Caesalpinia bonduc (Kannik-gri) : vertus médicinales en extraction alcoolique

Caesalpinia bonduc (Kannik-gri, Zié-chat, grenn-djab, Canique grise, Œil-à-chat, Testicules-du-diable, Devil’s Testicles, Grey Canine, Cat’s Eye) — famille Caesalpiniacées.

Synonymes scientifiques : Caesalpinia bonducella-(L)-Fleming, C. crista-(L)-Small, Guilandina bonduc-L, G. glabra-Griseb.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 23 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 61 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Semence. Profil pharmacologique documenté : Glibenclamide-like, Gliclazide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Widhiantara IG (2018)

     Extrait In summary, our results suggest that ethanolic extract of CB seed possesses antidiabetic activity against experimentally-induced type 2 diabetes. This study used 24 male Wistar albino rats that were induced for type 2 diabetes with streptozotocin (STZ) & nicotinamide (NA).

   • Selon Chakrabarti S (2003)

     Extrait This prompted us to undertake a detail study with the aqueous & ethanolic extracts of the seeds of this plant in both type 1 & 2 diabetes mellitus in Long Evans rats. Caesalpinia bonducella, widely distributed throughout the coastal region of India & used ethnically by the tribal people of India for controlling blood sugar was earlier reported by us to possess hypoglycemic activity in animal model.

   • Selon Meera Murugesan B (2020)

     Extrait The aim of the current study is to evaluate the effect of ethanolic seed extract of Caesalpinia bonducella (ESECB) on altered hormonal levels in mifepristone-induced polycystic ovarian syndrome (PCOS) female rats. A significant increase (p < 0.01) in the luteinizing hormone, Prolactin, insulin, testosterone, estrone, & estradiol levels & decrease in follicle stimulating hormone & progesterone hormone levels in the PCOS rats were observed, which were normalized in the ESECB drug-treated animals.

   • Selon SHUKLA S (2011)

     Extrait In the present study, ethanolic extracts of Caesalpinia bonducella seed (ESECB) & Stevia Rebaudiana leaf (ELESR) were tested separately to compare their antidiabetic effects in normal and alloxan-induced diabetic rats. To assess the antidiabetic activity, varied concentrations of the ethanolic extracts of both plants were tested in oral glucose tolerance test to determine the blood glucose levels in normal and alloxan-induced (150 mg/kg b.w) diabetic experimental rats for 21 days.

   • Selon Ahmad M (2015)

     Extrait Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia & oxidative damage in rats. Hyperglycemic rats treated with extract in three different doses of 200, 400 & 600 mg/kg of body weight orally for 21 days shows a significant decrease in blood glucose, HbA1c, free amino groups whereas an increase in serum insulin level, liver glycogen contents with a significant improvement in glucose tolerance.

2. 2

   Diabète mellitus de type I

   Partie usitée : Semence.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Widhiantara IG (2018)

     Extrait In summary, our results suggest that ethanolic extract of CB seed possesses antidiabetic activity against experimentally-induced type 2 diabetes. This study used 24 male Wistar albino rats that were induced for type 2 diabetes with streptozotocin (STZ) & nicotinamide (NA).

   • Selon Chakrabarti S (2003)

     Extrait This prompted us to undertake a detail study with the aqueous & ethanolic extracts of the seeds of this plant in both type 1 & 2 diabetes mellitus in Long Evans rats. Caesalpinia bonducella, widely distributed throughout the coastal region of India & used ethnically by the tribal people of India for controlling blood sugar was earlier reported by us to possess hypoglycemic activity in animal model.

   • Selon Meera Murugesan B (2020)

     Extrait The aim of the current study is to evaluate the effect of ethanolic seed extract of Caesalpinia bonducella (ESECB) on altered hormonal levels in mifepristone-induced polycystic ovarian syndrome (PCOS) female rats. A significant increase (p < 0.01) in the luteinizing hormone, Prolactin, insulin, testosterone, estrone, & estradiol levels & decrease in follicle stimulating hormone & progesterone hormone levels in the PCOS rats were observed, which were normalized in the ESECB drug-treated animals.

   • Selon SHUKLA S (2011)

     Extrait In the present study, ethanolic extracts of Caesalpinia bonducella seed (ESECB) & Stevia Rebaudiana leaf (ELESR) were tested separately to compare their antidiabetic effects in normal and alloxan-induced diabetic rats. To assess the antidiabetic activity, varied concentrations of the ethanolic extracts of both plants were tested in oral glucose tolerance test to determine the blood glucose levels in normal and alloxan-induced (150 mg/kg b.w) diabetic experimental rats for 21 days.

   • Selon Ahmad M (2015)

     Extrait Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia & oxidative damage in rats. Hyperglycemic rats treated with extract in three different doses of 200, 400 & 600 mg/kg of body weight orally for 21 days shows a significant decrease in blood glucose, HbA1c, free amino groups whereas an increase in serum insulin level, liver glycogen contents with a significant improvement in glucose tolerance.

3. 3

   Hépatite, cirrhose, stéatose alcoolique

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Chakrabarti S (2003)

     Extrait Caesalpinia bonducella, widely distributed throughout the coastal region of India & used ethnically by the tribal people of India for controlling blood sugar was earlier reported by us to possess hypoglycemic activity in animal model. Special emphasis was given on the mechanistic study by gut absorption of glucose & liver glycogen.

   • Selon Mandade Rajesh J (2011)

     Extrait Hepatoprotective activity of aqueous ethanolic leaf extract of Caesalpinia bonduc against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of ETOH extract of CB on blood & liver glutathione, Na+ K+-ATPase activity, serum marker enzymes, serum Bilirubin, glycogen & Thiobarbituric acid reactive substances against paracetamol induced damage in rats have been studied to find out the possible mechanism of Hepatoprotection.

   • Selon Auteur (2012)

     Extrait bonduc, the determination of the antimalarial activity of each isolated phytochemical & the investigation of their in vivo toxicological effects.

   • Selon Muddapur U (2014)

     Extrait However, a slight change in liver cellular architecture was observed with tubular congestion, tubular desquamation, glomerular congestion & interstitial inflammatory cells of test animal. The histopathological studies of liver, heart, & kidney indicated either no or less alteration in the treated group.

   • Selon Ahmad M (2015)

     Extrait Hyperglycemic rats treated with extract in three different doses of 200, 400 & 600 mg/kg of body weight orally for 21 days shows a significant decrease in blood glucose, HbA1c, free amino groups whereas an increase in serum insulin level, liver glycogen contents with a significant improvement in glucose tolerance. Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia & oxidative damage in rats.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.