Brassica oleracea (Chou-Ponmé) : medicinal properties in alcoholic extraction

Brassica oleracea (Chou-Ponmé, Red cabbage (var. Capitata), Broccoli (var. Italica), Kale (var. Sabellica), Brussels sprouts (var. gemmifera), Ornamental cabbage (var. acephala), Light green kohlrabi (var. Gongylodes), chou rouge (var Capitata), Brocoli (var Italica), Chou frisé(var Sabellica), Chou de Bruxelles(var gemmifera), Chou d’ornement (var acephala), Chou rave vert clair (var Gongylodes)) — family Brassicacées.

Scientific synonyms : Brassica oleracea subsp. Oleracea, B oleracea var. Capitata Linn, B oleracea L. var. sabellica.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 61 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Diabetic nephropathy

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kataya HA (2008)

     Excerpt Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss of body weight, hyperglycemia, polyuria, polydipsia, renal enlargement & renal dysfunction. In addition, BO extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione & superoxide dismutase activity as well as catalase activity & total antioxidant capacity of diabetic kidneys.

   • According to Cho EJ (2006)

     Excerpt Diabetic rats showed reduced body weight gain & heavier kidney & liver weights than normal rats, while oral administration of the BuOH fraction at an oral dose of 100 or 200 mg/kg body weight/d for 20 d attenuated the physiological changes induced by diabetes. The antioxidative effect & protective potential against diabetes of the broccoli flower were investigated both in vitro & in a diabetic rat model.

   • According to Shah MA (2016)

     Excerpt out of the three different doses viz., 200, 400 & 800 mg/kg body weight, the highest dose (800 mg/kg) caused a significant attenuation in the blood glucose at 180 min in Streptozotocin (STZ) induced diabetic rats when compared to the diabetic control group (P<0.001). Type 2 diabetes mellitus (T2DM) was induced in the SD rats with high fat diet & injecting a low dose (35 mg/kg) of streptozocin.

   • According to Assad T (2014)

     Excerpt The hypoglycemic & hypolipidemic effects of the methanol extract of Brassica oleracea var. RESULTS :The MEB revealed a decrease of 106.6 mg·dL−1 in fasting blood glucose as compared to diabetic control, which was almost comparable to glibenclamide; both of these changes were highly significant.

   • According to Kashan H (2017)

     Excerpt The second group (Diabetic group) received a single dose of alloxan (150 mg/kg BW i.p.) to induction of Diabetes mellitus type 2 (T2DM) while the third, fourth, & fifth groups were diabetic rats received 150, 300, 600 mg/kg, respectively, of BO ethanolic extracts orally for 60 days after induction of T2DM. The aim of this study was to investigate the effect of ethanolic extract of Brassica oleracea var.

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kataya HA (2008)

     Excerpt In addition, BO extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione & superoxide dismutase activity as well as catalase activity & total antioxidant capacity of diabetic kidneys. Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss of body weight, hyperglycemia, polyuria, polydipsia, renal enlargement & renal dysfunction.

   • According to Shah MA (2016)

     Excerpt out of the three different doses viz., 200, 400 & 800 mg/kg body weight, the highest dose (800 mg/kg) caused a significant attenuation in the blood glucose at 180 min in Streptozotocin (STZ) induced diabetic rats when compared to the diabetic control group (P<0.001). Type 2 diabetes mellitus (T2DM) was induced in the SD rats with high fat diet & injecting a low dose (35 mg/kg) of streptozocin.

   • According to Assad T (2014)

     Excerpt The hypoglycemic & hypolipidemic effects of the methanol extract of Brassica oleracea var. RESULTS :The MEB revealed a decrease of 106.6 mg·dL−1 in fasting blood glucose as compared to diabetic control, which was almost comparable to glibenclamide; both of these changes were highly significant.

   • According to Kashan H (2017)

     Excerpt The second group (Diabetic group) received a single dose of alloxan (150 mg/kg BW i.p.) to induction of Diabetes mellitus type 2 (T2DM) while the third, fourth, & fifth groups were diabetic rats received 150, 300, 600 mg/kg, respectively, of BO ethanolic extracts orally for 60 days after induction of T2DM. The aim of this study was to investigate the effect of ethanolic extract of Brassica oleracea var.

   • According to Cho EJ (2006)

     Excerpt Diabetic rats showed reduced body weight gain & heavier kidney & liver weights than normal rats, while oral administration of the BuOH fraction at an oral dose of 100 or 200 mg/kg body weight/d for 20 d attenuated the physiological changes induced by diabetes. The antioxidative effect & protective potential against diabetes of the broccoli flower were investigated both in vitro & in a diabetic rat model.

3. 3

   Liver disorders: normalisation of serum levels of AST, ALT, bilirubin, SGOT, SGPT, total cholesterol (TC), triglycerides (TG), HDL and LDL

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ahmed MF (2012)

     Excerpt There were significant changes were recorded in biochemical parameters i.e., increases in Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alanine Phosphatase (ALP), Serum bilirubin & decrease in Total proteins content & in oxidative stress markers such as GPx, GST, SOD & CAT, in simvastatin treated rats, which were restored towards normalization in BO var. The aim of this study was to investigate the hepatoprotective activities of Brassica oleracea L.

   • According to Ahmed MS (2013)

     Excerpt increases in Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alanine Phosphatase (ALP), Serum Bilirubin & decrease in Total proteins content, which were restored towards normalization in extracts treated rats. The present study deals with comparative evaluation of hepatoprotective activities of Melia azedarach Linn, Catharanthus Rosea & Brassica oleracea L.var.capitata ethanolic leaves extracts against simvastatin induced hepatotoxicity in rats.

   • According to Hamouda AF (2016)

     Excerpt The effect of AVOE (avocado), GE (Ginger) & CE (Cabbage) extracts separately on liver NO (nitric oxide), MDA (malondialdehyde), as well as serum AST (aspartate aminotransferase), ALT (alanine aminotransferase), total bilirubin, TC (total cholesterol), T.G (triglyceride), HDL cholesterol (high-density lipoprotein), LDL cholesterol (low-density lipoprotein), TSH (thyroid-stimulating hormone), T3 (Triiodothyronine), T4 (Thyroxine) in rats treated & untreated with CCl4 (carbon tetrachloride) was studied. The levels of NO, MDA, as well as serum AST, ALT, total bilirubin, TC, T.G, LDL, & TSH, showed an elevation while, HDL, T3 & T4 showed the decline in rats treated with CCl4 as compared to control.

   • According to Al-Howiriny T (n.d.)

     Excerpt CCl 4 induced hepatotoxicity in all treated animals was evident by elevated serum GOT, GPT, ALP, GGT and bilirubin levels and simultaneous fall in NP-SH and increased MDA activities in liver tissue. The BO extract at the doses of 150 & 300 mg/kg produced significant hepatoprotection by decreasing the activity of serum enzymes, bilirubin, while it significantly increased the levels of NP-SH & decreased MDA of liver tissue.

   • According to Cho EJ (2006)

     Excerpt Moreover, it significantly reduced Thiobarbituric acid-reactive substance levels in serum, hepatic & renal mitochondria. In addition, oral administration of the BuOH fraction to diabetic rats led to significant decreases in serum glucose & glycosylated protein, while it resulted in the increase of serum albumin, implying that the BuOH fraction improves the abnormal metabolism of glucose & protein that leads to oxidative stress.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.