Ceiba pentandra (Fromajié) : medicinal properties in alcoholic extraction

Ceiba pentandra (Fromajié, Gran-Mapou, Fromager, Grand Mapou) — family Bombacacées.

Scientific synonyms : Bombax guineense-Thon, Eriodendron anfractusosum-DC, Gossampinus alba-Ham, Xylon pentandrum-(L)-Kurtz.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 19 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 64 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Manoharan S (2009)

     Excerpt Diabetes mellitus was induced with streptozotocin & graded doses of the ethanolic bark extract (200 & 400 mg/kg, b.w.) were then administered to the experimentally diabetic rats. Objective: To evaluate the hypoglycaemic & anti-hyperglycaemic effect of ethanolic extract of CP bark in normal & streptozotocin induced diabetic rats.

   • According to Kuete-Folié C (2018)

     Excerpt Parts of Ceiba pentandra are wildly used in Africa to treat diabetes and previous works have demonstrated their in vivo antidiabetic effects on type 1 diabetes models. But nothing is known about its effect on type II diabetes, especially on insulin resistance condition.

   • According to Dzeufiet DS (2007)

     Excerpt The aim of this work was to investigate the effect of daily oral administration of root bark methylene chloride/methanol extract of Ceiba pentandra (Linn) in streptozotocin-induced type-2 diabetic rats, & the effect of this treatment on the physiological & metabolic parameters that are related in diabetic animals. The results of this experimental animal study indicated that CP possesses antidiabetic activity; & thus, is capable of ameliorating hyperglycaemia in streptozotocin-induced type-2 diabetic rats & is a potential source for isolation of new orally active agent(s) for anti-diabetic therapy.

   • According to Satya P (2013)

     Excerpt OBJECTIVE: To evaluate the hypoglycaemic & antihyperglycaemic effect of ethanolic extract of Ceiba pentandra bark in normal and streptozotocin induced diabetic rats. Diabetes mellitus was induced with streptozotocin and graded doses of the ethanolic bark extract (200 and 400 mg/kg, b.w.) were then administered to the experimentally diabetic rats.

   • According to Wuyt AK (2023)

     Excerpt The antidiabetic effects of the methanol extract of the stem bark of Ceiba pentandra (Cp) have been demonstrated in various experimental models. Diseased animals were then orally treated with atorvastatin (80 mg/kg/d) or Cp (75 & 150 mg/kg/day) for 28 days during which food intake, body mass, blood pressure, heart rate, glucose, & insulin tolerance were monitored.

2. 2

   Diabetes mellitus: type I

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Manoharan S (2009)

     Excerpt Diabetes mellitus was induced with streptozotocin & graded doses of the ethanolic bark extract (200 & 400 mg/kg, b.w.) were then administered to the experimentally diabetic rats. Objective: To evaluate the hypoglycaemic & anti-hyperglycaemic effect of ethanolic extract of CP bark in normal & streptozotocin induced diabetic rats.

   • According to Kuete-Folié C (2018)

     Excerpt Parts of Ceiba pentandra are wildly used in Africa to treat diabetes and previous works have demonstrated their in vivo antidiabetic effects on type 1 diabetes models. But nothing is known about its effect on type II diabetes, especially on insulin resistance condition.

   • According to Dzeufiet DS (2007)

     Excerpt The aim of this work was to investigate the effect of daily oral administration of root bark methylene chloride/methanol extract of Ceiba pentandra (Linn) in streptozotocin-induced type-2 diabetic rats, & the effect of this treatment on the physiological & metabolic parameters that are related in diabetic animals. The results of this experimental animal study indicated that CP possesses antidiabetic activity; & thus, is capable of ameliorating hyperglycaemia in streptozotocin-induced type-2 diabetic rats & is a potential source for isolation of new orally active agent(s) for anti-diabetic therapy.

   • According to Satya P (2013)

     Excerpt OBJECTIVE: To evaluate the hypoglycaemic & antihyperglycaemic effect of ethanolic extract of Ceiba pentandra bark in normal and streptozotocin induced diabetic rats. Diabetes mellitus was induced with streptozotocin and graded doses of the ethanolic bark extract (200 and 400 mg/kg, b.w.) were then administered to the experimentally diabetic rats.

   • According to Wuyt AK (2023)

     Excerpt The antidiabetic effects of the methanol extract of the stem bark of Ceiba pentandra (Cp) have been demonstrated in various experimental models. Diseased animals were then orally treated with atorvastatin (80 mg/kg/d) or Cp (75 & 150 mg/kg/day) for 28 days during which food intake, body mass, blood pressure, heart rate, glucose, & insulin tolerance were monitored.

3. 3

   Bacterial infection: Escherichia coli, Staphylococcus aureus, S. epidermidis, Klebsiella pneumoniae, aerogenic Enterobacter species, Pseudomonas aeruginosa, Salmonella Typhimurium, S. typhi, Proteus vulgaris

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2017)

     Excerpt In the present study the aqueous, methanol, ethanol & acetone extract of Ceiba pentandra were screened for the presence of phytochemical components and tested for antibacterial activity against Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, Enterobacter aérogènes, Pseudomonas a aeruginosa, Salmonella Typhimurium, Salmonella typhi, Staphylococcus epidermidis & Proteus vulgaris. The acetone extracts had wide range of antibacterial activity against bacterial pathogens than the ethanol & methanol extract, whereas aqueous extract was slightly higher antibacterial activity as ethanol extract.

   • According to Chekuboyina RK (2012)

     Excerpt Oil extracted from Ceiba pentandra seed was studied to explore its suitability for ethnomedical uses with a special emphasis on its physiochemical characterization, antimicrobial behavior & Spectro-photometric parameters. Minimum inhibitory concentrations & minimum bactericidal & fungicidal concentrations of the seed oil varied between 3 to 10 mg/50 μL against all bacterial & fungal strains used in this study.

   • According to Alagawadi KR (2011)

     Excerpt Present study was carried out to evaluate the anti-inflammatory effects of petroleum ether & ethanolic extract of the seeds of Ceiba pentandra (L). The plant has been used as antibacterial, anti-inflammatory, antipyretic, for rheumatism, diabetes & in headache in Indian system of traditional medicine.

   • According to ALAGANDI KR (n.d.)

     Excerpt Ceiba pentandra commonly known as Silk cotton tree. The plant has been used as antibacterial, antiinflammatory, antipyretic, in Rheumatism, diabetes & in headache in Indian system of traditional medicine.

   • According to Author (2012)

     Excerpt The antibacterial activities of the ethanolic extract of leaf (ELE), stem bark (ESE) & their combination (CLSE) were evaluated in vitro using selected human pathogens such as Klebsiella pneumonia, Pseudomonas aeruginosa, Staphylococcus aureus & Escherichia coli. In conclusion, ethanolic extract of leaf and stem bark of C pentandra as well as their combination showed significant antibacterial activity.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.