Chamaesyce hirta (Malonmen) : medicinal properties in alcoholic extraction

Chamaesyce hirta (Malonmen, Misnamed, Mal-nommée) — family Euphorbiacées.

Scientific synonyms : Euphorbia hirta-L, Euphorbia pilulifera-L.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 30 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 85 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Normalisation of serum parameters (SGPT, SGOT, ALP, bilirubin), particularly following anti-tuberculosis chemotherapy

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to DUBEY S (2014)

     Excerpt Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, Bilirubin, were tested in both treated and untreated groups. Carbon tétra chloride (2 ml/kg) has enhanced the SGPT, SGOT, ALP, Bilirubin.

   • According to SENNIAPPAN P (2024)

     Excerpt Objective: The study aimed to determine the antiulcer and hepatoprotective activities of Euphorbia hirta petroleum ether, chloroform and ethanolic extracts on paracetamol-induced ulcerated Wistar rats. A significant (p < 0.001) reduction in SGPT, SGOT, ALP, DB & TB levels in the EEEH 400 mg/kg extract-treated group was observed compared to the paracetamol group.

   • According to OGEYEMHE BE (2026)

     Excerpt The results showed no statistically significant differences (p > 0.05) in serum liver enzyme activities or bilirubin concentrations between treated groups & the control. Serum activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, & bilirubin levels were determined using standard biochemical methods.

   • According to Apostol JG (2012)

     Excerpt hirta decoction prepared by boiling the fresh entire plant in distilled water for 15 minutes was lyophilized and the resulting solid was dissolved in distilled water & used to determine total phenolics and to prepare stock solutions administered to thrombocytopenic rats. The antithrombocytopenic effect of the solution of the lyophilized decoction of Euphorbia hirta was investigated in Sprague-Dawley rats with subnormal platelet counts induced by ethanol.

   • According to Tuhin RH (2017)

     Excerpt Several pharmacological properties including antiseptic, anti-inflammatory, antidiabetic, antispasmodic, antibacterial, antiviral, antifungal, anticonvulsant, nootropic, antifertility and aphrodisiac properties have already been reported for this plant. hirta was subjected to determine the total phenolic content and total flavonoid content using galic acid and quercetin, respectively as standard.

2. 2

   Hepatitis, cirrhosis, fatty liver

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to DUBEY S (2014)

     Excerpt Ethanolic extract of Euphorbia hirta Linn was prepared and tested for its hepatoprotective effect against CCl4induced hepatitis in rats. Treatment with Ethanolic extract of Euphorbia hirta Linn (100 mg/kg and 300 mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.

   • According to SENNIAPPAN P (2024)

     Excerpt Objective: The study aimed to determine the antiulcer and hepatoprotective activities of Euphorbia hirta petroleum ether, chloroform and ethanolic extracts on paracetamol-induced ulcerated Wistar rats. The air-dried whole plant was crushed, & 500 g of the powder & petroleum ether, chloroform & ethanol were used for continuous extraction by the Soxhlet device.

   • According to Apostol JG (2012)

     Excerpt hirta decoction prepared by boiling the fresh entire plant in distilled water for 15 minutes was lyophilized and the resulting solid was dissolved in distilled water & used to determine total phenolics and to prepare stock solutions administered to thrombocytopenic rats. The antithrombocytopenic effect of the solution of the lyophilized decoction of Euphorbia hirta was investigated in Sprague-Dawley rats with subnormal platelet counts induced by ethanol.

   • According to OGEYEMHE BE (2026)

     Excerpt A subacute experimental study was conducted to evaluate the short-term hepatic effects of aqueous Euphorbia hirta extract in adult male albino rats. These findings indicate that short-term oral administration of aqueous EH extract at the tested doses does not induce biochemical or histopathological evidence of liver injury.

   • According to Tuhin RH (2017)

     Excerpt hirta was subjected to determine the total phenolic content and total flavonoid content using galic acid and quercetin, respectively as standard. hirta is famous for its medicinal importance among the tribal population.

3. 3

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Maurya AK (2012)

     Excerpt The present study was aimed to evaluate the antidiabetic activity potential of Euphorbia hirta leaves against streptozotocin (STZ) induced experimental rats. An ethanolic extract of E hirta was found to reduce blood sugar in streptozotocin induced diabetic rats.

   • According to Shwetha S (2023)

     Excerpt Conclusion: The results of the presents investigation recommends that, one of the mechanisms of ETOH extract of EH for antidiabetic activity is reduction of insulin resistance. The objective of current investigation was to assess the mechanism of action of Euphorbia hirta for its antidiabetic properties.

   • According to Tuhin RH (2017)

     Excerpt A single injection of alloxan monohydrate (120 mg/kg, i.p.) prepared in normal saline was administered to produce diabetes in rats, after overnight fasting. The aim of present work was to evaluate the wound healing property in diabetic animals by oral and topical administration of ethanolic extract of E.

   • According to Sharma A (2025)

     Excerpt Euphorbia hirta Linn is a widely recognized medicinal herb utilized in traditional medicine systems for treating respiratory ailments, gastrointestinal disorders, skin conditions, & wounds. Experimental studies have demonstrated a range of pharmacological effects, such as antimicrobial, anti-inflammatory, antioxidant, antidiabetic, anticancer, wound-healing properties.

   • According to Bachhhar V (2024)

     Excerpt Further antioxidant (DPPH & Phosphomolybdate assay) & antidiabetic activity were evaluated with the IC50 value of 39.01 ± 0.56, 48.29 ± 0.69, & 55 ± 1.69 µg/ml, respectively, which indicated the potency of the synthesized nanoparticles for various biomedical & pharmacological applications. In this study, titanium dioxide nanoparticles(TiO2 NPs) have been synthesized by ultrasonication-assisted cold maceration green technique mediated through stem extract of Euphorbia hirta such that the plant's phytochemical constituents are preserved & do not deteriorate.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.