Caesalpinia bonduc (Kannik-gri) : medicinal properties in alcoholic extraction

Caesalpinia bonduc (Kannik-gri, Zié-chat, grenn-djab, Grey Canine, Cat’s Eye, Devil’s Testicles, Canique grise, Œil-à-chat, Testicules-du-diable) — family Caesalpiniacées.

Scientific synonyms : Caesalpinia bonducella-(L)-Fleming, C. crista-(L)-Small, Guilandina bonduc-L, G. glabra-Griseb.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 23 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 61 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Widhiantara IG (2018)

     Excerpt In summary, our results suggest that ethanolic extract of CB seed possesses antidiabetic activity against experimentally-induced type 2 diabetes. This study used 24 male Wistar albino rats that were induced for type 2 diabetes with streptozotocin (STZ) & nicotinamide (NA).

   • According to Chakrabarti S (2003)

     Excerpt This prompted us to undertake a detail study with the aqueous & ethanolic extracts of the seeds of this plant in both type 1 & 2 diabetes mellitus in Long Evans rats. Caesalpinia bonducella, widely distributed throughout the coastal region of India & used ethnically by the tribal people of India for controlling blood sugar was earlier reported by us to possess hypoglycemic activity in animal model.

   • According to Meera Murugesan B (2020)

     Excerpt The aim of the current study is to evaluate the effect of ethanolic seed extract of Caesalpinia bonducella (ESECB) on altered hormonal levels in mifepristone-induced polycystic ovarian syndrome (PCOS) female rats. A significant increase (p < 0.01) in the luteinizing hormone, Prolactin, insulin, testosterone, estrone, & estradiol levels & decrease in follicle stimulating hormone & progesterone hormone levels in the PCOS rats were observed, which were normalized in the ESECB drug-treated animals.

   • According to SHUKLA S (2011)

     Excerpt In the present study, ethanolic extracts of Caesalpinia bonducella seed (ESECB) & Stevia Rebaudiana leaf (ELESR) were tested separately to compare their antidiabetic effects in normal and alloxan-induced diabetic rats. To assess the antidiabetic activity, varied concentrations of the ethanolic extracts of both plants were tested in oral glucose tolerance test to determine the blood glucose levels in normal and alloxan-induced (150 mg/kg b.w) diabetic experimental rats for 21 days.

   • According to Ahmad M (2015)

     Excerpt Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia & oxidative damage in rats. Hyperglycemic rats treated with extract in three different doses of 200, 400 & 600 mg/kg of body weight orally for 21 days shows a significant decrease in blood glucose, HbA1c, free amino groups whereas an increase in serum insulin level, liver glycogen contents with a significant improvement in glucose tolerance.

2. 2

   Type 1 diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Widhiantara IG (2018)

     Excerpt In summary, our results suggest that ethanolic extract of CB seed possesses antidiabetic activity against experimentally-induced type 2 diabetes. This study used 24 male Wistar albino rats that were induced for type 2 diabetes with streptozotocin (STZ) & nicotinamide (NA).

   • According to Chakrabarti S (2003)

     Excerpt This prompted us to undertake a detail study with the aqueous & ethanolic extracts of the seeds of this plant in both type 1 & 2 diabetes mellitus in Long Evans rats. Caesalpinia bonducella, widely distributed throughout the coastal region of India & used ethnically by the tribal people of India for controlling blood sugar was earlier reported by us to possess hypoglycemic activity in animal model.

   • According to Meera Murugesan B (2020)

     Excerpt The aim of the current study is to evaluate the effect of ethanolic seed extract of Caesalpinia bonducella (ESECB) on altered hormonal levels in mifepristone-induced polycystic ovarian syndrome (PCOS) female rats. A significant increase (p < 0.01) in the luteinizing hormone, Prolactin, insulin, testosterone, estrone, & estradiol levels & decrease in follicle stimulating hormone & progesterone hormone levels in the PCOS rats were observed, which were normalized in the ESECB drug-treated animals.

   • According to SHUKLA S (2011)

     Excerpt In the present study, ethanolic extracts of Caesalpinia bonducella seed (ESECB) & Stevia Rebaudiana leaf (ELESR) were tested separately to compare their antidiabetic effects in normal and alloxan-induced diabetic rats. To assess the antidiabetic activity, varied concentrations of the ethanolic extracts of both plants were tested in oral glucose tolerance test to determine the blood glucose levels in normal and alloxan-induced (150 mg/kg b.w) diabetic experimental rats for 21 days.

   • According to Ahmad M (2015)

     Excerpt Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia & oxidative damage in rats. Hyperglycemic rats treated with extract in three different doses of 200, 400 & 600 mg/kg of body weight orally for 21 days shows a significant decrease in blood glucose, HbA1c, free amino groups whereas an increase in serum insulin level, liver glycogen contents with a significant improvement in glucose tolerance.

3. 3

   Hepatitis, cirrhosis, alcoholic fatty liver disease

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chakrabarti S (2003)

     Excerpt Caesalpinia bonducella, widely distributed throughout the coastal region of India & used ethnically by the tribal people of India for controlling blood sugar was earlier reported by us to possess hypoglycemic activity in animal model. Special emphasis was given on the mechanistic study by gut absorption of glucose & liver glycogen.

   • According to Mandade Rajesh J (2011)

     Excerpt Hepatoprotective activity of aqueous ethanolic leaf extract of Caesalpinia bonduc against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of ETOH extract of CB on blood & liver glutathione, Na+ K+-ATPase activity, serum marker enzymes, serum Bilirubin, glycogen & Thiobarbituric acid reactive substances against paracetamol induced damage in rats have been studied to find out the possible mechanism of Hepatoprotection.

   • According to Author (2012)

     Excerpt bonduc, the determination of the antimalarial activity of each isolated phytochemical & the investigation of their in vivo toxicological effects.

   • According to Muddapur U (2014)

     Excerpt However, a slight change in liver cellular architecture was observed with tubular congestion, tubular desquamation, glomerular congestion & interstitial inflammatory cells of test animal. The histopathological studies of liver, heart, & kidney indicated either no or less alteration in the treated group.

   • According to Ahmad M (2015)

     Excerpt Hyperglycemic rats treated with extract in three different doses of 200, 400 & 600 mg/kg of body weight orally for 21 days shows a significant decrease in blood glucose, HbA1c, free amino groups whereas an increase in serum insulin level, liver glycogen contents with a significant improvement in glucose tolerance. Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia & oxidative damage in rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.