Capparis spinosa (Gwo Mouzanmbé: Gwo kaya) : medicinal properties in alcoholic extraction

Capparis spinosa (Gwo Mouzanmbé: Gwo kaya, Babinn chat, Zèb-djab, Big Mouzambé, Big Acaya, cat’s lip, fatty grass, Gwo Mouzanmbé :Gwo kaya, Gros Mouzambé, gros Acaya, babine -à-chat, herbe grasse) — family Capparacées.

Scientific synonyms : Capparis ovata auct non Desf, Cleome pingens-Willd.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 21 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 170 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for colorectal, liver and breast cancer

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to SUN Y (2023)

     Excerpt spinosa possesses various biological activities, including antioxidant, antidiabetic, anticancer, hepatoprotective, neuroprotective, anti-inflammatory, anti-arthritic, antibacterial, & insecticidal effects. as a potential source of nutrition & its health benefits in foods: A comprehensive review of its phytochemistry, bioactivities, safety, & application, Food Chem, 409 :135258, 2023-Absract: Capparis spinosa L.

   • According to Aichour R (2018)

     Excerpt the aim of this study was to evaluate anti-inflammatory & hepatoprotective effects of methanolic extracts from fruits & leaves of Capparis spinosa. For hepatoprotective activity, liver injury was induced in male Wistar mice by administration of CCl4 (1 ml / kg of CCl4 30% in olive oil,), while CS leaf extract (CSLE) & fruit extract (CSFE) were administered orally to the experimental animals.

   • According to Kalantari H (2018)

     Excerpt Among these fractions, hydroalcoholic extract was used to assess the hepatoprotective effect in tert-butyl hydroperoxide (t-BHP) induced hepatotoxicity model by determining serum biochemical markers, sleeping time & antioxidant assay such as reduced glutathione (GSH) as well as histopathological examination of liver tissues. The present study investigates the antioxidant and hepatoprotective effects of Capparis spinosa L.

   • According to Mollica A (2017)

     Excerpt In this study, the nutraceutical potential of Capparis spinosa L. At the end of the experiment, animals were sacrificed, blood taken for assessment of lipid profile and liver/kidney biochemistry while section of the pancreas, kidneys were processed for general histology.

   • According to Abkari (2015)

     Excerpt histopathological examinations showed that liver steatosis, inflammation, & hepatic fibrosis were markedly attenuated in response to CS & fenofibrate interventions. Capparis spinosa (CS) belongs to the family of Capparidaceae & is a traditional plant used to treat various diseases, particularly dyslipidemia.

2. 2

   Liver disorders: abnormal serum levels of: ALT, ALP, AST, MDA, GSH, SOD, catalase

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kalantari H (2018)

     Excerpt Among these fractions, hydroalcoholic extract was used to assess the hepatoprotective effect in tert-butyl hydroperoxide (t-BHP) induced hepatotoxicity model by determining serum biochemical markers, sleeping time & antioxidant assay such as reduced glutathione (GSH) as well as histopathological examination of liver tissues. The present study investigates the antioxidant and hepatoprotective effects of Capparis spinosa L.

   • According to SUN Y (2023)

     Excerpt spinosa possesses various biological activities, including antioxidant, antidiabetic, anticancer, hepatoprotective, neuroprotective, anti-inflammatory, anti-arthritic, antibacterial, & insecticidal effects. as a potential source of nutrition & its health benefits in foods: A comprehensive review of its phytochemistry, bioactivities, safety, & application, Food Chem, 409 :135258, 2023-Absract: Capparis spinosa L.

   • According to Yusufoglu H (2014)

     Excerpt Both extracts displayed hepatoprotective effect in a dose dependent manner as evident by reduced levels of serum ALT, AST, ALP, γ-GT & hepatic MDA concentration, as well as higher CAT, GPx, SOD activities & GSH concentration compared to TAA-intoxicated controls. In the liver, significantly elevated level of malondialdehyde (MDA), lowered levels of reduced glutathione (GSH), catalase (CAT), glutathione peroxidase (GPx) & superoxide dismutase (SOD) were observed following TAA injection.

   • According to Mollica A (2017)

     Excerpt Results showed that the regular administration of CS leaf or buds normalized all the biochemical parameters & reversed the liver/kidney injury with variable degrees of organ protection. In this study, the nutraceutical potential of Capparis spinosa L.

   • According to Ali Al-Nuani RM (2020)

     Excerpt The aqueous Capparis spinosa extract (CSE)(500 mg/kg) was used to reduce the hepatotoxicity induced by paracetamol (PARA)(300mg/kg). The PARA (300mg/kg) increased the CYP450 2E1 & reduced the GSH serum levels significantly when compared with the control group (P<0.05).

3. 3

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Huseini H.F (2013)

     Excerpt Design: The present study was undertaken to explore the possible anti-hyperglycemic effects of the CS fruit extract in type 2 diabetic patients. Conclusions: CS fruit extract may be a safe anti-hyperglycemic & anti-hypertriglyceridaemic agent for type 2 diabetic patients.

   • According to Perna S (2023)

     Excerpt RCTs with CS fruit supplementation or consumption in different cohorts of subjects with non-alcoholic fatty liver disease (NAFLD), Type-2-Diabetes (T2D), metabolic syndrome, & hyperlipidemia were included in this systematic review with a mean intervention duration from 2 to 12 weeks. In conclusion, this systematic review & meta-analysis showed the paucity of data available on the topic while showing the potential role of CS fruit as a promising food for improving the liver-lipid profile axis in patients with metabolic syndrome & diabetes.

   • According to Jalali MT (2016)

     Excerpt The present study aimed to investigate the effects of administration of Capparis spinosa (CS) fruit aqueous extract on liver metabolism in streptozotocin (STZ)-induced diabetic rats. The aqueous extract of CS was orally administered at a dose of 20mg/kg for 28 consecutive days & then its effects on blood glucose, lipid & insulin levels in normal & STZ diabetic rats were comparatively investigated.

   • According to Kazemian M (2015)

     Excerpt Conclusion: These results showed that CS root extract could improve diabetic related metabolic derangement such as hyperglycemia, dyslipidemia, & elevated liver markers in an insulin-independent manner,. Rats were rendered diabetic (streptozotocin 60 mg/kg, i.p.) & treated with 0.2, 0.4 g/ kg of plant extract or Glibenclamide for four weeks.

   • According to Eddouks M (2005)

     Excerpt The purpose of this study was to examine the effect of single & repeated oral administrations of the aqueous extract of Capparis spinosa L. (CS) at a dose of 20mg/kg on lipid metabolism in normal & streptozotocin-induced diabetic rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.