Citrus medica (Buddha's Hand) : medicinal properties in alcoholic extraction

Citrus medica (Buddha's Hand, Main de Bouddha) — family Rutacées.

Scientific synonyms : Citrus fragrans Salisb, C Medica var sarcodactylis- (Hoola Van Nooten) -Swingle, C sarcodactylis-VH.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 137 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Peng CH (2009)

     Excerpt In conclusion, FC fruits that concomitantly possess insulin secretagogue & slimming effects would be very beneficial to type 2 diabetes mellitus patient. By kinetic analysis on the hypoglycemic patterns of the intraperitoneal glucose tolerance (IPGTT) & the insulin-glucose tolerance tests (IGTT), its insulin secretagogue effect was confirmed.

   • According to Hetta M (2013)

     Excerpt From 70% aqueous methanol extract of the defatted powdered leaves of Citrus medica L. The antihyperglycemic activity exerted a significant reduction in blood glucose level to (105.2±8.35) in diabetic rats after one month of treatment with a dose of 200 mg/kg & to (87.4±6.30) with 400mg, when compared to Gliclazide standard (110.8±7.24) (P< 0.05).

   • According to Menichini F (2016)

     Excerpt This study aimed to investigate the antidiabetic, antilipidaemic & antioxidant activities of Citrus medica cv Diamante (Rutaceae) hydroalcoholic (CD) peel extract in Zucker diabetic fatty (ZDF) rats.

   • According to Menichini F (2011)

     Excerpt This study evaluated the in vitro inhibition of carbohydrate-hydrolysing enzymes, the stimulation of insulin secretion, and the in vivo metabolic effects in mice of Citrus medica L. Measurements of the effects of peel extract on the mouse insulinoma MIN6 β-cells indicated that it did exert direct stimulatory effects on the exocytotic release of insulin in a concentration-dependent manner.

   • According to Sah AN (2011)

     Excerpt The objective of the present investigation was to evaluate the antidiabetic & hypolipidemic activity of petroleum ether extract of Citrus medica Linn. One group was selected as control group (buffer alone) and four groups of STZ induced diabetic rats (n = 5 in each group) were administered vehicle (1% tween 80), seed extract (200 & 400 mg/kg, p.o.) of CM & standard drug Glibenclamide (5 mg/ kg) for 15 days after 10 days of single dose of STZ (60 mg/kg) intraperitoneal administration.

2. 2

   Cancer: adjuvant treatment for gastric adenocarcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Suchitra MR (2020)

     Excerpt the leaves of Citrus medica have been named traditionally do possess activities in the gastric mucosa. The ethanolic leaf extract of CM possessed antioxidant & anticancer properties in gastric mucosal lines.

   • According to Alaqeel NK (2023)

     Excerpt To explore the most effective uses of citrus peel-derived antioxidants, this review presents background information, an overview of the role of citrus antioxidants in cancer therapy, & a discussion of the key underlying molecular mechanisms. In particular, the antioxidant chemicals found in citrus peel have been identified as potential cancer-fighting agents.

   • According to Barreca D (2020)

     Excerpt The unique characteristics of their basic skeleton & the nature & position of the substituents have attracted & stimulated vigorous investigations as a consequence of an enormous biological potential, that manifests itself as (among other properties) antioxidant, anti-inflammatory, antiviral, antimicrobial, & anticancer activities. Apigenin, diosmetin, luteolin, acacetin, chrysoeriol, and their respective glycosides, that occur in concentrations up to 60 mg/L, are the most common flavones found in Citrus fruits & juices.

   • According to Liu B (2023)

     Excerpt In this study, we synthesized AuNPs using leaf extract of Citrus medica (C. Additionally, it was seen that biosynthesized AuNPs show selective inhibition on the proliferation of HepG2 (human liver cancer cell line) relative to THLE3 (normal adult liver epithelial cells) via generation of ROS & MDA, reduction of GSH level and SOD activity, & over expression of Bax/Bcl-2and Caspase-3 mRNA.

   • According to Tundis R (2023)

     Excerpt This review focused on the composition & biological properties of the EOs of C medica & C Clementina & their main constituents, limonene, γ-terpinene, myrcene, linalool, & sabinene. Citrus is an important genus in the Rutaceae family, with high medicinal & economic value, & includes important crops such as lemons, orange, grapefruits, limes, etc.

3. 3

   Bacterial infection: S. aureus, L. monocytogenes, E. coli, P. aeruginosa, P. carotovorum

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Fratianni F (2019)

     Excerpt Salò̀—cultivated in the Cosenza province, Southern Italy, & to evaluate their antioxidant & antibacterial activity, performed against Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, Staphylococcus aureus, & Pectobacterium carotovorum. The aim of this paper was to study the polyphenols of peel and pulp of three Citrus taxa—Citrus medica, Citrus bergamia, & Citrus medica cv.

   • According to Vitalini S (2022)

     Excerpt The antibacterial activity against Bacillus cereus & Escherichia coli was evaluated by microwell dilution method to determine MIC & MBC values. The present work aimed to chemically characterize & evaluate the antiradical power & biological effects of Citrus medica var.

   • According to Selvaraju N (2022)

     Excerpt This work reports on the synthesis of prominent members of the carbon family, carbon quantum dots (CQDs), from a natural carbon precursor, Citrus medica fruit, & their inhibiting property against P. Pseudomonas aeruginosa (P.

   • According to Aliberti L (2016)

     Excerpt The antimicrobial activity of the EOs was assayed against some bacterial strains: Bacillus cereus (DSM 4313), Bacillus cereus (DSM 4384), Staphylococcus aureus (DSM 25693), Pseudomonas aeruginosa (ATCC 50071), & Escherichia coli (DSM 8579). The antimicrobial activity registered confirm their traditional uses as food preserving agents & led us to hypothesize the possible use of these oils as antimicrobials.

   • According to Hasan MM (2022)

     Excerpt Therefore, experiments were carried out to test the antibacterial activity of methanolic extracts of peels from various locally available citrus fruits such as citron (Citrus medica), satkora (Citrus macroptera) & adajamir (Citrus assamensis) against Bacillus spp. Citrus fruits can be exploited as antibacterial & antioxidant ingredients in food & nutraceuticals,

   • Excerpt according to the findings of this study.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.