Citrus maxima (Chadèk) : medicinal properties in alcoholic extraction

Citrus maxima (Chadèk, Pomelos) — family Rutacées.

Scientific synonyms : Aurantium decumana-(L.)-Mill, A maximum-Burm., Citrus costata-Raf., C grandis -(L.) Osbeck, C pompelnos-Risso, C sabon-Siebold ex Hayata, C yamabuki -Yu. Tanaka.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 26 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 144 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment: for liver and breast cancer

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Da Silva ES (2018)

     Excerpt As several varieties of citrus are known to possess antioxidant & cancer chemopreventive properties, the aim of the study was to evaluate in vitro if this CM possess these properties. Toranja ‘Burarama’, Citrus maxima (Burm.) Merr.

   • According to Feksa DL (2018)

     Excerpt Non-alcoholic fatty liver disease is a spectrum of liver changes, ranging from hepatic steatosis to hepatocellular carcinoma. The objective of this study was to evaluate the n vitro antioxidant potential of the CM leaves extract & on Wistar rats submitted to hepatic steatosis induction by fructose-associated hyperlipid diet (FHD).

   • According to Riaz M (2015)

     Excerpt Citrus maxima peel is rich in natural phenolic compounds & has a long use in the traditional medicine. In addition, lipid peroxidation products (MDA), nitric oxide, advanced protein oxidation products level (APOP), & catalase activities were also analyzed along with the histological profiling for the inflammatory cell infiltration, collagen, & iron deposition in liver.

   • According to Nakamura M (2019)

     Excerpt Citrus grandis Osbeck has been as a remedy for liver damage & hang over.

   • According to LIN CY (2022)

     Excerpt The aim of this study was to explore the lipid-lowering effects of nobiletin & the underlying molecular mechanisms in vitro in hepatic cells & in vivo in zebrafish models. Nobiletin significantly inhibited ANGPTL3 promoter activity & attenuated the transcription factor liver X receptor-α (LXRα)-mediated ANGPTL3 transcription.

2. 2

   Type II diabetes mellitus,

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Reshmi SK (2099)

     Excerpt The aim of this study was to identify the bioactive compound of Citrus maxima fruit that targets the enzymes responsible for hyperglycaemia. Further application, such as developing food formulations from CM will benefit diabetic populations.

   • According to Ahmad AA. (2018)

     Excerpt Citrus maxima belongs to the genus Citrus of the family Rutaceae, an important fruit with great benefits for humans in the world.

   • According to Mohammed SM (2021)

     Excerpt The ethanol extract of Citrus maxima fruit peel was evaluated for its hypoglycaemic and hypolipidemic activity in normal and Streptozotocin (STZ)-induced diabetic rats, using fasting & glucose tolerance test measurements. Results showed that CM extract possesses significant antidiabetic activity against streptozotocin induced diabetic rats by decreasing blood glucose levels, maintaining body weight, & serum lipid concentrations to approximate normal level.

   • According to Abdul Muneer MT (2014)

     Excerpt citrus maxima have been recommended in traditional herbal medicine as the source of diabetic medication or remedy for diabetes. In view of the various effects of CM, this study was designed to assess the effect of CM stem bark on alloxan induced streptozotocin-induced type – II diabetic rats & glucose tolerance test,.

   • According to Mangesh, K (2014)

     Excerpt Animals will be randomly divided into 5 groups of 6 each & assigned as Group 1: Normal control (normal saline), Group 2: Diabetic control (Streptozotocin 65 mg/Kg), Group 3: Diabetic Citrus maxima (200 mg/Kg), Group 4: Diabetic Anvillea garcinii (300 mg/Kg), Group 5: Diabetic Glibenclamide (500 mcg/Kg). This study was designed to assess the effect of ethanolic extract of fruit peels of Citrus maxima & ethanolic extract of dried whole plant of Anvillea garcinii on streptozotocin-induced diabetic rats & glucose tolerance test.

3. 3

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Reshmi SK (2099)

     Excerpt The aim of this study was to identify the bioactive compound of Citrus maxima fruit that targets the enzymes responsible for hyperglycaemia. Further application, such as developing food formulations from CM will benefit diabetic populations.

   • According to Ahmad AA. (2018)

     Excerpt Citrus maxima belongs to the genus Citrus of the family Rutaceae, an important fruit with great benefits for humans in the world.

   • According to Mohammed SM (2021)

     Excerpt The ethanol extract of Citrus maxima fruit peel was evaluated for its hypoglycaemic and hypolipidemic activity in normal and Streptozotocin (STZ)-induced diabetic rats, using fasting & glucose tolerance test measurements. Results showed that CM extract possesses significant antidiabetic activity against streptozotocin induced diabetic rats by decreasing blood glucose levels, maintaining body weight, & serum lipid concentrations to approximate normal level.

   • According to Abdul Muneer MT (2014)

     Excerpt citrus maxima have been recommended in traditional herbal medicine as the source of diabetic medication or remedy for diabetes. In view of the various effects of CM, this study was designed to assess the effect of CM stem bark on alloxan induced streptozotocin-induced type – II diabetic rats & glucose tolerance test,.

   • According to Mangesh, K (2014)

     Excerpt Animals will be randomly divided into 5 groups of 6 each & assigned as Group 1: Normal control (normal saline), Group 2: Diabetic control (Streptozotocin 65 mg/Kg), Group 3: Diabetic Citrus maxima (200 mg/Kg), Group 4: Diabetic Anvillea garcinii (300 mg/Kg), Group 5: Diabetic Glibenclamide (500 mcg/Kg). This study was designed to assess the effect of ethanolic extract of fruit peels of Citrus maxima & ethanolic extract of dried whole plant of Anvillea garcinii on streptozotocin-induced diabetic rats & glucose tolerance test.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.