Carissa carandas (Trompette du Christ) : vertus médicinales en extraction alcoolique

Carissa carandas (Trompette du Christ, Karanda, Trumpet of Christ) — famille Apocynacées.

Synonymes scientifiques : Arduina carandas (L.) Baill, Capparis carandas (L.) Burm.f., Jasminonerium salicinum (Lam.) Kuntze.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 19 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 85 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Hépatite, cirrhose, stéatose hépatique

   Partie usitée : Racine.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Hegde K (2009)

     Extrait carandas (ERCC; 100, 200 & 400 mg/kg, po) showed significant hepatoprotective activity against CCl4 & paracetamol induced hepatotoxicity by decreasing the activities of serum marker enzymes, bilirubin & lipid peroxidation, and significant increase in the levels of uric acid, glutathione, super oxide dismutase, catalase & protein in a dose dependent manner, which was confirmed by the decrease in the total weight of the liver & histopathological examination. Data also showed that ERCC possessed strong antioxidant activity, which may probably lead to the promising hepatoprotective activities of CC root extract.

   • Selon Ondee S (2019)

     Extrait Carissa carandas Linn. Antiproliferative activity was also analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay against human cancer cell lines; KB (human epidermoid carcinoma), MCF-7 (human breast adenocarcinoma), SiHa (human cervical carcinoma) & HepG2 (human hepatocellular carcinoma) cell lines, as well as non-tumorigenic cells; Vero (African green monkey kidney) cell line.

   • Selon Al-Desoky AH (2018)

     Extrait The hepatoprotective effect of CCDE was evaluated by detecting its effects on serum liver function markers & liver cell oxidative stress markers. The leaves of Carissa carandas may be rich in compounds that can be used as safe anti-inflammatory & antioxidant remedies.

   • Selon Bhati P (2016)

     Extrait Bhati P et al, HEPATOPROTECTIVE ACTIVITY OF LEAVES EXTRACTS OF CARISSA CARANDAS LINN, Inter J of Adv in Agric Sci & Technol.

   • Selon Sumbul S (2014)

     Extrait The Purpose of this research study was to examine the toxicological effects of aqueous: ethanol (1:1) extract of Carissa carandas leaves extracts in rats. Autopsy after acute toxicity revealed that no gross changes were observed in organs like liver, spleen, heart & kidney among the animals of group N (control) & S (treated).

2. 2

   Cancer: traitement adjuvant du carcinome : mammaire ductal invasif

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Kiruthika P (2021)

     Extrait IDC (Invasive Ductal carcinoma) breast cancer protein- Aromatase was selected as target which is an estrogen synthesizing enzyme. This work aimed at determining the active compound from Carissa carandas fruit, which proved to control the growth of cancer cells & this fruit is abundantly found in Tamilnadu, India.

   • Selon Ondee S (2019)

     Extrait Antiproliferative activity was also analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay against human cancer cell lines; KB (human epidermoid carcinoma), MCF-7 (human breast adenocarcinoma), SiHa (human cervical carcinoma) & HepG2 (human hepatocellular carcinoma) cell lines, as well as non-tumorigenic cells; Vero (African green monkey kidney) cell line. Carissa carandas Linn.

   • Selon Sudjaoren Y (2017)

     Extrait Materials & Methods: Anticancer activities of CC fruits extracted with dichloromethane (KD) & methanol (KM) were performed by resazurin microplate assay & tested with five cell lines, including KB-oral cavity cancer, MCF7-breast cancer, NCI-H187-small lung cancer, Hep-G2-hepatocarcinoma, & Caco2-colon adenocarcinoma cell lines. Results: Both extracts were not possessed anticancer activity to any cancer cell lines at maximum concentration = 100 μg/mL.

   • Selon David M (2015)

     Extrait Carissa carandas belongs to the Apocynaceae family and widely spread throughout India. Furthermore, in-vitro studies showed that AEE possesses lowest MIC value 0.3125 mg/ml & induces cytotoxicity at 800μg/mL on HeLa cancer cells.

   • Selon Khatun M (2017)

     Extrait The methanol extract of Carissa carandas leaves (MELC) was applied on DPPH & ABTS experiments to determine its antioxidant activity. In vitro the cytotoxic effect of MELC was evaluated against colonic adenocarcinoma cell lines (SW-480 and SW-48) whereas in vivo its antineoplastic property was tested against Ehrlich ascites carcinoma (EAC).

3. 3

   Infection bactérienne: Bacillus-subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Jampa O (s.d.)

     Extrait Their antibacterial activity was tested against Staphylococcus aureus,Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa & Bacillus subtilis.Their anti-inflammatory activity was determined using nitric oxide (NO) inhibitory assay in LPSstimulated RAW 264.7 macrophage cells. Karandas or Namdaeng (Carissa carandas L.) is a fruit traditionally used to treat skin & abdominal diseases.

   • Selon Pathak G (2021)

     Extrait Both the extracts inhibited the growth of cancer cell lines & showed moderate activity against Staphylococcus aureus, Streptococcus mutans, & Mycobacterium smegmatis in a dose-dependent manner. Carissa carandas (Apocynaceae), a tropical plant popularly known as karonda in India, is being commonly used as a condiment in pickles & spices.

   • Selon Singh D (2017)

     Extrait Finally, biosynthesised AgNPs were scrutinised for their antibacterial activity against methicillin-resistant Staphylococcus aureus, Shigella sonnei, Shigella boydii & Salmonella typhimurium. Facile green synthesis of silver nanoparticles (AgNPs) using an aqueous extract of Carissa carandas leaves was studied.

   • Selon Singh B (2015)

     Extrait In this study, aqueous & ethanolic extract leaves/fruits of three commonly available medicinal plants (Mentha arvensis, Carissa carandas & Calendula officinalis) individually & in combinations were tested for their antimicrobial activity against three different pathogenic bacteria (Bacillus cereus (MCCB-0143), Staphylococcus aureus (MCCB-0139) & Escherichia coli (MCCB-0018)) using agar disc diffusion, agar well diffusion. cereus & F112 (fruits Calendula: C carandas: M arvensis, 1:2:1) showed significant (P < 0.05) antimicrobial activity against S.

   • Selon Agarwal T (2012)

     Extrait Agarwal T et al, In vitro study of antibacterial activity of Carissa carandas leaf extracts, Asian J of Plant Sci & Res, 2012, 2 (1):36-40,.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.