreased MDA, significantly increased (p<0.05) serum insulin when compared with diabetic control.

   • According to Pandey AR (2022)

     Excerpt Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol saponins, furoasparoside A-F along with five known compounds, gallic acid, methyl gallate, quercetin-3-O-β-glucopyranoside, liquiritigenin 4׳-O-β-apiofuranosyl-(1 → 2)-β-glucopyranoside & β-glucogallin for the first time from the roots of Asparagus racemosus. Isolated saponins were screened for their antidiabetic potential in L6-GLUT 4mycmyotubes in vitro followed by an in vivo evaluation in streptozocin-induced diabetic rats & db/db mice.

   • According to Chaudhary D (2023)

     Excerpt Asparagus racemosus commonly known as Shatavari or Kurilo is a spinous shrub with tuberous roots found commonly in the tropical and subtropical regions of Nepal, India, Australia, & Africa. It is a well-known plant in Ayurveda, Siddha, Unani, & other traditional system of medicines for the treatment of various ailments, including dyspepsia, bleeding and nervous disorders, cough, jaundice, diabetes, to promote lactation, tonic, etc.

   • According to Choudhary B (2020)

     Excerpt The whole study was designed to find out probable anti-diabetic potential of various phytoconstituents of Glycyrrhiza glabra & Asparagus racemosus. The study was further aimed at correlating the relationship between various phytoconstituents of both plants with major receptors playing an important role in diabetes mellitus by in silico & in vitro techniques.

   • According to Hannan JM (2007)

     Excerpt Asparagus racemosus root has previously been reported to reduce blood glucose in rats & rabbits. The ethanol extract & each of the hexane, chloroform & ethyl acetate partition fractions concentration-dependently stimulated insulin secretion in isolated perfused rat pancreas, isolated rat islet cells & clonal beta-cells.

2. 2

   Type II diabetes mellitus

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pandey AR (2022)

     Excerpt Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol saponins, furoasparoside A-F along with five known compounds, gallic acid, methyl gallate, quercetin-3-O-β-glucopyranoside, liquiritigenin 4׳-O-β-apiofuranosyl-(1 → 2)-β-glucopyranoside & β-glucogallin for the first time from the roots of Asparagus racemosus. Isolated saponins were screened for their antidiabetic potential in L6-GLUT 4mycmyotubes in vitro followed by an in vivo evaluation in streptozocin-induced diabetic rats & db/db mice.

   • According to Chaudhary D (2023)

     Excerpt Asparagus racemosus commonly known as Shatavari or Kurilo is a spinous shrub with tuberous roots found commonly in the tropical and subtropical regions of Nepal, India, Australia, & Africa. It is a well-known plant in Ayurveda, Siddha, Unani, & other traditional system of medicines for the treatment of various ailments, including dyspepsia, bleeding and nervous disorders, cough, jaundice, diabetes, to promote lactation, tonic, etc.

   • According to Yadav AV (2022)

     Excerpt The current investigation analysed the effect of combination of standardized hydroalcoholic extracts of Asparagus racemosus (AR), Centella asiatica (CA) & Plumeria rubra (PR) on Glibenclamide (GB) administered in experimentally induced diabetic nephropathy (DN) in Wistar rats. Co-administration of ACP (400mg/kg) with GB (5mg/kg) significantly (p<0.01) decreased BUN, creatinine, uric acid, significantly increased (p<0.05) SOD, significantly (p<0.01) decreased MDA, significantly increased (p<0.05) serum insulin when compared with diabetic control.

   • According to Choudhary B (2020)

     Excerpt The whole study was designed to find out probable anti-diabetic potential of various phytoconstituents of Glycyrrhiza glabra & Asparagus racemosus. The study was further aimed at correlating the relationship between various phytoconstituents of both plants with major receptors playing an important role in diabetes mellitus by in silico & in vitro techniques.

   • According to Hannan JM (2007)

     Excerpt Asparagus racemosus root has previously been reported to reduce blood glucose in rats & rabbits. The ethanol extract & each of the hexane, chloroform & ethyl acetate partition fractions concentration-dependently stimulated insulin secretion in isolated perfused rat pancreas, isolated rat islet cells & clonal beta-cells.

3. 3

   Adjuvant treatment for epithelional lung carcinoma

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mitra SK (2012)

     Excerpt The anticancer activity of shatavarins (containing Shatavarin IV) isolated from the roots of Asparagus racemosus (Wild) was evaluated using in vitro & in vivo experimental models. The in vivo anticancer activity of shatavarins (containing Shatavarin IV) was evaluated against Ehrlich ascites carcinoma (EAC) tumor bearing mice.

   • According to Kabir SR (2021)

     Excerpt A lectin (designated as ARL) was purified first time from the Asparagus racemosus root with the molecular weight of 14.0 kDa containing about 4.8% carbohydrate. Around 48% & 52.5% human colorectal cancer (HCT-116) cells growth was inhibited by 160 μg/ml of ARL and 256 μg/ml of previously purified Geodorum densiflorum rhizome lectin (GDL).

   • According to Liang H (2022)

     Excerpt The anti-tumor effect of ASP has been studied in hepatocellular carcinoma. The PPI network identified tumor protein 53 (TP53), Fo’s proto-oncogene, AP-1 transcription factor subunit (FOS), & AKT serine/threonine kinase 1 (AKT1) as key targets.

   • According to Ji Y (2012)

     Excerpt Conclusions: Asparagus saponins induce apoptosis in HepG2 cells through a mitochondrial-mediated & caspase-dependent pathway, suggesting that they may be a potent agent for the treatment of hepatocellular carcinoma. We investigated the effects of saponins isolated from Asparagus on proliferation & apoptosis in the human hepatoma cell line HepG2., Methods: HepG2 cells were treated with varying concentrations of Asparagus saponins at various times.

   • According to Bhutani KK (2018)

     Excerpt A series of Sarsapogenin & Diosgenin derived steroidal constituents (1-12), isolated from Solanum xanthocarpum & Asparagus racemosus were screened for their ability to induce cell death & apoptosis of colon carcinoma cells.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.