Carissa carandas (Trumpet of Christ) : medicinal properties in alcoholic extraction

Carissa carandas (Trumpet of Christ, Karanda, Trompette du Christ) — family Apocynacées.

Scientific synonyms : Arduina carandas (L.) Baill, Capparis carandas (L.) Burm.f., Jasminonerium salicinum (Lam.) Kuntze.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 19 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 85 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hegde K (2009)

     Excerpt carandas (ERCC; 100, 200 & 400 mg/kg, po) showed significant hepatoprotective activity against CCl4 & paracetamol induced hepatotoxicity by decreasing the activities of serum marker enzymes, bilirubin & lipid peroxidation, and significant increase in the levels of uric acid, glutathione, super oxide dismutase, catalase & protein in a dose dependent manner, which was confirmed by the decrease in the total weight of the liver & histopathological examination. Data also showed that ERCC possessed strong antioxidant activity, which may probably lead to the promising hepatoprotective activities of CC root extract.

   • According to Ondee S (2019)

     Excerpt Carissa carandas Linn. Antiproliferative activity was also analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay against human cancer cell lines; KB (human epidermoid carcinoma), MCF-7 (human breast adenocarcinoma), SiHa (human cervical carcinoma) & HepG2 (human hepatocellular carcinoma) cell lines, as well as non-tumorigenic cells; Vero (African green monkey kidney) cell line.

   • According to Al-Desoky AH (2018)

     Excerpt The hepatoprotective effect of CCDE was evaluated by detecting its effects on serum liver function markers & liver cell oxidative stress markers. The leaves of Carissa carandas may be rich in compounds that can be used as safe anti-inflammatory & antioxidant remedies.

   • According to Bhati P (2016)

     Excerpt Bhati P et al, HEPATOPROTECTIVE ACTIVITY OF LEAVES EXTRACTS OF CARISSA CARANDAS LINN, Inter J of Adv in Agric Sci & Technol.

   • According to Sumbul S (2014)

     Excerpt The Purpose of this research study was to examine the toxicological effects of aqueous: ethanol (1:1) extract of Carissa carandas leaves extracts in rats. Autopsy after acute toxicity revealed that no gross changes were observed in organs like liver, spleen, heart & kidney among the animals of group N (control) & S (treated).

2. 2

   Cancer: adjuvant treatment for invasive ductal breast carcinoma

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kiruthika P (2021)

     Excerpt IDC (Invasive Ductal carcinoma) breast cancer protein- Aromatase was selected as target which is an estrogen synthesizing enzyme. This work aimed at determining the active compound from Carissa carandas fruit, which proved to control the growth of cancer cells & this fruit is abundantly found in Tamilnadu, India.

   • According to Ondee S (2019)

     Excerpt Antiproliferative activity was also analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay against human cancer cell lines; KB (human epidermoid carcinoma), MCF-7 (human breast adenocarcinoma), SiHa (human cervical carcinoma) & HepG2 (human hepatocellular carcinoma) cell lines, as well as non-tumorigenic cells; Vero (African green monkey kidney) cell line. Carissa carandas Linn.

   • According to Sudjaoren Y (2017)

     Excerpt Materials & Methods: Anticancer activities of CC fruits extracted with dichloromethane (KD) & methanol (KM) were performed by resazurin microplate assay & tested with five cell lines, including KB-oral cavity cancer, MCF7-breast cancer, NCI-H187-small lung cancer, Hep-G2-hepatocarcinoma, & Caco2-colon adenocarcinoma cell lines. Results: Both extracts were not possessed anticancer activity to any cancer cell lines at maximum concentration = 100 μg/mL.

   • According to David M (2015)

     Excerpt Carissa carandas belongs to the Apocynaceae family and widely spread throughout India. Furthermore, in-vitro studies showed that AEE possesses lowest MIC value 0.3125 mg/ml & induces cytotoxicity at 800μg/mL on HeLa cancer cells.

   • According to Khatun M (2017)

     Excerpt The methanol extract of Carissa carandas leaves (MELC) was applied on DPPH & ABTS experiments to determine its antioxidant activity. In vitro the cytotoxic effect of MELC was evaluated against colonic adenocarcinoma cell lines (SW-480 and SW-48) whereas in vivo its antineoplastic property was tested against Ehrlich ascites carcinoma (EAC).

3. 3

   Bacterial infection: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Jampa O (n.d.)

     Excerpt Their antibacterial activity was tested against Staphylococcus aureus,Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa & Bacillus subtilis.Their anti-inflammatory activity was determined using nitric oxide (NO) inhibitory assay in LPSstimulated RAW 264.7 macrophage cells. Karandas or Namdaeng (Carissa carandas L.) is a fruit traditionally used to treat skin & abdominal diseases.

   • According to Pathak G (2021)

     Excerpt Both the extracts inhibited the growth of cancer cell lines & showed moderate activity against Staphylococcus aureus, Streptococcus mutans, & Mycobacterium smegmatis in a dose-dependent manner. Carissa carandas (Apocynaceae), a tropical plant popularly known as karonda in India, is being commonly used as a condiment in pickles & spices.

   • According to Singh D (2017)

     Excerpt Finally, biosynthesised AgNPs were scrutinised for their antibacterial activity against methicillin-resistant Staphylococcus aureus, Shigella sonnei, Shigella boydii & Salmonella typhimurium. Facile green synthesis of silver nanoparticles (AgNPs) using an aqueous extract of Carissa carandas leaves was studied.

   • According to Singh B (2015)

     Excerpt In this study, aqueous & ethanolic extract leaves/fruits of three commonly available medicinal plants (Mentha arvensis, Carissa carandas & Calendula officinalis) individually & in combinations were tested for their antimicrobial activity against three different pathogenic bacteria (Bacillus cereus (MCCB-0143), Staphylococcus aureus (MCCB-0139) & Escherichia coli (MCCB-0018)) using agar disc diffusion, agar well diffusion. cereus & F112 (fruits Calendula: C carandas: M arvensis, 1:2:1) showed significant (P < 0.05) antimicrobial activity against S.

   • According to Agarwal T (2012)

     Excerpt Agarwal T et al, In vitro study of antibacterial activity of Carissa carandas leaf extracts, Asian J of Plant Sci & Res, 2012, 2 (1):36-40,.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.