Celtis iguanea : medicinal properties in alcoholic extraction

Celtis iguanea (Kwôk-chien, Grat-janmb, Croc-à-chien, gratte-jambe) — family Ulmacées.

Scientific synonyms : Celtis aculeata Sw., Momisia iguanaea (Jacq.) Rose & Standl, Rhamnus iguanaea Jacq., R iguanaeus Jacq..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 5 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 18 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Osteoarthritis, arthritis; rheumatism, oedema

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to De Moraes FW (2022)

     Excerpt The antinociceptive & anti-inflammatory activities of crude ethanolic extract of Celtis iguanaea leaves & their active fractions are reported. In conclusion, the DF showed antinociceptive activity that involves the vanilloid system as well as anti-inflammatory effect & the EAF showed anti-inflammatory activity involving the reduction of TNF-α cytokine.

   • According to RIBEIRO KR (2025)

     Excerpt This study evaluated the in vitro antioxidant capacity & the in vivo antinociceptive & anti-inflammatory mechanisms of the standardized spray-dried Celtis iguanaea hydroethanolic leaf extract (SDCi). These findings support SDCi as an effective anti-inflammatory & antinociceptive phytopharmaceutical intermediate, with potential applications in managing pain & inflammation,.

   • According to Almeida D.D.S (2024)

     Excerpt We demonstrated the antinociceptive & anti-inflammatory effects of the ethyl acetate leaf extract of Celtis iguanaea (Jacq.) Sargent (EEAc) in mice. The antinociceptive effect of EAECi is attributed to its anti-inflammatory activity, as evidenced by its anti-hyperalgesic & antiedematogenic effects.

   • According to SAMADD A (2024)

     Excerpt Their extracts & pure substances have been shown to have the same anticancer, antibacterial, anti-inflammatory, antioxidant, hepatoprotective, cardioprotective, urease-inhibiting, & antidiarrheal properties as their traditional uses. Information on the Celtis genus was obtained from internet sources such as Google Scholar, Web of Science, PubMed, ScienceDirect, & so on by using appropriate keywords, including ethnobotanical, pharmacological, pharmaceutical, bioactivity, phytochemistry, & botanical features of the Celtis genus.

   • According to Zanchet B (2019)

     Excerpt The leaves are popularly used as anti-inflammatory, in the treatment of body pain & urinary infections. The species Celtis iguanaea (Jacq.) Sarg., (Cannabaceae) is widely distributed in Brazil where it is known as “esporão-de-galo or taleira”.

2. 2

   Pain, hyperalgesia,

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to De Moraes FW (2022)

     Excerpt The antinociceptive & anti-inflammatory activities of crude ethanolic extract of Celtis iguanaea leaves & their active fractions are reported. The oral treatment with dichloromethane fraction (DF; 9 mg/Kg) produced antinociceptive effect in both phases of formalin test; however, the treatment with ethyl acetate fraction (EAF; 16 mg/Kg) reduced pain only in the second phase of this test.

   • According to RIBEIRO KR (2025)

     Excerpt This study evaluated the in vitro antioxidant capacity & the in vivo antinociceptive & anti-inflammatory mechanisms of the standardized spray-dried Celtis iguanaea hydroethanolic leaf extract (SDCi). These findings support SDCi as an effective anti-inflammatory & antinociceptive phytopharmaceutical intermediate, with potential applications in managing pain & inflammation,.

   • According to Leite da Veiga M (2016)

     Excerpt Celtis iguanaea is popularly known as “Esporão-de-galo” in Portuguese and its leaves are traditionally used in infusion forms as analgesic, antiasthmatic, digestive & diuretic. The aim of this study was to assess the acute & sub-acute toxicity of the crude extract from the Celtis iguanaea leaves in male rats.

   • According to Almeida D.D.S (2024)

     Excerpt We demonstrated the antinociceptive & anti-inflammatory effects of the ethyl acetate leaf extract of Celtis iguanaea (Jacq.) Sargent (EEAc) in mice. The antinociceptive effect of EAECi is attributed to its anti-inflammatory activity, as evidenced by its anti-hyperalgesic & antiedematogenic effects.

   • According to Rodrigues-Martin JL (2014)

     Excerpt The hydroxyl-linolenic acid, linoleic acids & conjugated oxo-linoleic acids are among the phytoconstituents that were identified in the Celtis iguanaea HE,. Celtis iguanaea (Canabaceae) is popularly known as esporão-de-galo, stands out among the medicinal plants used for treatment of gastric ulcers.

3. 3

   Dyslipidaemia: hypercholesterolaemia, hyperlipidaemia, hypertriglyceridaemia

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to ZANCHET B (2018)

     Excerpt Celtis iguanea is popularly used in the treatment of diabetes mellitus. Therefore, hypercholesterolemic rats (1% cholesterol) were orally treated with CI extract (C-150, CI-300, or CI-600 mg/kg) or Simvastatin (4 mg/kg) (n = 6) once a day (30 days) with a hypercholesterolemic diet.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.