Asparagus racemosus (Mouslinn’) : vertus médicinales en extraction alcoolique

Asparagus racemosus (Mouslinn’, Mousseline, Shatavari (Inde), Shatavari (India)) — famille Asparagacées.

Synonymes scientifiques : Asparagus rigidulus-Nakal, Protasparagus racemosus-(Willd)-Oberm.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 19 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 145 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Néphrotoxicité du diabétique

   Partie usitée : Racine. Association synergique mentionnée : Plumeria Rubra-fleur, Centella asiatica-feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Yadav AV (2022)

     Extrait The current investigation analysed the effect of combination of standardized hydroalcoholic extracts of Asparagus racemosus (AR), Centella asiatica (CA) & Plumeria rubra (PR) on Glibenclamide (GB) administered in experimentally induced diabetic nephropathy (DN) in Wistar rats. Co-administration of ACP (400mg/kg) with GB (5mg/kg) significantly (p<0.01) decreased BUN, creatinine, uric acid, significantly increased (p<0.05) SOD, significantly (p<0.01) decreased MDA, significantly increased (p<0.05) serum insulin when compared with diabetic control.

   • Selon Pandey AR (2022)

     Extrait Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol saponins, furoasparoside A-F along with five known compounds, gallic acid, methyl gallate, quercetin-3-O-β-glucopyranoside, liquiritigenin 4׳-O-β-apiofuranosyl-(1 → 2)-β-glucopyranoside & β-glucogallin for the first time from the roots of Asparagus racemosus. Isolated saponins were screened for their antidiabetic potential in L6-GLUT 4mycmyotubes in vitro followed by an in vivo evaluation in streptozocin-induced diabetic rats & db/db mice.

   • Selon Chaudhary D (2023)

     Extrait Asparagus racemosus commonly known as Shatavari or Kurilo is a spinous shrub with tuberous roots found commonly in the tropical and subtropical regions of Nepal, India, Australia, & Africa. It is a well-known plant in Ayurveda, Siddha, Unani, & other traditional system of medicines for the treatment of various ailments, including dyspepsia, bleeding and nervous disorders, cough, jaundice, diabetes, to promote lactation, tonic, etc.

   • Selon Choudhary B (2020)

     Extrait The whole study was designed to find out probable anti-diabetic potential of various phytoconstituents of Glycyrrhiza glabra & Asparagus racemosus. The study was further aimed at correlating the relationship between various phytoconstituents of both plants with major receptors playing an important role in diabetes mellitus by in silico & in vitro techniques.

   • Selon Hannan JM (2007)

     Extrait Asparagus racemosus root has previously been reported to reduce blood glucose in rats & rabbits. The ethanol extract & each of the hexane, chloroform & ethyl acetate partition fractions concentration-dependently stimulated insulin secretion in isolated perfused rat pancreas, isolated rat islet cells & clonal beta-cells.

2. 2

   Diabète mellitus de type II

   Partie usitée : Racine. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Pandey AR (2022)

     Extrait Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol saponins, furoasparoside A-F along with five known compounds, gallic acid, methyl gallate, quercetin-3-O-β-glucopyranoside, liquiritigenin 4׳-O-β-apiofuranosyl-(1 → 2)-β-glucopyranoside & β-glucogallin for the first time from the roots of Asparagus racemosus. Isolated saponins were screened for their antidiabetic potential in L6-GLUT 4mycmyotubes in vitro followed by an in vivo evaluation in streptozocin-induced diabetic rats & db/db mice.

   • Selon Chaudhary D (2023)

     Extrait Asparagus racemosus commonly known as Shatavari or Kurilo is a spinous shrub with tuberous roots found commonly in the tropical and subtropical regions of Nepal, India, Australia, & Africa. It is a well-known plant in Ayurveda, Siddha, Unani, & other traditional system of medicines for the treatment of various ailments, including dyspepsia, bleeding and nervous disorders, cough, jaundice, diabetes, to promote lactation, tonic, etc.

   • Selon Yadav AV (2022)

     Extrait The current investigation analysed the effect of combination of standardized hydroalcoholic extracts of Asparagus racemosus (AR), Centella asiatica (CA) & Plumeria rubra (PR) on Glibenclamide (GB) administered in experimentally induced diabetic nephropathy (DN) in Wistar rats. Co-administration of ACP (400mg/kg) with GB (5mg/kg) significantly (p<0.01) decreased BUN, creatinine, uric acid, significantly increased (p<0.05) SOD, significantly (p<0.01) decreased MDA, significantly increased (p<0.05) serum insulin when compared with diabetic control.

   • Selon Choudhary B (2020)

     Extrait The whole study was designed to find out probable anti-diabetic potential of various phytoconstituents of Glycyrrhiza glabra & Asparagus racemosus. The study was further aimed at correlating the relationship between various phytoconstituents of both plants with major receptors playing an important role in diabetes mellitus by in silico & in vitro techniques.

   • Selon Hannan JM (2007)

     Extrait Asparagus racemosus root has previously been reported to reduce blood glucose in rats & rabbits. The ethanol extract & each of the hexane, chloroform & ethyl acetate partition fractions concentration-dependently stimulated insulin secretion in isolated perfused rat pancreas, isolated rat islet cells & clonal beta-cells.

3. 3

   Cancer traitement adjuvant du carcinome pulmonaire épithélial

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Mitra SK (2012)

     Extrait The anticancer activity of shatavarins (containing Shatavarin IV) isolated from the roots of Asparagus racemosus (Wild) was evaluated using in vitro & in vivo experimental models. The in vivo anticancer activity of shatavarins (containing Shatavarin IV) was evaluated against Ehrlich ascites carcinoma (EAC) tumor bearing mice.

   • Selon Kabir SR (2021)

     Extrait Around 48% & 52.5% human colorectal cancer (HCT-116) cells growth was inhibited by 160 μg/ml of ARL and 256 μg/ml of previously purified Geodorum densiflorum rhizome lectin (GDL). A lectin (designated as ARL) was purified first time from the Asparagus racemosus root with the molecular weight of 14.0 kDa containing about 4.8% carbohydrate.

   • Selon Liang H (2022)

     Extrait The anti-tumor effect of ASP has been studied in hepatocellular carcinoma. The PPI network identified tumor protein 53 (TP53), Fo’s proto-oncogene, AP-1 transcription factor subunit (FOS), & AKT serine/threonine kinase 1 (AKT1) as key targets.

   • Selon Ji Y (2012)

     Extrait Conclusions: Asparagus saponins induce apoptosis in HepG2 cells through a mitochondrial-mediated & caspase-dependent pathway, suggesting that they may be a potent agent for the treatment of hepatocellular carcinoma. We investigated the effects of saponins isolated from Asparagus on proliferation & apoptosis in the human hepatoma cell line HepG2., Methods: HepG2 cells were treated with varying concentrations of Asparagus saponins at various times.

   • Selon Bhutani KK (2018)

     Extrait A series of Sarsapogenin & Diosgenin derived steroidal constituents (1-12), isolated from Solanum xanthocarpum & Asparagus racemosus were screened for their ability to induce cell death & apoptosis of colon carcinoma cells.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.