Casearia sylvestris (Dog poo) : medicinal properties in alcoholic extraction

Casearia sylvestris (Dog poo, Ti-kafé mawon, Dog flea, Little brown coffee, Pis-chien, Puce-à-chien, Petit café marron) — family Flacourtiacées.

Scientific synonyms : Casearia samyda-C.F., Guidonia sylvestris-(Sw)-Maza, Samyda parviflora-L, S sylvestris-(Sw)-Poir..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 58 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of breast cancer and ascites

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Da Silva S (2009)

     Excerpt Since the direct in vitro activity against Ehrlich tumor & Lewis’s lung cancer cells was low, we investigated the effects of MGDE or IGDE treatment on the activity of total natural killer cells from Ehrlich ascites tumor-bearing mice, as a possible explanation for the mechanisms of these compounds in vivo. Both compounds presented similar & low in vitro cytotoxicity against Ehrlich ascites tumor cells & & not present any significant toxicity against Lewis’s lung cancer cells.

   • According to Bettega FK (2014)

     Excerpt Antiproliferative effects in vivo were measured in tumor tissue from Ehrlich ascites-bearing mice through the 3H-thymidine uptake assay & the trypan blue exclusion method Results: In vitro, EC50 values found at 24 h on MCF-7 cells were 141 µg/mL for CAE & 66 µg/mL for f-CHCl3. This article reports the results of an investigation about the antiproliferative effects of C sylvestris on tumor cells in vitro & in vivo.

   • According to Dos Santos AG (2010)

     Excerpt An EtOH extract of the leaves of Casearia sylvestris afforded new clerodane diterpene, Casearin X, together with the known compounds casearins B, D, L, & O, & caseargrewiin F. The diterpenes isolated were cytotoxic to human cancer cell lines, with caseargrewiin F being the most active & the new clerodane, Casearin X, the second active compound with IC (50) values comparable to the positive control Doxorubicin.

   • According to Itokawa H (1988)

     Excerpt Antitumor principles from Casearia sylvestris Sw (Flacourtiaceae), structure élucidation of new clerodane diterpènes by 2-D NMR Spectroscopy Chem Pharm Bull (Tokyo) 1988; 36(4): 1585–8.

   • According to Itokawa H (1990)

     Excerpt New antitumor principles, casearins A–F, for Casearia sylvestris Sw.

2. 2

   Arthritis, osteoarthritis, rheumatism, oedema

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Esteves I (2005)

     Excerpt To investigate the antiulcer & antiinflammatory activities of the essential oil from Casearia sylvestris leaves (EOCS) the following tests were used: rat paw edema, granulomatous tissue test, vascular permeability, writhing test, gastric ulcer stress-induced & evaluation of gastric secretion (pylorus ligation test). With the overall results obtained in this study the authors suggest an anti-inflammatory activity for the EOCS of Casearia sylvestris beyond its anti-ulcer activity.

   • According to Portella de Campos DL (2015)

     Excerpt As in Brazil Casearia sylvestris Sw., popularly known as Guaçatonga is widely used for its analgesic, antiseptic and anti-inflammatory activities, this study sought to evaluate the effects of its hydroalcoholic extract in healing process of burns injuries. The anti-inflammatory & bactericidal effects of C.S suggests a potential therapeutic benefit in the treatment of inflammatory conditions in second-degree scald burn injuries, as well as, counteracting against the in vitro paralysis induced by B.

   • According to De Campos EP (2015)

     Excerpt As in Brazil Casearia sylvestris Sw., popularly known as Guaçatonga is widely used for its analgesic, antiseptic & anti-inflammatory activities, this study sought to evaluate the effects of its hydroalcoholic extract in healing process of burns injuries. Conclusion: The anti-inflammatory & bactericidal effects of CS suggest a potential therapeutic benefit in the treatment of inflammatory conditions in second-degree scald burn injuries, as well as, counteracting against the in vitro paralysis induced by B.

   • According to Heymans AC (2020)

     Excerpt To evaluate the topical anti-inflammatory activity for the crude hydroalcoholic extract of Casearia sylvestris (HCE-CS) in the models of single or multiple administration of croton oil to induce ear edema in mice. Casearia sylvestris is a plant used topically in different communities in Brazil, to treat wounds or promote cutaneous healing.

   • According to Pierri (2017)

     Excerpt Carrageenan-induced paw edema and carrageenan-induced pleurisy assays (rats) were used to evaluate anti-inflammatory activity of ethanolic extract, its fractions and clerodane diterpenes from C. The present study aimed to investigate the anti-inflammatory activity of ethanolic extract from C sylvestris leaves and to identify the compounds responsible for this activity.

3. 3

   Abdominal pain: gastric lesions caused by Helicobacter pylori

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pierri (2017)

     Excerpt The present study aimed to investigate the anti-inflammatory activity of ethanolic extract from C sylvestris leaves and to identify the compounds responsible for this activity. sylvestris leaves was fractionated by solid phase extraction & the chemical composition of extract and fractions were assessed by chromatographic techniques.

   • According to Esteves I (2005)

     Excerpt To investigate the antiulcer & antiinflammatory activities of the essential oil from Casearia sylvestris leaves (EOCS) the following tests were used: rat paw edema, granulomatous tissue test, vascular permeability, writhing test, gastric ulcer stress-induced & evaluation of gastric secretion (pylorus ligation test). With the overall results obtained in this study the authors suggest an anti-inflammatory activity for the EOCS of Casearia sylvestris beyond its anti-ulcer activity.

   • According to Sertie J A (2000)

     Excerpt Antiulcer activity of the crude extract from the leaves of Casearia sylvestris.

   • According to Ameni AZ (2015)

     Excerpt Casearia sylvestris S.w (Salicaceae) is catalogued by the Brazilian Unified Health System as a plant of interest for the Brazilian population with the purpose of treating inflammatory disorders, such as pain and gastrointestinal disorders based on the folk use and some literature about efficacy; however, no toxicological studies concerned the safety of extract fluid of this plant have been reported. sylvestris could be safe even when used over a long period for therapeutic uses proposed by the Brazilian Unified Health System.

   • According to De Matos E (2007)

     Excerpt The antinociceptive properties of Casearia sylvestris Sw. The antinociceptive effect of CS extract in the acetic acid test was prevented by prior treatment with the non-selective opioid receptor antagonist naloxone (1mg/kg; 5.8+/-4.2 & 31.5+/-3.1 writhes in vehicle-treated & naloxone-treated groups, respectively), indicating that the endogenous opioid system is involved in its analgesic mechanism of action.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.