Broussonetia papyrifera (The Three Wise Men) : medicinal properties in alcoholic extraction

Broussonetia papyrifera (The Three Wise Men, Chinese mulberry, Les 3 rois mages, Murier de Chine) — family Moracées.

Scientific synonyms : Morus papyrifera L., Papyrius papyrifera (L.) Kuntze.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 112 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Wang G.W. (2012)

     Excerpt Plants belonging to the genus Broussonetia (Moraceae), which grow naturally in Asian & Pacific countries, have long been used in traditional Chinese medicine to treat various conditions, particularly tinea, dysentery, hernia & oedema.

   • According to Lee JA (n.d.)

     Excerpt In this study, we investigated the effects of extracts of Broussonetia papyrifera root bark (PRE) & its bioactive components on inflammation & insulin sensitivity. The chronic low-grade inflammation in adipose tissue plays a causal role in obesity-induced insulin resistance & its associated pathophysiological consequences.

   • According to Author (2022)

     Excerpt The keywords for searching included “paper mulberry”, “Broussonetia papyrifera”, “skin-lightening”, “skin-whitening”, “depigmentation”, “pharmacological activity”, & “biological activity”. Apart from its anti-tyrosinase activity, paper mulberry and its compounds exhibited anti-inflammatory, antioxidant, antimicrobial, antiviral, anticancer, antidiabetic, anticholinesterase, antigout, antinociceptive, and hepatoprotective effects.

   • According to CHEN Y (2022)

     Excerpt The Broussonetia genus (Moraceae), recognized for its value in many Chinese traditional herbs, mainly includes Broussonetia papyrifera (L.) L'Hér. Moreover, its active compounds & extracts have exhibited a variety of pharmacological effects such as antitumor, antioxidant, anti-inflammatory, antidiabetic, anti-obesity, antibacterial, & antiviral properties, & its use against skin wrinkles.

   • According to Nguyen LTH (2022)

     Excerpt The keywords for searching included “paper mulberry”, “Broussonetia papyrifera”, “skin-lightening”, “skin-whitening”, “depigmentation”, “pharmacological activity”, & “biological activity”. Apart from its anti-tyrosinase activity, paper mulberry & its compounds exhibited anti-inflammatory, antioxidant, antimicrobial, antiviral, anticancer, antidiabetic, anticholinesterase, antigout, antinociceptive, & hepatoprotective effects.

2. 2

   Adjuvant treatment for liver cancer

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to SI B (2018)

     Excerpt This study was carried out to investigate the possible application of Broussonetia papyrifera (B. papyrifera) silage as a functional feeding stuff in dairy cattle.

   • According to XU B (2022)

     Excerpt This study aimed to evaluate the effects of Broussonetia papyrifera polysaccharide (BPP) on liver injury & intestinal flora induced by APAP. Overall, BPP was a potential hepatoprotective drug that could protect against APAP-induced liver injury & might be mediated by intestinal flora.

   • According to NIU K (2023)

     Excerpt The gene expression related to hepatic lipid metabolism including acetyl-CoA carboxylase, fatty acid synthase, & peroxisome proliferator-activated receptor (PPARα) was down-regulated whereas liver X receptor was up-regulated in LfBP1 group. Hybrid Broussonetia papyrifera (BP) has been widely planted & commonly used as ruminant forage source after fermentation in China.

   • According to Wang, Q (2024)

     Excerpt Wang, Q et al, Total Flavonoids of Broussonetia Papyrifera Alleviate Non-Alcohol Fatty Liver Disease via Regulating Nrf2/AMPK/mTOR Signaling Pathways.

   • According to Author (2022)

     Excerpt Apart from its anti-tyrosinase activity, paper mulberry and its compounds exhibited anti-inflammatory, antioxidant, antimicrobial, antiviral, anticancer, antidiabetic, anticholinesterase, antigout, antinociceptive, and hepatoprotective effects. The keywords for searching included “paper mulberry”, “Broussonetia papyrifera”, “skin-lightening”, “skin-whitening”, “depigmentation”, “pharmacological activity”, & “biological activity”.

3. 3

   Respiratory conditions: mucosal cellular hyperplasia, pleurisy, subacute pulmonary inflammation

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Wang G.W. (2012)

     Excerpt Plants belonging to the genus Broussonetia (Moraceae), which grow naturally in Asian & Pacific countries, have long been used in traditional Chinese medicine to treat various conditions, particularly tinea, dysentery, hernia & oedema.

   • According to Author (2021)

     Excerpt The general aspects, plant profile, traditional uses, distribution, major phytoconstituents, & significant pharmacotherapeutic attributes (antiviral, anti-cancer, anti-oxidant, cytotoxic potentials, anti-inflammatory, anti-diabetic, anti-microbial, anti-nociceptive, anti-gout, & anti-proliferative) mediated by various parts were all highlighted in this fascinating article. Broussonetia papyrifera, also known as paper mulberry, is a well-known conventional natural resource that has been used for decades, and the renowned advancements must be introduced to researchers for more improvement, product creation, innovative technology exploration, & the discovery of new concepts.

   • According to GUO P (2023)

     Excerpt Broussonetia papyrifera is rich in flavonoids, which have significant antioxidant, antibacterial, & anti-inflammatory activities and certain pharmacological activities. papyrifera: Several important enzyme genes involved in flavonoid production pathways have been discovered.

   • According to Author (2022)

     Excerpt Apart from its anti-tyrosinase activity, paper mulberry and its compounds exhibited anti-inflammatory, antioxidant, antimicrobial, antiviral, anticancer, antidiabetic, anticholinesterase, antigout, antinociceptive, and hepatoprotective effects. The keywords for searching included “paper mulberry”, “Broussonetia papyrifera”, “skin-lightening”, “skin-whitening”, “depigmentation”, “pharmacological activity”, & “biological activity”.

   • According to CHEN Y (2022)

     Excerpt Moreover, its active compounds & extracts have exhibited a variety of pharmacological effects such as antitumor, antioxidant, anti-inflammatory, antidiabetic, anti-obesity, antibacterial, & antiviral properties, & its use against skin wrinkles. The Broussonetia genus (Moraceae), recognized for its value in many Chinese traditional herbs, mainly includes Broussonetia papyrifera (L.) L'Hér.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.