Cajanus cajan (Pwa dangôl) : medicinal properties in alcoholic extraction

Cajanus cajan (Pwa dangôl, Angolan peas, Pois d’Angole) — family Fabacées.

Scientific synonyms : ---------.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 47 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Manzo JAM (2017)

     Excerpt Aims: Aims and objectives are to evaluate the effects of ethanolic extracts of Cajanus cajan (CCEE) leaves on its Antihyperglycemic effects on BGL of normoglycemic mice. Diabetes mellitus is a metabolic disease that is usually associated with abnormalities in the metabolism of different substrates leading to high blood glucose levels (BGL).

   • According to Ezike AC (2010)

     Excerpt Ezike AC et al, Experimental evidence for the antidiabetic activity of Cajanus cajan leaves in rats.

   • According to Brito SA (2012)

     Excerpt Brito SA et al, Evaluation of the antifungal activity and modulation between Cajanus cajan (L.) Millsp leaves and roots ethanolic extracts and conventional antifungals, Pharmacogn Mag 2012, 8 (30): 103-6.-BACKGROUND: The use and investigation of natural products with antimicrobial activity from vegetal source have been reported by several researchers. MATERIALS & METHODS: This study shows the characterization of secondary metabolites present in ethanolic extracts from leaves and roots of Cajanus cajan by phytochemical prospection.

2. 2

   Hepatitis, fatty liver, cirrhosis

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Akinoye AO (2011)

     Excerpt The aim of the study to investigate the hepatoprotective effect of the C cajan ethanolic extract on hepatic antioxidant status in D-galactosamine-induced hepatitis rats by measuring the extent of oxidative damage as well as the state of the antioxidant defense system. Material & Methods: Ethanolic extract of C cajan was administered orally (100mg/kg body weight) and the effect of the extract on the activities of Alanine Aminotransferase, Aspartate Aminotransferase, Catalase, Superoxide Dismutase, Glutathione Peroxidase, Glutathione-S-transferase as well as the levels of Malondialdehyde and reduced glutathione were estimated in D-galactosamine induced hepatitis rats.

   • According to Sinha MP (n.d.)

     Excerpt Since the protein possess hepatoprotective activity, it may first ameliorate GalN-induced liver damage & consequently the renal disorders are reduced. As GalN induced severe hepatotoxicity followed by renal failure, the protective role of the protein against GalN induced renal damages is likely to be an indirect effect.

   • According to MANNA P (2007)

     Excerpt The present study was conducted to determine the protective role of a 43-kD protein isolated from the leaves of the herb Cajanus indicus L against D (+)-galactosamine (GalN) induced liver damage in mice. Results suggest that GalN caused hepatic damages via oxidative insult & that the protein provided protection through its antioxidant mechanism,.

   • According to MANNA P (2007)

     Excerpt The herb, Cajanus indicus L, is well known for its hepatoprotective action. This exposure significantly altered the activities of the antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR) & the cellular metabolites such as reduced glutathione (GSH), oxidized glutathione (GSSG), total thiols, lipid peroxidation end products in liver & kidney compared to the normal mice.

   • According to Prema L (1973)

     Excerpt Prema L et al, Effect of protein fractions from Cajanus cajan (red gram) & Dolichos biflorus (horse gram) on the serum, liver & aortic lipid levels in rats fed a high-fat-high-cholesterol diet.

3. 3

   Bacterial infection: Bacillus subtilis, Staphylococcus aureus, Streptococcus pneumoniae, Salmonella typhi, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pratima H (2011)

     Excerpt were extracted in various organic solvents such as pet ether, chloroform, methanol, ethanol & aqueous & were tested against Bacillus subtilis, staphylococcus aureus, Streptococcus pneumonia, Salmonella typhi, Klebsiella pneumoniae, Escherichia coli, & Pseudomonas aeruginosa using agar well diffusion method. The ethanolic extract showed the highest activity on all the Gram-positive bacteria & Gram-negative bacteria Klebsiella pneumonia at 100mg/mL, whereas Pseudomonas aeruginosa was resistant to all the extracts except ethanol.

   • According to Hasan SF (2013)

     Excerpt Antibacterial activities of four different extracts of Cajanus cajan L. For characterization of Bacillus spp the PCR amplified 16S rDNA were sequenced and individual sequence was compared with NCBI database information using BLAST search.

   • According to Brito SA (2012)

     Excerpt Brito SA et al, Evaluation of the antifungal activity and modulation between Cajanus cajan (L.) Millsp leaves and roots ethanolic extracts and conventional antifungals, Pharmacogn Mag 2012, 8 (30): 103-6.-BACKGROUND: The use and investigation of natural products with antimicrobial activity from vegetal source have been reported by several researchers. MATERIALS & METHODS: This study shows the characterization of secondary metabolites present in ethanolic extracts from leaves and roots of Cajanus cajan by phytochemical prospection.

   • According to Zu YG (2010)

     Excerpt Zu YG et al, Chemical composition of SFE-CO2 extracts from Cajanus cajan (L.) Huth & their antimicrobial activity in vitro & in vivo.

   • Excerpt According to Zu Y (2010) — excerpt:

   • Excerpt According to our findings, a therapeutic application of Cajanus ethanolic extracts containing crème or ointment as antiviral agent in recurrent HSV infection appears to be promising. Aqueous and ethanolic extracts of Cajanus cajan (Fabaceae) were examined in vitro for their antiviral activity against herpès simplex virus type 1 (HSV-1) and type 2 (HSV-2).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.