Cinnamonum verum (Cinnamon) : medicinal properties in alcoholic extraction

Cinnamonum verum (Cinnamon, Kannèl, cannelle) — family Lauracées.

Scientific synonyms : Cinnamomum Zeylanicum-Breyne, C zeylanicum Blume, Laurus Cinnamomum-Linn.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 22 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 112 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ishaq BM (2022)

     Excerpt Group 1 acts as a normal control, Group 2 as a diabetic control, & Group 3 as a standard control, all animals of Group 3 were given Glibenclamide at a dose of 5 mg/kg p. Streptozotocin (60 mg/kg, i.p.) was used to induce diabetes.

   • According to Mishra A (2010)

     Excerpt The current study was designed to evaluate the ameliorative effect of the Cinnamon oil upon early-stage diabetic nephropathy owing to its antioxidant & antidiabetic effect. Early stage of diabetic nephropathy was induced by administration of alloxan (150 mg/kg, I.

   • According to Gulcin I (2019)

     Excerpt Ethanolic (EEC) & aqueous (WEC) extracts of Cinnamomum verum were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods. As a conclusion, both EEC & WEC had rich phenolic contents & demonstrated effective anticholinergic, antidiabetic & antioxidant effects.

   • According to Joshi K (2010)

     Excerpt Cinnamomum zeylanicum, a commonly used spice and well-known medicinal plant has been reported to have anti-diabetic, anti-oxidant & anti-microbial properties.

   • According to Verspohl E J (2005)

     Excerpt Rats were given Cinnamomum cassia bark or extracts from Cinnamomum cassia & zeylanicum to evaluate blood glucose & plasma insulin levels in rats under various conditions. The elevation in plasma insulin was direct since a stimulatory in vitro effect of insulin release from INS-1 cells (an insulin secreting cell line) was observed.

2. 2

   Cancer: adjuvant treatment for carcinoma: Ayurvedic formulation: Kanchan GUGULLU

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Varadarajan S (2020)

     Excerpt Clinical significance: The anticancer properties of CV could be explored further for prevention & management of oral squamous cell carcinoma. Conclusion: CV its active compounds exhibited in vitro anticancer effects on oral squamous cell carcinoma.

   • According to Husain L (2018)

     Excerpt Conclusion: Ethanolic bark extract of CZ could be potentially beneficial in treating breast cancer & may be of interest for future studies in developing integrative cancer therapy against proliferation, metastasis, & migration of breast cancer cells. Aim of the study: In the present study, apoptotic & anti-microbial activity of ethanolic extract of CZ was evaluated against human breast cancer cell line MDA-MB-231 & compared for its effect on normal kidney epithelial cell line Vero.

   • According to KUBATKA P (2020)

     Excerpt Assessment of epigenetic changes in rat tumor cells in vivo showed a significant decrease in lysine methylation status of H3K4m3 & H3K9m3 in the high-dose treated group, a dose-dependent increase in H4K16ac levels (H4K20m3 was not changed), down-regulations of miR21 & miR155 in low-dose cinnamon groups (miR22 & miR34a were not modulated), & significant reduction of the methylation status of two out of five gene promoters ATM & TIMP3 (PITX2, RASSF1, PTEN promoters were not changed). Comprehensive oncology research suggests an important role of phytochemicals or whole plant foods in the modulation of signaling pathways associated with anticancer action.

   • According to Qabaha K (2017)

     Excerpt The objective of this work is to evaluate the in vitro inhibitory effect of C longa & Cinnamon ethanolic extracts on Lipopolysaccharide (LPS)-induced Interlukin-6 (IL-6) & Tumor Necrosis Factor-α (TNF-α) by polymorphonuclear Cells (PMNCs).

   • According to Usha M (2012)

     Excerpt The in vitro antibacterial activities of two spices cinnamon bark (Cinnamonum zeylanicum) and Ajowan fruits (Trachyspermum ammi) ethanol & acetone extracts has been evaluated against two-gram negative food spoilage bacteria Pseudomonas sp., Escherichia coli & two-gram positive bacteria Bacillus subtilis & Staphylococcus aureus. The results obtained in the present study suggest that the ethanol extract of Czeylanicum & T ammi revealed a significant scope to develop a novel broad spectrum of antibacterial herbal formulation & can be used for cooked food preservation,.

3. 3

   Pain, hyperalgesia

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Qabaha K (2017)

     Excerpt Curcuma longa & Cinnamon are used in folkloric medicine & thought to have different pharmacological activities including anti-inflammatory effects. The observed anti-inflammatory effect may be due to the presence of curcuminoids & cinnamic acid from C longa & Cinnamon, respectively.

   • According to Klinthong S (2015)

     Excerpt The crude ethanol extract in various concentrations (25, 50, 100 mg/kg) were tested for anti-inflammatory activity in cotton pellet-induced granuloma in rats. It was found that the extract of the RSDM formula at 50 mg/kg, per oral, showed significant inhibitory effect (p < 0.05) on granuloma formation comparable to indomethacin, a standard non-steroidal antiinflammatory drug (5 mg/kg).

   • According to Pandey M (2015)

     Excerpt In the present study, ethanol & aqueous extracts of leaf galls of Cinnamomum verum were prepared to evaluate the antioxidant activity using 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging assay and superoxide radical scavenging assay with ascorbic acid as a standard, and analgesic activity by tail immersion test & acetic acid-induced writhing test methods using diclofenac sodium as the reference drug. For analgesic activity, ethanol extract showed the maximum time required for response against thermal stimuli (6.75±0.47 s) & maximum % of writhing inhibition (44.57%) when compared to aqueous extract (5.25±0.48 s & 32.61%), whereas diclofenac showed response in 7.25±0.25 s 67.39% inhibition in tail immersion & writhing tests, respectively.

   • According to Khan MS (2011)

     Excerpt This study was aimed to evaluate effects of certain essential oils namely Cinnamomum verum, Syzygium aromaticum, Cymbopogon citratus, C martini & their major components cinnamaldehyde, eugenol, citral & geraniol respectively, on growth, hyphal ultrastructure & virulence factors of Aspergillus fumigatus & Trichophyton rubrum. Our findings highlight anti-elastase & anti-keratinase activity of above-mentioned essential oils as a novel property to be exploited in controlling invasive & superficial mycoses.

   • According to Alibi S (2020)

     Excerpt The antimicrobial, anti-biofilm, anti-quorum sensing, & anti-oxidant activities of four essential oils extracted from Cinnamomum verum, Origanum majorana, Thymus vulgaris, & Eugenia caryophyllata against Gram-positive & Gram-negative multidrug-resistant bacteria were evaluated in vitro. These EOs have a remarkable anti-biofilm & anti-quorum sensing activities against almost all the species studied.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.