Carum carvi (Caraway) : medicinal properties in alcoholic extraction

Carum carvi (Caraway, Mountain Cumin, Carvi, Cumin des Montagnes) — family Apiacées.

Scientific synonyms : Carum carvi-(L)-Cranz, falcaria carifolia-CAM, Foenicumul carvi-(L)-Link, Pimpinella carvi-(L)-Jess, Sium carvi-(L)-Benth.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 60 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Seed. Mentioned synergistic association: Hibiscus sabdariffa-calice.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2020)

     Excerpt The present study aimed to determine the hypoglycemic effect of Afghan Hibiscus sabdariffa L & Carum Carvi L. Streptozotocin-induced diabetic rats were administered intraperitoneally with hydro-alcoholic extracts of Hs (75, 150 & 300 mg/kg), CC (150, 300 & 500 mg/kg) & their combinations for 21 days.

   • According to Hajlaoui H (2021)

     Excerpt Therefore, this study aims to perform a chemical analysis of both essential oils (EOs) from the seeds of Carum carvi (C. A high & equipotent antidiabetic activity was observed for the mixture (IC50 = 0.75 ± 0.15 mg/mL) when compared to the standard drug, acarbose, which is about nine times higher than each EO alone.

   • According to Lemhadri A (2006)

     Excerpt The purpose of this study was to examine the effect of single & repeated oral administration of the aqueous extract of Carum carvi fruits at a dose of (20mg/kg) on lipid metabolism in normal & streptozotocin-induced diabetic rats (STZ). In STZ diabetic rats, cholesterol levels were decreased significantly 6h after Carum carvi treatment (p<0.05).

   • According to Abou El-Soud NH (2014)

     Excerpt Thirty male albino rats were divided into three groups: normal control (group A), diabetic positive control (group B), & experimental (group C) receiving C carvi oil as a renoprotective agent at 10 mg/kg of body weights orally. This could be contributed to Carum carvi constituents, especially carvone γ –Terpinene & Limonene which have strong antioxidant activity.

   • According to Haidari F (2011)

     Excerpt To evaluate the effect of oral administration of caraway (Carum carvi) on the blood glucose level, lipid profile, & the weight of diabetic rats. Diabetes was induced by intraperitoneal injection of 60 mg/kg body weight streptozotocin.

2. 2

   Cancer: adjuvant treatment for leukaemia

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Naghibi SM (2015)

     Excerpt Observing this dramatic change in TSH level by Carum ingestion, C carvi capsules was produced and one of the researchers tried the medication on herself with a dose of 40 mg/kg/day. We report a patient with papillary thyroid carcinoma who were under treatment with levothyroxine and experienced an elevated TSH level by ingestion of C carvi.

   • According to Kamaleeswari M (2006)

     Excerpt Thus, our study showed that caraway supple-mentation at a dose of 60mgkg had a modulatory role on tissue LPO, antioxidant profile and prevented DMH-induced histopathological lesions in colon cancer rats. To induce colon cancer, rats were given a weekly subcutaneous injection of1, 2-dimethylhydrazine (DMH) at a dose of 20mgkg (based on body weight) for the first 15 weeks.

   • According to Zheng Q (1992)

     Excerpt Bioassay-directed fractionation of dill weed oil & caraway oil, respectively, from the plants Anethum graveolens L. The alpha, beta-unsaturated ketone system in carvone appeared to be critical for the high enzyme-inducing activity.

   • According to Aly A (2022)

     Excerpt Furthermore, the caraway essential oils indicated anticancer activity against the two cell lines studied; colorectal adenocarcinoma (Caco-2) & liver cancer cell line (HepG-2) as reduced the cell viability & density. Additionally, the caraway EOs have anticancer activity against the two cell lines studied; colorectal adenocarcinoma (Caco-2) & liver cancer cell line (HepG-2) as reduced the cell viability & density.

   • According to Bogucka-Kocka A (2008)

     Excerpt The apoptotic activities of seven ethanol extracts from fruits of seven species of Apiaceae, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare, Levisticum officinale against ML-1--human acute myeloblastic leukaemia, J-45.01--human acute T cell leukaemia, EOL--human eosinophilic leukaemia, HL-60--human Caucasian promyelocytic leukaemia, 1301--human T cell leukaemia lymphoblast, C-8166--human T cell leukaemia, U-266B1--human myeloma, WICL--human Caucasian normal B cell, and H-9--human T cell, were investigated.

3. 3

   Colitis, inflammatory bowel disease, Crohn’s disease

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Keshavarz A (2013)

     Excerpt Anti-inflammatory, spasmolytic, antimicrobial, antioxidant, carminative and immunomodulatory properties of caraway suggest that it might exert beneficial effects on inflammatory bowel disease (IBD). Therefore, this study was carried out to investigate the effects of caraway hydroalcoholic extract (CHE) and its essential oil (CEO) in an immunological model of colitis in rats induced by trinitrobenzene sulfonic acid (TNBS).

   • According to Naghibi SM (2015)

     Excerpt Observing this dramatic change in TSH level by Carum ingestion, C carvi capsules was produced and one of the researchers tried the medication on herself with a dose of 40 mg/kg/day. Carum carvi is a widely available herb that has been used as a food additive and as a medication in traditional medicine for many years.

   • According to Roome T (2021)

     Excerpt Digas colic drops (DCD-684) a polyherbal formulation containing Carum carvi, Foeniculum vulgare, Mentha arvensis, Mentha piperita & Zingiber officinale is widely used in Pakistan against gastrointestinal ailments including infantile colic. However, at 18 & 36 ml/kg.bw, liver demonstrated mild inflammation correlating with raised aspartate transaminase (AST), alkaline phosphatase (ALP) & alpha fetoprotein (AFP) levels.

   • According to Roome T (2021)

     Excerpt Digas colic drops (DCD-684) is a polyherbal formulation containing decoctions of five medicinal plants namely Carum carvi L., Foeniculum vulgare Mill, Mentha arvensis L., Mentha piperita L. Thereby, providing the pharmacological basis of its therapeutic use in the gastrointestinal motility disorders & related inflammatory ailments.

   • According to Yosefi SS (2014)

     Excerpt Yosefi SS et al, Effectiveness of Carum carvi on early return of bowel motility after caesarean section.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.