Catharanthus roseus (kaka-poul) : medicinal properties in alcoholic extraction

Catharanthus roseus (kaka-poul, Pèvanch, Caca-poule, Pervenche) — family Apocynacées.

Scientific synonyms : Vinca rosea-L, Lochnea rosea-(L)-R ex. Endl..

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 20 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 105 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella oxytoca, K. pneumoniae, Proteus mirabilis, Salmonella Typhimurium, S. paratyphi

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Balaabirami S (2012)

     Excerpt The antimicrobial activity has been checked against microorganisms like Escherichia coli (MTCC - 443), Klebsiella oxytoca (MTCC - 4676), K pneumoniae (MTCC- 7162), Proteus mirabilis (ATCC -49565), Pseudomonas aeruginosa (MTCC -5210), S. Typhimurium (ATCC -13311), Salmonella paratyphi (MTCC‐735), Staphylococcus aureus (MTCC -740) & 2425), Aspergillus fumigatus (MTCC -9657), Candida albicans (MTCC- 183), Penicillium chrysogenum (MTCC- 160), Aspergillus flavus (AFG3) antifungal activity against Aspergillus niger (MTCC- by disc diffusion method.

   • According to GOVINDASAMY C (2012)

     Excerpt To identify the antibacterial activity and phytochemical analysis of Catharanthus roseus (C. coli), Staphylococcus aureus (S.

   • According to Roy S (2020)

     Excerpt However, agar well diffusion method was used for antimicrobial testing of organic extracts against multidrug resistant (MDR) foodborne Gram-positive (Staphylococcus hominis) a Gram-negative (Citrobacter freundii, Escherichia coli & Aeromonas caviae) bacteria. The present study focuses on the phytochemical analysis & antimicrobial properties of medicinally recognized known plant of Catharanthus roseus.

   • According to Kratika K (2013)

     Excerpt Assessment of antifungal activity of Catharanthus roseus was done by paper disc diffusion method. The present study aims to determine the antifungal activity of C roseus against various clinically significant fungal strains (Candida albicans, Aspergillus fumigatus, Aspergillus niger, Fusarium moniliforme).

   • According to Farnsworth NR (1968)

     Excerpt Farnsworth NR et al, Antiviral activity of selected Catharanthus alkaloids, Jl Pharmacol Sci.

2. 2

   Incision, injury, diabetic ulcer

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Vega-Ávila E (2012)

     Excerpt The aim of this study was to evaluate the hypoglycemic activity of extracts from the flower, leaf, stem, & root in normal & alloxan-induced diabetic mice. The blood glucose lowering activity of these extracts was determinate in healthy & alloxan-induced (75 mg/Kg) diabetic mice, after intraperitoneal administration (250 mg/Kg body weight).

   • According to Natarajan A (2012)

     Excerpt Effect of aqueous flower extract of Catharanthus roseus on alloxan induced diabetes in male Albino rats.

   • According to Al-Shaqha (2015)

     Excerpt roseus & an expression of GLUT-2 & GLUT-4 gene in streptozotocin induced diabetic Wistar rats. Conclusions: We conclude that the observed antidiabetic effect of CS on STZ induced diabetes was a result of complex mechanisms of GLUT gene mRNA expression.

   • According to Azam K (2022)

     Excerpt This study was designed to investigate anti-hyperlipidemic & anti-diabetic activity of ethanolic leaf extract of Catharanthus roseus alone & in combination therapy in hyperlipidemic & diabetic mice. Ethanolic extract of CR has significant anti-hyperlipidemic & anti-diabetic effects (p<0.05, p<0.01) when compared with control but had not cause significantly increase in anti-hyperlipidemic effects of atorvastatin.

   • According to Rasineni (2010)

     Excerpt Catharanthus roseus is a traditional medicinal plant used to control diabetes, in various regions of the world. In the diabetic-treated group lowering of plasma glucose & an increase in plasma insulin were observed after 15 days & by the end of the experimental period the plasma glucose had almost reached the normal level, but insulin had not.

3. 3

   Type II diabetes mellitus: synergistic combination with sitagliptin

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Al-Shaqha (2015)

     Excerpt roseus & an expression of GLUT-2 & GLUT-4 gene in streptozotocin induced diabetic Wistar rats. Conclusions: We conclude that the observed antidiabetic effect of CS on STZ induced diabetes was a result of complex mechanisms of GLUT gene mRNA expression.

   • According to Azam K (2022)

     Excerpt This study was designed to investigate anti-hyperlipidemic & anti-diabetic activity of ethanolic leaf extract of Catharanthus roseus alone & in combination therapy in hyperlipidemic & diabetic mice. Group F, G, H received sitagliptin (40 mg/kg), leaf extract (200 mg/kg) & extract in combination with sitagliptin (200 mg/kg & 40 mg/kg) orally for 7 days.

   • According to Rasineni (2010)

     Excerpt Catharanthus roseus is a traditional medicinal plant used to control diabetes, in various regions of the world. In the diabetic-treated group lowering of plasma glucose & an increase in plasma insulin were observed after 15 days & by the end of the experimental period the plasma glucose had almost reached the normal level, but insulin had not.

   • According to Vega-Ávila E (2012)

     Excerpt The aim of this study was to evaluate the hypoglycemic activity of extracts from the flower, leaf, stem, & root in normal & alloxan-induced diabetic mice. The blood glucose lowering activity of these extracts was determinate in healthy & alloxan-induced (75 mg/Kg) diabetic mice, after intraperitoneal administration (250 mg/Kg body weight).

   • According to Natarajan A (2012)

     Excerpt Effect of aqueous flower extract of Catharanthus roseus on alloxan induced diabetes in male Albino rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.